Effects of Stochastic Flood Disturbance on Adult Wood Turtles, Glyptemys insculpta, in Massachusetts

The homing ability of non-marine turtles has been studied in a variety of taxa, and many species appear to be capable of short-range homing on the scale of several hundred meters or a few kilometers following experimental displacement. However, the behavioral response of turtles following a naturally caused displacement has seldom been reported. In this paper, we describe the effect of displacement ranging from 1.4 to 16.8 km (average = 4.8 km) by severe floods in a stream system in Massachusetts. We radio-tracked 38 adult Wood Turtles (Glyptemys insculpta) at five separate sites in Franklin County, Massachusetts, for periods ranging from one to four activity seasons and documented the displacement of a total of 12 Wood Turtles during seven floods between 2004 and 2008. Based on the average rate of displacement per flood and annual flood frequency, we estimate that, during our study, floods displaced over 40% of this Wood Turtle subpopulation annually. We present evidence that displacement results in elevated mortality rates and that displaced Wood Turtles mate and nest in the year following displacement at rates well below average; on a longer time scale, however, displacement by flooding may be an important mechanism of population connectivity in some areas. We also present evidence that most Wood Turtles avoid stream segments with stream gradient steeper than 1%; this may in part reflect an adaptation to avoid severe floods. Regional models and empirical data from stream gages suggest that flood intensity may currently be on an increasing trend. Conversion of upland from forest and fields to impervious surfaces and hardening of upstream riverbanks may have exacerbated recent flooding and decreased the resiliency of the riparian system to increased precipitation

Development of a Smartphone Application to Enable Remote Monitoring in the Outpatient Management of Cirrhotic Ascites

Patients who develop hepatic decompensation with ascites have a poor prognosis and often experience other complications including spontaneous bacterial peritonitis, hepatic encephalopathy and variceal bleeding. We hypothesised that smartphone (SP)-enabled remote monitoring of patients with ascites may enable early detection of infection and acute decompensation, facilitate timely intervention and improve patient outcomes. Aim:  We aimed to design, develop and implement a remote monitoring system (RMS) for outpatients with cirrhotic ascites. Method: We undertook surveys with patients and hepatologists to quantify the demand for a RMS and identify issues regarding implementation. A smartphone and a web-based application were developed as a RMS. Patients used the RMS in a 6-week prospective non-randomised trial.  Results: We surveyed 27 patients (mean age 56 years, 18 (67%) were male, 16 (59%) had Childs Pugh B cirrhosis, and 20 (74%) had a history of alcoholic liver disease) and 5 hepatologists. There were 19 patients (70%) who reported that they would use a RMS. The RMS was used by 10 patients for a mean 53.8days (11-70), who entered 20.6 (0-71) updates. A total of 18 automated alerts occurred. 22% of automated alerts resulted in clinically significant changes to management, such as inpatient admission n=1 (6%), early outpatient appointment n=1 (6%) and reinforced adherence n=2 (11%). Conclusion:   We have successfully designed an internet-enabled RMS for outpatients with cirrhotic ascites that could be used as an adjunct to existing outpatient services. Future studies will optimise the alert thresholds, assess long-term patient adoption and quantify clinical impact

Prospectus, January 15, 1971

STUDENT SENATE TO PICK ORANGIZATION OF THE YEAR; Speakers, Films, Panel To Highlight Teach-In Titled About Drugs ; Editors Of Student Newspapers See Censorship As Growing Threat; Problems Of Our Times: Emotion As A Cause; Guest Column; Letters;Bull Page: Ice Skating Party, SWAMP, Wit N\u27 Wisdom, Family Night, Decals, Drug Program, IOC, Student Transfers, Financial Aids, SIU Guest Day, Used Book Store, College Play, Debates Team, Yearbook, Flash Gordon, Vets Meeting, Student Government, Attention All Clubs; Parkland Holds Music Building Workshops; Chemistry Teacher Is Ex-Hockey Plater; Picture Schedule; Illini Freshman Defeat Cobras; I\u27m For Real: Apathy Strikes Cobras; Indoor Track; Danville Over PC; Sport Briefs; Athlete Of The Monthhttps://spark.parkland.edu/prospectus_1971/1016/thumbnail.jp

Система управления рисками в таможенных органах Канады

Объектом исследования является формирование политики СУР в таможенном деле Канады. Канады имеет развитую экономику, что доказывает её высокие позиции в мировых рейтингах. Целью работы является описание взаимосвязи внешнеэкономической деятельности Канады и организации системы управления рисками в таможенных органах Канады. Для достижения данной цели был проведён анализ внешнеэкономической деятельности Канады путём изучения бюджета страны, статистических данных и внешнеторговых договоров; изучение документации, которая описывает систему управления рисками таможенных органов КанадыThe object of the study is the formation of the policy of RMS in the customs of Canada. Canada has a developed economy, which proves its high position in the world rankings. The purpose of the work is to describe the relationship of foreign economic activity of Canada and the organization of risk management system in the Canadian customs To achieve this goal, the analysis of foreign economic activity of Canada was carried out by studying the country's budget, statistics and foreign trade contracts; study of documentation that describes the risk management system of the customs authorities of Canad

How a thrombectomy service can reduce hospital deficit:a cost-effectiveness study

