8 research outputs found
Crowdsourced mapping of unexplored target space of kinase inhibitors
- Author
- Aittokallio Tero
- Alexopoulos Leonidas
- Allaway Robert J.
- Atalay Mehmet Volkan
- ATALAY RENGĂL
- Atas Heval
- Bachmann Ivo
- Barel Gal
- Ben Guebila Marouen
- Boeckaerts Dimitri
- Briers Yves
- Capuzzi Stephen
- Chang Buru
- Chen Jhih-Yu
- Chen Tsai-Min
- Cichonska Anna
- Dang Kristen
- De Baets Bernard
- DOÄAN TUNCA
- Drewry David H.
- Fang Wei-Quan
- Fotis Christos
- Ganzlin Julia
- Guinney Justin
- Herwig Ralf
- Hu Hailin
- Huang Chih-Han
- Hunyady Laszlo
- Hwang Ming-Jing
- Isayev Olexandr
- Jeon Minji
- Kanev Georgi K.
- Kang Jaewoo
- Karimi Mostafa
- Kim Bumsoo
- Kim Sunkyu
- Kooistra Albert J.
- Koytiger Gregory
- Lamb Andrew
- Lee Junhyun
- Li Shuya
- Lienhard Matthias
- Lim Hansaim
- Lucic Bono
- Luo Yunan
- Martin Maria J.
- Mason Michael
- Misak Adam
- Nguyen Thin
- Ntagiantas Konstantinos
- Oprea Tudor I.
- Orsolic Davor
- Ozturk Hakime
- Park Sungjoon
- Peng Jian
- Popova Mariya
- Prasse Paul
- Ravikumar Balaguru
- RÄ°FAÄ°OÄLU AHMET SĂREYYA
- Schlessinger Avner
- Shamsaei Behrouz
- Shen Yang
- Shih Edward S. C.
- Singh Sourav
- Smuc Tomislav
- Stepanic Visnja
- Stock Michiel
- Stolovitzky Gustavo
- Szalai Bence
- TAN MEHMET
- Tanoli Ziaurrehman
- Terzopoulos Panagiotis
- Turu Gabor
- Wan Fangping
- Wang Xiaokang
- Wang Zhangyang
- Wells Carrow I.
- Wennerberg Krister
- Westerman Bart A.
- Willson Timothy M.
- Wu Chih-Hsun
- Wu Di
- Xie Lei
- Yun Seongjun
- Zeng Jianyang
- ĂZGĂR TĂRKMEN ARZUCAN
- ĂZKIRIMLI ĂLMEZ ELÄ°F
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/06/2021
- Field of study
Despite decades of intensive search for compounds that modulate the activity of particular protein targets, a large proportion of the human kinome remains as yet undrugged. Effective approaches are therefore required to map the massive space of unexplored compound-kinase interactions for novel and potent activities. Here, we carry out a crowdsourced benchmarking of predictive algorithms for kinase inhibitor potencies across multiple kinase families tested on unpublished bioactivity data. We find the top-performing predictions are based on various models, including kernel learning, gradient boosting and deep learning, and their ensemble leads to a predictive accuracy exceeding that of single-dose kinase activity assays. We design experiments based on the model predictions and identify unexpected activities even for under-studied kinases, thereby accelerating experimental mapping efforts. The open-source prediction algorithms together with the bioactivities between 95 compounds and 295 kinases provide a resource for benchmarking prediction algorithms and for extending the druggable kinome. The IDG-DREAM Challenge carried out crowdsourced benchmarking of predictive algorithms for kinase inhibitor activities on unpublished data. This study provides a resource to compare emerging algorithms and prioritize new kinase activities to accelerate drug discovery and repurposing efforts
Congenital Malformations of the Skull and Meninges
- Author
- Publication venue
- 'Elsevier BV'
- Publication date
- Field of study
Management and long-term follow-up review of children with lipomyelomeningocele, 1952â1987
- Author
- Publication venue
- 'Journal of Neurosurgery Publishing Group (JNSPG)'
- Publication date
- Field of study
: , (Behavioural Economics: Development, Condition and Perspectives)
- Author
- &
- A Tversky
- B Piniewski
- C Camerer
- C Camerer
- C Camerer
- C Sunstein
- C Sunstein
- D Kahneman
- D Kahneman
- Dimitar Kanev
- E Mccaffery
- F Furedi
- G Saint-Paul
- I Mcauley
- J Gowdy
- J Gruber
- J Gruber
- J Tomer
- L Bovens
- M Grunwald
- M Rizzo
- M White
- O Oullier
- October
- P Basham
- P Hansen
- R Prentice
- R Thaler
- S Easton
- S Mullainathan
- S Mullainathan
- T Leonard
- Venelin Terziev
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2017
- Field of study
Growth hormone deficiency following radiation therapy of primary brain tumors in children
- Author
- Publication venue
- 'Journal of Neurosurgery Publishing Group (JNSPG)'
- Publication date
- Field of study
The risks of metastases from shunting in children with primary central nervous system tumors
- Author
- Abbott KH
- Brander WL
- Brenda Baumeister
- Brust JCM
- Brutschin P
- Galassi E
- Gyepes MT
- J. Russell Geyer
- Jackson AM
- Jerry Milstein
- Kessler LA
- Kimura N
- Lowery GS
- Makeever LC
- McComb JG
- Mitchel S. Berger
- Morley TP
- Mosca L
- Oberbauer RW
- Oberman HA
- Paterson E
- Paul M. Kanev
- Perry RE
- Peter D. LeRoux
- Sadik AR
- Sakata K
- Schnitzler ER
- Triolo PJ
- Ushio Y
- Wilson ER
- Wolf A
- Wood BP
- Publication venue
- 'Journal of Neurosurgery Publishing Group (JNSPG)'
- Publication date
- Field of study
Nomenclator of Bivalve Families with a Classification of Bivalve Families
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- Adams A.
