Analysis of Micro-Financing on Youth Empowerment: Case of Micro-Finance Institutions in Murang’a County, Kenya

Over the past several decades, youth population in Murang’a County has been faced by grave mass unemployment challenge characterized by limited participation; colossal drugs, alcohol and substance abuse; severe crime and deviant behaviour; health related problems; limited and/or poor housing among others. While the number of youth serving organizations in the area has increased over the years, this problem continues to deteriorate. Various past studies have investigated impacts of massive youth unemployment. However, few studies have investigated effective ways of empowering the youth. Therefore, this survey study aims to find out an all-inclusive, practical and sustainable way of empowering youth population in Murang’a County through micro-financing. The study focus is development and implementation of a model of sustainable micro-entrepreneurship enabled by “social-conscious-driven” micro-financing without bearing detrimental externalities on the beneficiaries or the environment. The study objective is to analyze the four fundamental micro-financing facets: micro-credit, micro-entrepreneurship, micro-savings and entrepreneurial training on youth empowerment through participation, engagement and productivity in the economy. The study is significant as both the county and national government will be able to devise informed, effective and long term strategies of dealing with the massive youth unemployment. The researcher will also develop a need for further studies on effective youth empowerment programs in Kenya. The research design that was employed was descriptive research. The population of the study was 25% of youth population in Murang’a County that represents young micro-entrepreneurs. A sample size of 72 young micro-entrepreneurs was used. Single stage proportionate cluster sampling was used to select the 72 micro-entrepreneurs where each cluster represented a Sub-county in Murang’a County. Simple random sampling was thereafter used to select the required sample size. A series of self-administered questionnaires were distributed to the sampled micro-entrepreneurs. Descriptive data analysis was done using SPSS (Statistical Package for the Social Sciences) data analysis software version 17.0.  The data was presented in graphs, charts, tables and figures. Key Words: Micro- Financing Institutions, Youth Empowerment, Murang’a Count

Applying technology to promote sexual and reproductive health and prevent gender based violence for adolescents in low and middle-income countries: digital health strategies synthesis from an umbrella review

Aim: Adolescents in low-and-middle-income countries (LMICs) are facing numerous developmental, sexual and reproductive health (SRH) challenges including exposure to multidimensional violence. Gender-based violence (GBV) specifically intimate partner violence (IPV) are both highly prevalent in LMICs and are strongly linked with poor SRH outcomes. However, GBV and IPV interventions have not yet been adequately integrated in SRH due to individual, social, cultural, service, and resource barriers. To promote long-term SRH, a more holistic approach that integrates GBV and IPV, and adolescent development needs is imperative. Digital health has the potential to address multiple service setup, provision, and addressing access barriers through designing and providing integrated SRH care. However, there are no guidelines for an integrated digital SRH and development promotion for adolescents in LMICs. Methods: An umbrella review was conducted to synthesize evidence in three inter-related areas of digital health intervention literature: (i) SRH, (ii) GBV specifically IPV as a subset, and (iii) adolescent development and health promotion. We first synthesize findings for each area of research, then further analyze the implications and opportunities to inform approaches to develop an integrated intervention that can holistically address multiple SRH needs of adolescents in LMICs. Articles published in English, between 2010 and 2020, and from PubMed were included. Results: Seventeen review articles met our review inclusion criterion. Our primary finding is that application of digital health strategies for adolescent SRH promotion is highly feasible and acceptable. Although effectiveness evidence is insufficient to make strong recommendations for interventions and best practices suggestions, some user-centered design guidelines have been proposed for web-based health information and health application design for adolescent use. Additionally, several digital health strategies have also been identified that can be used to further develop integrated GBV-IPV-SRH-informed services to improve adolescent health outcomes. We generated several recommendations and strategies to guide future digital based SRH promotion research from our review. Conclusions: Rigorous research that focuses on intervention effectiveness testing using a combination of digital health strategies and standardized albeit contextualized outcome measures would be important. Methodological improvement such as adoption of longitudinal experimental design will be crucial in generating evidence-based intervention and practice guidelines for adolescents in LMICs. Keywords: Gender-based violence, Intimate partner violence, Sexual and reproductive health, Low-and-middle - income countries, mHealth, Digital health, Adolescents Development, Revie

