466 research outputs found
Phaseâmatched secondâharmonic generation by periodic poling of fused silica
90° phase matching in periodically poled fused silica is achieved over approximately 2 mm at a wavelength of 1064 nm. Electrical poling was done at 5 kV for 120 min using photolithographed periodic electrodes on fused silica glass at 250â°C. A nonlinearity equivalent to d 11/200 of quartz is estimated from measurements. Several phaseâmatched interactions are reported and the implications for device applications discussed
Cosmic Ray Acceleration at the Forward Shock in Tycho's Supernova Remnant: Evidence from Chandra X-ray Observations
We present evidence for cosmic ray acceleration at the forward shock in
Tycho's supernova remnant (SNR) from three X-ray observables: (1) the proximity
of the contact discontinuity to the forward shock, or blast wave, (2) the
morphology of the emission from the rim of Tycho, and (3) the spectral nature
of the rim emission. We determine the locations of the blast wave (BW), contact
discontinuity (CD), and reverse shock (RS) around the rim of Tycho's supernova
remnant using a principal component analysis and other methods applied to new
Chandra data. The azimuthal-angle-averaged radius of the BW is 251". For the CD
and RS we find average radii of 241" and 183", respectively. Taking account of
projection effects, we find ratios of 1:0.93:0.70 (BW:CD:RS). We show these
values to be inconsistent with adiabatic hydrodynamical models of SNR
evolution. The CD:BW ratio can be explained if cosmic ray acceleration of ions
is occurring at the forward shock. The RS:BW ratio, as well as the strong Fe Ka
emission from the Tycho ejecta, imply that the RS is not accelerating cosmic
rays. We also extract radial profiles from ~34% of the rim of Tycho and compare
them to models of surface brightness profiles behind the BW for a purely
thermal plasma with an adiabatic shock. The observed morphology of the rim is
much more strongly peaked than predicted by the model, indicating that such
thermal emission is implausible here. Spectral analysis also implies that the
rim emission is non-thermal in nature, lending further support to the idea that
Tycho's forward shock is accelerating cosmic rays.Comment: 39 pages, 10 figures, accepted by Ap
The first NINDS/NIBIB consensus meeting to define neuropathological criteria for the diagnosis of chronic traumatic encephalopathy.
Chronic traumatic encephalopathy (CTE) is a neurodegeneration characterized by the abnormal accumulation of hyperphosphorylated tau protein within the brain. Like many other neurodegenerative conditions, at present, CTE can only be definitively diagnosed by post-mortem examination of brain tissue. As the first part of a series of consensus panels funded by the NINDS/NIBIB to define the neuropathological criteria for CTE, preliminary neuropathological criteria were used by 7 neuropathologists to blindly evaluate 25 cases of various tauopathies, including CTE, Alzheimer's disease, progressive supranuclear palsy, argyrophilic grain disease, corticobasal degeneration, primary age-related tauopathy, and parkinsonism dementia complex of Guam. The results demonstrated that there was good agreement among the neuropathologists who reviewed the cases (Cohen's kappa, 0.67) and even better agreement between reviewers and the diagnosis of CTE (Cohen's kappa, 0.78). Based on these results, the panel defined the pathognomonic lesion of CTE as an accumulation of abnormal hyperphosphorylated tau (p-tau) in neurons and astroglia distributed around small blood vessels at the depths of cortical sulci and in an irregular pattern. The group also defined supportive but non-specific p-tau-immunoreactive features of CTE as: pretangles and NFTs affecting superficial layers (layers II-III) of cerebral cortex; pretangles, NFTs or extracellular tangles in CA2 and pretangles and proximal dendritic swellings in CA4 of the hippocampus; neuronal and astrocytic aggregates in subcortical nuclei; thorn-shaped astrocytes at the glial limitans of the subpial and periventricular regions; and large grain-like and dot-like structures. Supportive non-p-tau pathologies include TDP-43 immunoreactive neuronal cytoplasmic inclusions and dot-like structures in the hippocampus, anteromedial temporal cortex and amygdala. The panel also recommended a minimum blocking and staining scheme for pathological evaluation and made recommendations for future study. This study provides the first step towards the development of validated neuropathological criteria for CTE and will pave the way towards future clinical and mechanistic studies
Relationship between emergency presentation, systemic inflammatory response, and cancer-specific survival in patients undergoing potentially curative surgery for colon cancer
Background
Emergency presentation is recognized to be associated with poorer cancer-specific survival following curative resection for colorectal cancer. The present study examined the hypothesis that an enhanced systemic inflammatory response, prior to surgery, might explain the impact of emergency presentation on survival.
Methods
In all, 188 patients undergoing potentially curative resection for colorectal cancer were studied. Of these, 55 (29%) presented as emergencies. The systemic inflammatory response was assessed using the Glasgow Prognostic Score (mGPS), which is the combination of an elevated C-reactive protein (>10 mg/L) and hypoalbuminemia (<35 g/L).
