Spacetime Variable Superstring Vacua

In a general superstring vacuum configuration, the `internal' space (sector) varies in spacetime. When this variation is non-trivial only in two space-like dimensions, the vacuum contains static cosmic strings with finite energy per unit length and which is, up to interactions with matter, an easily computed topological invariant. The total spacetime is smooth although the `internal' space is singular at the center of each cosmic string. In a similar analysis of the Wick-rotated Euclidean model, these cosmic strings acquire expected self-interactions. Also, a possibility emerges to define a global time in order to rotate back to the Lorentzian case.Comment: 24 pages, harvmac, HUPAPP-93/

Multiparty Politics in America (First Edition)

In the wake of Ross Perot, Ralph Nader, and other third party and independent candidates that ran in the 1996 election, this collection of original essays by leading political scientists and third party officials is must reading for individuals interested in American politics. Multiparty Politics in America examines the roles that third parties have played in U.S. elections past and present and their prospects for the future. It presents unique and detailed coverage of the Reform, Green, and Libertarian parties\u27 goals and campaign strategies; discusses the kinds of reforms that would help them become more viable; and advances the debate over whether the U.S. should have a two-party or multiparty system.https://ideaexchange.uakron.edu/multiparty_politics1/1000/thumbnail.jp

Serious Bacterial Infections Acquired During Treatment of Patients Given a Diagnosis of Chronic Lyme Disease - United States.

The term "chronic Lyme disease" is used by some health care providers as a diagnosis for various constitutional, musculoskeletal, and neuropsychiatric symptoms (1,2). Patients with a diagnosis of chronic Lyme disease have been provided a wide range of medications as treatment, including long courses of intravenous (IV) antibiotics (3,4). Studies have not shown that such treatments lead to substantial long-term improvement for patients, and they can be harmful (1,5). This report describes cases of septic shock, osteomyelitis, Clostridium difficile colitis, and paraspinal abscess resulting from treatments for chronic Lyme disease. Patients, clinicians, and public health practitioners should be aware that treatments for chronic Lyme disease can carry serious risks

Quasar Evolution and the Baldwin Effect in the Large Bright Quasar Survey

From a large homogeneous sample of optical/UV emission line measurements for 993 quasars from the Large Bright Quasar Survey (LBQS), we study correlations between emission line equivalent width and both restframe ultraviolet luminosity (i.e., the Baldwin Effect) and redshift. Our semi-automated spectral fitting accounts for absorption lines, fits blended iron emission, and provides upper limits to weak emission lines. Use of a single large, well-defined sample and consistent emission line measurements allows us to sensitively detect many correlations, most of which have been previously noted. A new finding is a significant Baldwin Effect in UV iron emission. Further analysis reveals that the primary correlation of iron emission strength is probably with redshift, implying an evolutionary rather than a luminosity effect. We show that for most emission lines with a significant Baldwin Effect, and for some without, evolution dominates over luminosity effects. This may reflect evolution in abundances, in cloud covering factors, or overall cloud conditions such as density and ionization. We find that in our sample, a putative correlation between Baldwin Effect slope and the ionization potential is not significant. Uniform measurements of other large quasar samples will extend the luminosity and redshift range of such spectral studies and provide even stronger tests of spectral evolution.Comment: 16 pages, Latex, emulateapj style, including 3 tables and 6 figures. Accepted April 02, 2001 for publication in ApJ Main Journal. See also http://hea-www.harvard.edu/~pgreen/Papers.htm

In an in vitro model of human tuberculosis, monocyte-microglial networks regulate matrix metalloproteinase-1 and -3 gene expression and secretion via a p38 mitogen activated protein kinase-dependent pathway.

BACKGROUND: Tuberculosis (TB) of the central nervous system (CNS) is characterized by extensive tissue inflammation, driven by molecules that cleave extracellular matrix such as matrix metalloproteinase (MMP)-1 and MMP-3. However, relatively little is known about the regulation of these MMPs in the CNS. METHODS: Using a cellular model of CNS TB, we stimulated a human microglial cell line (CHME3) with conditioned medium from Mycobacterium tuberculosis-infected primary human monocytes (CoMTb). MMP-1 and MMP-3 secretion was detected using ELISAs confirmed with casein zymography or western blotting. Key results of a phospho-array profile that detects a wide range of kinase activity were confirmed with phospho-Western blotting. Chemical inhibition (SB203580) of microglial cells allowed investigation of expression and secretion of MMP-1 and MMP-3. Finally we used promoter reporter assays employing full length and MMP-3 promoter deletion constructs. Student's t-test was used for comparison of continuous variables and multiple intervention experiments were compared by one-way ANOVA with Tukey's correction for multiple pairwise comparisons. RESULTS: CoMTb up-regulated microglial MMP-1 and MMP-3 secretion in a dose- and time-dependent manner. The phospho-array profiling showed that the major increase in kinase activity due to CoMTb stimulation was in p38 mitogen activated protein kinase (MAPK), principally the α and γ subunits. p38 phosphorylation was detected at 15 minutes, with a second peak of activity at 120 minutes. High basal extracellular signal-regulated kinase activity was further increased by CoMTb. Secretion and expression of MMP-1 and MMP-3 were both p38 dependent. CoMTb stimulation of full length and MMP-3 promoter deletion constructs demonstrated up-regulation of activity in the wild type but a suppression site between -2183 and -1612 bp. CONCLUSIONS: Monocyte-microglial network-dependent MMP-1 and MMP-3 gene expression and secretion are dependent upon p38 MAPK in tuberculosis. p38 is therefore a potential target for adjuvant therapy in CNS TB

Gauge-Dependent Cosmological "Constant"

When the cosmological constant of spacetime is derived from the 5D induced-matter theory of gravity, we show that a simple gauge transformation changes it to a variable measure of the vacuum which is infinite at the big bang and decays to an astrophysically-acceptable value at late epochs. We outline implications of this for cosmology and galaxy formation.Comment: 14 pages, no figures, expanded version to be published in Class. Quantum Gra

Discovery of a z=4.93, X-ray selected quasar by the Chandra Multiwavelength Project (ChamP)

We present X-ray and optical observations of CXOMP J213945.0-234655, a high redshift (z=4.93) quasar discovered through the Chandra Multiwavelength Project (ChaMP). This object is the most distant X-ray selected quasar published, with an X-ray luminosity of L(X)=5.9x10^44 erg/s (measured in the 0.3-2.5 keV band and corrected for Galactic absorption). CXOMP J213945.0-234655 is a g' dropout object (>26.2), with r'=22.87 and i'=21.36. The rest-frame X-ray to optical flux ratio is similar to quasars at lower redshifts and slightly X-ray bright relative to z>4 optically-selected quasars observed with Chandra. The ChaMP is beginning to acquire significant numbers of high redshift quasars to investigate the unobscured X-ray luminosity function out to z~5.Comment: Published in ApJ Letters; 4 pages; 3 figures; http://hea-www.harvard.edu/CHAMP