BACKGROUND: There is level 1 evidence for cerebral thrombectomy with thrombolysis in acute large vessel occlusion. Many hospitals are now contemplating setting up this life-saving service. For the hospital, however, the first treatment is associated with an initial high cost to cover the procedure. Whilst the health economic benefit of treating stroke is documented, this is the only study to date performing matched-pair, patient-level costing to determine treatment cost within the first hospital episode and up to 90 days post-event. METHODS: We conducted a retrospective coarsened exact matched-pair analysis of 50 acute stroke patients eligible for thrombectomy. RESULTS: Thrombectomy resulted in significantly more good outcomes (mRS 0–2) compared to matched controls (56% vs 8%, p = 0.001). More patients in the thrombectomy group could be discharged home (60% vs 28%), fewer were discharged to nursing homes (4% vs 16%), residential homes (0% vs 12%) or rehabilitation centres (8% vs 20%). Thrombectomy patients had fewer serious adverse events (n = 30 vs 86) and were, on average, discharged 36 days earlier. They required significantly fewer physiotherapy sessions (18.72 vs 46.49, p = 0.0009) resulting in a median reduction in total rehabilitation cost of £4982 (p = 0.0002) per patient. The total cost of additional investigations was £227 lower (p = 0.0369). Overall, the median cost without thrombectomy was £39,664 per case vs £22,444, resulting in median savings of £17,221 (p = 0.0489). CONCLUSIONS: Mechanical thrombectomy improved patient outcome, reduced length of hospitalisation and, even without procedural reimbursement, significantly reduced cost to the thrombectomy providing hospital

Large-scale collaboration reveals landscape-level effects of land-use on turtle demography

Freshwater turtles and tortoises are declining worldwide and currently represent one of the most imperiled major vertebrate groups. Identifying the conditions that promote long-term viable populations is a critical conservation need. However, for most species, there is relatively little or no empirical information about the factors influencing population demographics. Large-scale population monitoring efforts necessary to acquire such information remain rare due to the logistic challenges associated with low and variable detectability, which generally preclude large monitoring initiatives by any single entity. The development of collaborative population monitoring programs represents one potential strategy for overcoming these challenges. Our goal was to leverage partnerships to identify the potential factors and relevant scales affecting wood turtle (Glyptemys insculpta) population demographics. Through a large-scale collaborative multi-institutional monitoring effort, we conducted 983 spring stream surveys at 293 sites across the northeastern United States. Wood turtle abundance was negatively associated with agriculture (300 m and 5500 m) and road traffic (5500 m) and positively associated with mature forest (5500 m). Juvenile proportion displayed strong negative relationships with stream gradient and imperviousness (300 m). Sex ratios were more male-skewed with higher mature forest cover (90 m) and road density (5500 m) and less undeveloped land (300 m). These findings suggest that effective conservation of demographically robust turtle populations will require consideration of multiple spatial scales. Landscape-level conservation may be particularly important for ensuring long-term viable populations. This study highlights the valuable role that collaboration across institutions and jurisdictions can play in the conservation of cryptic taxa

Progression from new methicillin-resistant Staphylococcus aureus colonisation to infection: An observational study in a hospital cohort

10.1186/1471-2334-13-491BMC Infectious Diseases131-BIDM

Measurement of Myofilament-Localised Calcium Dynamics in Adult Cardiomyocytes and the Effect of Hypertrophic Cardiomyopathy Mutations

Rationale: Subcellular Ca2+ indicators have yet to be developed for the myofilament where disease mutation, or small molecules may alter contractility through myofilament Ca2+ sensitivity. Here we develop and characterise genetically encoded Ca2+ indicators restricted to the myofilament to directly visualise Ca2 changes in the sarcomere. Objective: To produce and validate myofilament restricted Ca2+ imaging probes in an adenoviral transduction adult cardiomyocyte model using drugs that alter myofilament function (MYK-461, omecamtiv mecarbil and levosimendan) or following co-transduction of two established hypertrophic cardiomyopathy (HCM) disease causing mutants (cTnT R92Q and cTnI R145G) that alter myofilament Ca2+ handling. Methods and Results: When expressed in adult ventricular cardiomyocytes RGECO-TnT/TnI sensors localise correctly to the sarcomere without contractile impairment. Both sensors report cyclical changes in fluorescence in paced cardiomyocytes with reduced Ca2+ on and increased Ca2+ off rates compared with unconjugated RGECO. RGECO-TnT/TnI revealed changes to localised Ca2+ handling conferred by MYK-461 and levosimendan, including an increase in Ca2+ binding rates with both levosimendan and MYK-461 not detected by an unrestricted protein sensor. Co-adenoviral transduction of RGECO-TnT/TnI with HCM causing thin filament mutants showed that the mutations increase myofilament [Ca2+] in systole, lengthen time to peak systolic [Ca2+], and delay [Ca2+] release. This contrasts with the effect of the same mutations on cytoplasmic Ca2+, when measured using unrestricted RGECO where changes to peak systolic Ca2+ are inconsistent between the two mutations. These data contrast with previous findings using chemical dyes that show no alteration of [Ca2+] transient amplitude or time to peak Ca2+. Conclusions: RGECO-TnT/TnI are functionally equivalent. They visualise Ca2+ within the myofilament and reveal unrecognised aspects of small molecule and disease associated mutations in living cells