- Adams H.
- Alencaster G.
- Aliev M. M.
- Alimov A. F.
- Allan J.
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- Allen J. A.
- Amler M.
- Andreescu I.
- Andreescu I.
- Andrusov N.
- Anthony R.
- Anton H. E.
- Appukuttan K. K.
- Arkell W. J.
- Astafieva M. M.
- Astafieva M. M.
- Astafieva-Urbajtis K. A.
- Astafieva-Urbajtis K. A.
- Astafieva-Urbajtis K. A.
- Atkins D.
- Ax P.
- Azuma M.
- Babak E. V.
- Babin C.
- Babin C.
- Badve R. M.
- Beesley P. L.
- Begg J. G.
- Benini C. A.
- Bernard F.
- Bernard F.
- Bernard F. R.
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- Berthold A. A.
- Betekhtina O. A.
- Betekhtina O. A.
- Betekhtina O. A.
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- Beu A. G.
- Beu A. G.
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- Beurlen K.
- Bilotte M.
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- Publication venue
- 'Institute of Malacology'
- Publication date
- Field of study
Kant-Bibliographie 2004
- Author
- Abramjan L. A.
- Abrams Jerolds J
- Airaksinen Siitonen
- Allais Lucy
- Anderson R. Lanier
- Antarkar S. S.
- Anupama A.
- Apel Karl-Otto
- Aquila Richard E
- Araujo Figueiredo
- Augustin GĂŒnther
- Bacin Stefano
- BakraÄeva Albena
- Bal Karol
- Bal Karol
- Bal Karol
- Baranzke Heike
- Barbieri DurĂŁo Aylton
- Bardon Adrian
- Bartuschat Wolfgang
- Bello Eduardo
- Benhabib Seyla
- Benoist Jocelyn
- Berger Maxi
- Bertman Martin
- Bertomeu MarĂa Julia
- Betancourt William D
- Betz John R
- Boboc Alexandru
- Bodea Marcel
- Bonaunet Ketil
- Borges de Meneses Ramiro
- Borges de Meneses Ramiro Delio
- Boyer Alain
- Bozzo Davide
- Brajcic Rudolf
- Brandt Reinhard
- Brandt Reinhard
- Braz Adelina
- Brender Natalie
- BrjuĆĄinkin V. I.
- Brogan Harold W
- Brook Andrew
- Brown Steven Ravett
- Busche Hubertus
- CapeilliĂšres Fabien
- Caranti Luigi
- Carson Emily
- Cassini Charles
- Cassirer Ernst
- Cassirer Ernst
- Cazeaux Clive
- Chackalackal Saju
- Chang Hsueh Chu
- Cherkasova Evgenia V
- Chindea Gabriel
- ChĂĄvarri Eladio
- Clark Michael
- Clark Philip
- Coble Kelly
- Cohen-Halimi MichĂšle
- Coll MĂĄrmol JesĂșs Antonio
- CriĆan Horat
- Croitoru Rodica
- Croitoru Rodica
- Croitoru Rodica
- Croitoru Rodica
- Cunningham David
- CËal'ij V. A.
- Daros William R
- David Pascal
- Deshpande Sharad S
- Dickerson A. B.
- Dillon Robin S
- Dima Teodor
- Dimitrov Ivajlo
- Dimitrov Stefan
- Dimitrova Ina
- Dirschauer Stéphane
- do Kant Hrsg
- Domagala I.