Incorporation of dried goat rumen contents in layer diets improves egg yolk colour and acceptability of eggs

The use of dried goat rumen content (DGRC) as a partial replacement for fish meal in layer diets was investigated. A total of 90 H&N Brown Nick layer chickens were offered diets in which DGRC were incorporated at 0, 5 and 10% levels. Iso-caloric and nitrogenous diets were formulated to meet the recommended nutritional requirements for laying hens. Experimental birds were assigned to 9 cages (10 birds/cage) and experimental diets offered in a completely randomized design (CRD) with three replications. Data was collected on egg production and sensory characteristics of the eggs, and a partial budget analysis was undertaken. Diet significantly (P0.05). Eggs from layers offered 10% DGRC were more acceptable than those of layers fed on 0 and 5% diets. A significant effect (P<0.05) of treatments on yolk colour was observed. Eggs from 10% DGRC diets had more deep yellow yolks than eggs from 0 and 5% diets. It was concluded that use of DGRC in layer diets improved yolk colour, acceptability of the eggs and marginal rate of return (MRR)

Evaluation of chickpea genotypes for resistance to Ascochyta blight (Ascochyta rabiei) disease in the dry highlands of Kenya

Chickpea (Cicer arietinum) is an edible legume grown widely for its nutritious seed, which is rich in protein, minerals, vitamins and dietary fibre. It’s a new crop in Kenya whose potential has not been utilized fully due to abiotic and biotic stresses that limit its productivity. The crop is affected mainly by Ascochyta blight (AB) which is widespread in cool dry highlands causing up to 100% yield loss. The objective of this study was to evalu- ate the resistance of selected chickpea genotypes to AB in dry highlands of Kenya. The study was done in 2 sites (Egerton University-Njoro) and Agricultural Training centre-ATC-Koibatek) for one season during long rains of 2010/2011 growing season. Thirty six genotypes from reference sets and mini-core samples introduced from ICR- SAT were evaluated. There were significant (P&lt;0.001) differences in AB responses and grain yield performance in test genotypes in both sites. AB was more severe at Egerton-Njoro (mean score 5.7) than ATC-Koibatek (mean score 4.25), with subsequent low grain yield. Genotypes ICC7052, ICC4463, ICC4363, ICC2884, ICC7150, ICC15294 and ICC11627 had both highest grain yield in decreasing order (mean range 1790-1053 Kg ha-1) and best resist- ance to AB. Further evaluation is needed in other multi-locations and their use in breeding program determined especially because of their undesirable black seed color. Commercial varieties (LDT068, LDT065, Chania desi 1, and Saina K1) were all susceptible to AB, but with grain yield &gt;1200 Kg ha-1. The findings of the study showed that chickpea should be sown during the short rains (summer) in the dry highlands of Kenya when conditions are drier and warmer and less favorable for AB infection. However yield could be increased by shifting the sowing date from dry season to long rain (winter) thus avoiding terminal drought if AB resistant cultivars with acceptable agronomic traits could be identified

Phase II trial of standard versus increased transfusion volume in Ugandan children with acute severe anemia.

BACKGROUND: Severe anemia (SA, hemoglobin 6 g/dl: primary outcome) and 28-day survival. RESULTS: Median admission hemoglobin was 4.2 g/dl (IQR 3.1 to 4.9). Initial volume received followed the randomization strategy in 155 (97%) patients. By 24-hours, 70 (90%) children in the Tx30 arm had corrected SA compared to 61 (74%) in the Tx20 arm; cause-specific hazard ratio = 1.54 (95% confidence interval 1.09 to 2.18, P = 0.01). From admission to day 28 there was a greater hemoglobin increase from enrollment in Tx30 (global P <0.0001). Serious adverse events included one non-fatal allergic reaction and one death in the Tx30 arm. There were six deaths in the Tx20 arm (P = 0.12); three deaths were adjudicated as possibly related to transfusion, but none secondary to volume overload. CONCLUSION: A higher initial transfusion volume prescribed at hospital admission was safe and resulted in an accelerated hematological recovery in Ugandan children with SA. Future testing in a large, pragmatic clinical trial to establish the effect on short and longer-term survival is warranted. TRIAL REGISTRATION: ClinicalTrials.Gov identifier: NCT01461590 registered 26 October 2011