Results
In the emergency group, tumor stage was greater (P < 0.01), more patients received adjuvant therapy (P < 0.01) more patients had an elevated mGPS (P < 0.01), and more patients died of their disease (P < 0.05). The minimum follow-up was 12 months; the median follow-up of the survivors was 48 months. Emergency presentation was associated with poorer 3-year cancer-specific survival in those patients aged 65 to 74 years (P < 0.01), in both males and females (P < 0.05), in the deprived (P < 0.01), in patients with tumor-node-metastasis (TNM) stage II disease (P < 0.01), in those who received no adjuvant therapy (P < 0.01), and in the mGPS 0 and 1 groups (P < 0.05) groups. On multivariate survival analysis of patients undergoing potentially curative surgery for TNM stage II colon cancer, emergency presentation (P < 0.05) and mGPS (P < 0.05) were independently associated with cancer-specific survival.
Conclusions
These results suggest that emergency presentation and the presence of systemic inflammatory response prior to surgery are linked and account for poorer cancer-specific survival in patients undergoing potentially curative surgery for colon cancer. Both emergency presentation and an elevated mGPS should be taken into account when assessing the likely outcome of these patients
CSU data set of the FIRE marine stratocumulus IFO, The
August 1988.Includes bibliographical references.This research was funded by NASA under grant NAG 1-554 and by ONR under grant N00014-87-K-0228/P00001
Impact of Irminger Rings on Deep Convection in the Labrador Sea : mooring instrument, cruise CTD, and APEX data report September 2007 â September 2009
This is the final data report of all hydrographic station, mooring, and subsurface float data collected by the Woods Hole
Oceanographic Institution in 2007-2009 during the Impact of Irminger Rings on Deep Convection in the Labrador Sea experiment
(IRINGS). The objectives of IRINGS were to (1) to determine the full water column hydrographic and velocity structure of newlyformed
Irminger Rings that have entered the interior Labrador Sea; (2) to observe how Irminger Ring core properties are modified
by atmospheric forcing over their lifetime; and (3) to improve the interpretation of sea surface height (SSH) anomalies in terms of
newly formed coherent heat containing Irminger Rings. The mooring deployment and recovery cruises were both on the R/V
Knorr: KN192-01 in September 2007 and KN196-01 in September 2009, respectively. The single mooring held eight Aanderaa
current meters (RCM-11), two Submerged Autonomous Launch Platforms (SALPs), and nine Seabird microcats (SBE37),
deployed from 26 September 2007 through 27 September 2009, yeilding full water column (100-3000 meters) records of
temperature, salinity, pressure, and velocity data for the two year period. The two SALP cages contained eleven APEX floats, and
released some of these floats according to local oceanographic conditions, so as to seed the floats in passing Irminger Rings, and
the remainder of floats as timed releases. Thirteen conductivity-temperature-depth (CTD) stations were taken on the mooring
recovery cruise, creating a boundary current cross-section from the mooring site to Nuuk, Greenland.Funding was provided by the National Science Foundation
Grant OCE-0623192
CSU tethered balloon data set of the FIRE marine stratocumulus IFO, The
November, 1988.Includes bibliographical references.Funding agencies: National Aeronautics and Space Administration, Office of Naval Research. This research was funded by ONR under grant N00014-87-K-0228/P00001 and by NASA under grant NAG 1-554
A disk of dust and molecular gas around a high-mass protostar
The processes leading to the birth of low-mass stars such as our Sun have
been well studied, but the formation of high-mass (> 8 x Sun's mass) stars has
heretofore remained poorly understood. Recent observational studies suggest
that high-mass stars may form in essentially the same way as low-mass stars,
namely via an accretion process, instead of via merging of several low-mass (<
8 Msun) stars. However, there is as yet no conclusive evidence. Here, we report
the discovery of a flattened disk-like structure observed at submillimeter
wavelengths, centered on a massive 15 Msun protostar in the Cepheus-A region.
The disk, with a radius of about 330 astronomical units (AU) and a mass of 1 to
8 Msun, is detected in dust continuum as well as in molecular line emission.
Its perpendicular orientation to, and spatial coincidence with the central
embedded powerful bipolar radio jet, provides the best evidence yet that
massive stars form via disk accretion in direct analogy to the formation of
low-mass stars
Pollutant dispersion in a developing valley cold-air pool
Pollutants are trapped and accumulate within cold-air pools, thereby affecting air quality. A numerical model is used to quantify the role of cold-air-pooling processes in the dispersion of air pollution in a developing cold-air pool within an alpine valley under decoupled stable conditions. Results indicate that the negatively buoyant downslope flows transport and mix pollutants into the valley to depths that depend on the temperature deficit of the flow and the ambient temperature structure inside the valley. Along the slopes, pollutants are generally entrained above the cold-air pool and detrained within the cold-air pool, largely above the ground-based inversion layer. The ability of the cold-air pool to dilute pollutants is quantified. The analysis shows that the downslope flows fill the valley with air from above, which is then largely trapped within the cold-air pool, and that dilution depends on where the pollutants are emitted with respect to the positions of the top of the ground-based inversion layer and cold-air pool, and on the slope wind speeds. Over the lower part of the slopes, the cold-air-pool-averaged concentrations are proportional to the slope wind speeds where the pollutants are emitted, and diminish as the cold-air pool deepens. Pollutants emitted within the ground-based inversion layer are largely trapped there. Pollutants emitted farther up the slopes detrain within the cold-air pool above the ground-based inversion layer, although some fraction, increasing with distance from the top of the slopes, penetrates into the ground-based inversion layer.Peer reviewe
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