- DonĂ Massimo
- Doyle Tsarina
- Drghici Virgil
- Duque FĂ©lix
- DurĂŁo Aylton Barbieri
- DurĂŁo Fabio Akcelrud
- Dyck Corey W
- DĂŒsing DĂŒsing
- DĂŒsing Klaus
- Ebert Theodor
- Echeverri Santiago
- Engel Eva J
- English Jacques
- Esser Andrea Marlen
- Esteves Julio C. R.
- Fallas Luis Alberto
- Faria Luisa
- Fartos Maximiliano
- Feezell Randolph
- Ferdori Donato
- Ferreira Maria LuĂsa
- Ferrié Christian
- Fichant Michel
- Fieldhouse Heather M
- Fleming Patrick
- Flikschuh Karin
- Florian Mircea
- Flynn E. E.
- Forst Rainer
- Fricke Christel
- Friebe Cord
- Förster Eckart
- Galewicz Wlodzimierz
- Galewicz Wlodzimierz
- Galewicz Wlodzimierz
- Gangavane Deepti
- Gattei Stefano
- Geismann Georg
- Gentile Andrea
- Gentile Andrea
- Ghosh Ranjan K
- Gigliotti Gianna
- Ginsborg Hannah
- Goldberg Nathaniel Jason
- Goldman Avery
- GonzĂĄlez Fisac JesĂșs
- Gotz Gerhard
- Greene Depew
- Greimann Dirk
- Greppi Andrea
- Grueso DelfĂn Ignacio
- Gómez Caffarena José
- Haas Bruno
- Hainz Martin A
- Harré Rom
- Hayden Patrick
- Heinrichs Thomas
- Heinrichs Thomas
- Herbert
- Herold Norbert
- Herrara Restrepo Daniel
- Hindrichs Gunnar
- Hirsch Alfred
- Holden Thomas
- Holtman Sarah Williams
- Howard Jason J
- Howell Robert
- Hruschka Joachim
- Hutter Vernunftglaube
- Höchsmann Hyun
- Immanuel Kant
- Immanuel Kant
- Impulso CiĂȘncias
- Internationale Konferenz
- Irwin Terence
- Ivaldo Marco
- Jacobi Friedrich Heinrich
- Jakic Mirko
- Janiak Andrew
- Jefferson Jaramillo
- Kain Philip J
- Kalinnikov Leonard A
- Kalinnikov Leonard A
- Kanev Alexander
- Kanev Alexander
- Kaniowski Andrzej Maciej
- Kant
- Kant Immanuel
- Kant Immanuel
- Kant Immanuel
- Kant Immanuel
- Kant Immanuel
- Kant Immanuel
- Kanzian Christian
- Kerslake Christian
- Kim Halla
- Kim Jong-Gook
- Kirwan James
- Kitcher Patricia
- Kleingeld Pauline
- Klemme Heiner F
- Klimchuk Dennis
- Kopcek Ivan
- Kopic Mario
- Korsgaard Christine M
- Krasnoff Larry
- Kulenkampff Jens
- Kuliniak Radoslaw
- Kulkarni N. G.
- KuneĆĄ Jan
- KuneĆĄ Jan
- Köhl Harald
- La Rocca Claudio
- Lai Shen Chon
- Landolfi Petrone Giuseppe
- Langton Rae
- Lastra Antonio
- Lawler James
- Leal de Faria Luisa
- Lee Seung-Kee
- Leirfall Anita
- Lema-Hincapié Andrés
- Lerner Xavier
- Lerussi Natalia
- Leyte Arturo
- Liesegang Torsten
- Linebo Oystein
- Longuenesse BĂ©atrice
- LukĂłw Pawel
- LukĂłw Pawel
- LukĂłw Pawel
- Luna Alcoba Manuel
- Lutz-Bachmann Matthias
- LĂłpez DomĂnguez Virginia
- LĂłpez Molina Antonio M
- Macbeth Danielle
- MacFarlane John
- Mahadevan Kanchana
- Marcucci Silvestro
- Marcucci Silvestro
- Margit Ruffing
- Marinas José Miguel
- Marty François
- MartĂnez de Velasco Luis
- MartĂnez Marzoa Felipe
- MartĂnez Marzoa Felipe
- MarĂn Jefferson Jaramillo
- McCarthy Thomas
- McCord Chris
- McDowell John
- McGhee Michael
- Mensch Jennifer
- Meo Oscar
- Merle Jean-Christophe
- Mertens Karl
- Metz Wilhelm
- Meyfeld Dirk
- Miles Murray
- Millgram Elijah
- Mishra Sabhajeet
- Mjasnikov A.
- Mjasnikov A.