Smallholder cropping systems contribute limited greenhouse gas fluxes in upper Eastern Kenya

The contribution of smallholder farming systems to the National greenhouse gas (GHG) budget is missing in most developing countries, including Kenya. Data on the contribution of smallholder cropping systems to the GHG balance is essential for realising Sustainable Development Goal 13 on climate action, i.e., on nationally determined contributions (NDCs) and in compliance with the Paris Agreement. Do smallholder farming systems act as nature-based solutions for greenhouse gas emissions reduction? This study evaluated GHG emissions from cropping systems under on-farm smallholder farming conditions. We had five cropping systems on two smallholder farms: sole maize, maize-bean intercrop, coffee, banana, and agroforestry. Gas samples were collected using three static chambers per cropping system. The gas samples were analysed using gas chromatography (GC) fitted with a 63Ni-electron capture detector (ECD) for N2O and flame ionisation detector (FID) for CH4 and CO2 using N as carrier gas. Cumulative annual fluxes of (CH4, N2O, and CO2) varied significantly in farms one and two across the cropping systems. The cumulative soil GHG fluxes ranged from -1.34kg CH4single bondC ha−1 yr−1 under agroforestry to -0.77kg CH4single bondC ha−1 yr−1 under banana for CH4, 0.30kg N2Osingle bondN ha−1 yr−1 to 1.23kg N2Osingle bondN ha−1 yr−1 for N2O and 5949kg CO2single bondC ha−1 yr−1 to 12,954kg CO2single bondC ha−1 yr−1 for CO2. The maize grain yields ranged from 0 to 3.38 Mg ha−1. The N2O yields scaled emissions ranged from 0.10 to 0.26g kg−1 maize and 0.68 to 1.30g kg−1 beans. Smallholder farmers in Upper Eastern Kenya contribute a limited amount of soil GHG emissions and thus could act as a nature-based solution for lowering agricultural emissions

Assisted partner notification services to augment HIV testing and linkage to care in Kenya: study protocol for a cluster randomized trial

Background: HIV case-finding and linkage to care are critical for control of HIV transmission. In Kenya, >50% of seropositive individuals are unaware of their status. Assisted partner notification is a public health strategy that provides HIV testing to individuals with sexual exposure to HIV and are at risk of infection and disease. This parallel, cluster-randomized controlled trial will evaluate the effectiveness, cost-effectiveness, and feasibility of implementing HIV assisted partner notification services at HIV testing sites (clusters) in Kenya. Methods/design Eighteen sites were selected among health facilities in Kenya with well-established, high-volume HIV testing programs, to reflect diverse communities and health-care settings. Restricted randomization was used to balance site characteristics between study arms (n = 9 per arm). Sixty individuals testing HIV positive (‘index partners’) will be enrolled per site (inclusion criteria: ≥18 years, positive HIV test at a study site, willing to disclose sexual partners, and never enrolled for HIV care; exclusion criteria: pregnancy or high risk of intimate partner violence). Index partners provide names and contact information for all sexual partners in the past 3 years. At intervention sites, study staff immediately contact sexual partners to notify them of exposure, offer HIV testing, and link to care if HIV seropositive. At control sites, passive partner referral is performed according to national guidelines, and assisted partner notification is delayed by 6 weeks. Primary outcomes, assessed 6 weeks after index partner enrollment and analyzed at the cluster level, are the number of partners accepting HIV testing and number of HIV infections diagnosed and linked to care per index partner. Secondary outcomes are the incremental cost-effectiveness of partner notification and the costs of identifying >1 partner per index case. Participants are closely monitored for adverse outcomes, particularly intimate partner violence. The study is unblinded due to practical limitations. Discussion This rigorously designed trial will inform policy decisions regarding implementation of HIV partner notification services in Kenya, with possible application to other parts of sub-Saharan Africa. Examination of effectiveness and cost-effectiveness in diverse settings will enable targeted application and define best practices. Trial registration ClinicalTrials.gov NCT01616420

Brain Neuronal CB2 Cannabinoid Receptors in Drug Abuse and Depression: From Mice to Human Subjects

BACKGROUND: Addiction and major depression are mental health problems associated with stressful events in life with high relapse and reoccurrence even after treatment. Many laboratories were not able to detect the presence of cannabinoid CB2 receptors (CB2-Rs) in healthy brains, but there has been demonstration of CB2-R expression in rat microglial cells and other brain associated cells during inflammation. Therefore, neuronal expression of CB2-Rs had been ambiguous and controversial and its role in depression and substance abuse is unknown. METHODOLOGY/PRINCIPAL FINDINGS: In this study we tested the hypothesis that genetic variants of CB2 gene might be associated with depression in a human population and that alteration in CB2 gene expression may be involved in the effects of abused substances including opiates, cocaine and ethanol in rodents. Here we demonstrate that a high incidence of (Q63R) but not (H316Y) polymorphism in the CB2 gene was found in Japanese depressed subjects. CB2-Rs and their gene transcripts are expressed in the brains of naïve mice and are modulated following exposure to stressors and administration of abused drugs. Mice that developed alcohol preference had reduced CB2 gene expression and chronic treatment with JWH015 a putative CB2-R agonist, enhanced alcohol consumption in stressed but not in control mice. The direct intracerebroventricular microinjection of CB2 anti-sense oligonucleotide into the mouse brain reduced mouse aversions in the plus-maze test, indicating the functional presence of CB2-Rs in the brain that modifies behavior. We report for the using electron microscopy the sub cellular localization of CB2-Rs that are mainly on post-synaptic elements in rodent brain. CONCLUSIONS/SIGNIFICANCE: Our data demonstrate the functional expression of CB2-Rs in brain that may provide novel targets for the effects of cannabinoids in depression and substance abuse disorders beyond neuro-immunocannabinoid activity

Comparative Genomic Analysis of six Glossina Genomes, Vectors of African Trypanosomes

Background: Tsetse flies (Glossina sp.) are the vectors of human and animal trypanosomiasis throughout subSaharan Africa. Tsetse flies are distinguished from other Diptera by unique adaptations, including lactation and the birthing of live young (obligate viviparity), a vertebrate blood-specific diet by both sexes, and obligate bacterial symbiosis. This work describes the comparative analysis of six Glossina genomes representing three sub-genera: Morsitans (G. morsitans morsitans, G. pallidipes, G. austeni), Palpalis (G. palpalis, G. fuscipes), and Fusca (G. brevipalpis) which represent different habitats, host preferences, and vectorial capacity. Results: Genomic analyses validate established evolutionary relationships and sub-genera. Syntenic analysis of Glossina relative to Drosophila melanogaster shows reduced structural conservation across the sex-linked X chromosome. Sex-linked scaffolds show increased rates of female-specific gene expression and lower evolutionary rates relative to autosome associated genes. Tsetse-specific genes are enriched in protease, odorant-binding, and helicase activities. Lactation-associated genes are conserved across all Glossina species while male seminal proteins are rapidly evolving. Olfactory and gustatory genes are reduced across the genus relative to other insects. Visionassociated Rhodopsin genes show conservation of motion detection/tracking functions and variance in the Rhodopsin detecting colors in the blue wavelength ranges. Conclusions: Expanded genomic discoveries reveal the genetics underlying Glossina biology and provide a rich body of knowledge for basic science and disease control. They also provide insight into the evolutionary biology underlying novel adaptations and are relevant to applied aspects of vector control such as trap design and discovery of novel pest and disease control strategies