- Mohr Georg
- Moretti Laura
- Moretto Antonio
- Morrisson Iain
- Mosbacher Andreas
- Moskopp Walter
- Moura VĂctor
- Moya Eugenio
- Moya Eugenio
- Mueller Volker
- Muguerza Javier
- Murcia Conesa
- Nanti Stefano
- Nit Adrian
- Nnodim Paul
- Nour Soraya
- Nusser Karl-Heinz
- O'Neill Onora
- O'Neill Onora
- Ocampo Rodrigo
- Ogien Ruwen
- Ojzerman Teodor I
- Orend Brian
- Palmer Eric
- Palmer L. M.
- Panknin-Schappert Helke
- Pannerselvam R.
- Panno Giovanni
- Pantea Ana
- Pechar JiĆĂ
- Pechar JiĆĂ
- Peres Daniel Tourinho
- Peter
- Petrovici Ion
- Piché Claude
- Pierce Drew
- Pippin Robert B
- Plata Pineda Oswaldo
- Ponce SĂĄez Antonio
- Pop Adriana
- Popa Delia
- Popescu Victor
- Posch Thomas
- Potepa Maciej
- Pozzo Ricardo
- Prieto Leopoldo
- Procuranti Lucia
- Procuranti Lucia
- Pulley EscĂĄndalo
- Purviance Susan M
- Quero-SĂĄnchez Andres
- Quinn Timothy Sean
- Ramelow Tilman Anselm
- RanciĂšre Jacques
- Reath Andrews
- Recki Birgit
- Reid James
- Rekowitz Nadja
- Religionsphilosophie Hrsg
- Reynolds Scott J
- Ribeiro dos Santos Leonel
- Ribeiro Ferreira Maria Luisa
- Ribeiro Henrique Jales
- Ricken Frido
- Rickless Samuel C
- Riha Rado
- Rivera Castro Faviola
- Rivera de Rosales Jacinto
- Rivera de Rosales Jacinto
- Rivera GarcĂa Antonio
- Robinet André
- RodrĂguez GonzĂĄlez Mariano
- RodrĂquez Tous Juan Antonio
- Rogerson Kenneth F
- Rogerson Kenneth F
- Rohden Valerio
- Rorty Richard
- Rott Hans
- Roullé Antoine
- Rubio Roberto Gustavo
- Ruffing Margit
- Rumanea-Malami Magda
- Rusnock Paul
- Römpp Georg
- Sala Giovanni B
- Sala Giovanni B
- Salucci Alessandro
- Sanil
- Sassen Brigitte
- Sauquillo JuliĂĄn
- Savi Marina
- Schefczyk Michael
- Schmitz Hein-Gerd
- Schneewind Jerome B
- Schnepf Robert
- Schöndorf Harald
- Schöndorf Harald
- Secretan Philibert
- Senderowicz Yaron M
- Serck-Hansen Emilsson
- Setiya Kieran
- Shabel Lisa
- Sieckmann R.
- Siitonen Airaksinen
- Simon Josef
- Singh R. P.
- Soromenho-Marques Viriato
- Sousa Heloisa Helena
- Stankovic Nikola
- Stark Werner
- Stark Werner
- Stevenson Leslie
- Stolzenberg JĂŒrgen
- Streichert Till
- Stroud Scott R
- Surdu Alexandru
- Surdu Alexandru
- Sutherland Daniel
- Sweet William
- Sånchez Fernåndez José Manuel
- SĂĄnchez Meca Diego
- SËumiÄ-Riha Jelica
- Tai Li Jen
- Tatievskaya Elena
- Telegdi Ăron
- Teruel Pedro JesĂșs
- Thomas
- Thomson Garrett
- Thöle Bernhard
- Tomasoni Francesco
- Topalis Ioannis
- Torres SĂĄnchez Hermes RaĂșl
- UjaldĂłn Enrique
- Uleman Jennifer K
- Understanding Kant
- UÄnĂk Lubica
- Valdés Villanueva Luis M
- Vallicella William F
- Van de Vijver Gertrudis
- Vaysse Jean-Marie
- Velleman J. David
- Verhaegh Marcus
- Vidal Javier
- Vilhauer Ben
- Villacañas Berlanga José Luis
- Villacañas Berlanga José Luis
- Villacañas Berlanga José Luis
- Vitiello Vincenzo
- Vlasie Gheorghe
- Volpi Franco
- Wagner Astrid
- Wahsner Renate
- Wang Wen Sheng
- Watkins Eric
- Watkins Eric
- Webb David
- Werner Micha H
- Willaschek Marcus
- Wimmer Reiner
- Wion Matthew
- Wolicka Elzbieta
- Woo Peter
- Woo Peter
- Woudenberg
- Yalçin Sahabettin
- Zanuso F.
- Zehetner Cornelius
- Zenker Georg
- Zizek Slavoj
- ZËelazny Miroslaw
- Publication venue
- 'Walter de Gruyter GmbH'
- Publication date
- Field of study