Happiness Drives Performance

The article of record as published may be found at https://markets.businessinsider.com/news/stocks/happiness-drives-performance-103120049

Correspondence between discrete and piecewise linear models of gene regulatory networks

International audienceWe know that some proteins can regulate the expression of genes in a living organism. The regulation of gene expression occurs through networks of regulatory interactions in a non linear way between DNA, RNA, proteins and some molecules, called genetic regulatory networks. It is becoming clear that mathematical models and tools are required to analyze these complex systems. In the course of his study on gene regulatory networks R. Thomas proposed a discrete framework that mimics the qualitative evolution of such systems. Such discrete models are of great importance because kinetic parameters are often non measurable in vivo and available data are often of qualitative nature. Then Snoussi proved consistency between the discrete approach of R. Thomas and Piecewise Linear Differential Equation Systems, which are easy to construct from interaction graph and thresholds of interactions. Our work focuses on the relationships between both approaches: we will prove a result of correspondence between the two models. Finally, we will give some short description of a Maple program which can compute a discrete path, given the ordinary differential equation and starting box

Non-invasive vagus nerve stimulation for primary headache: A clinical update.

Background Non-invasive vagus nerve stimulation (nVNS) is a proven treatment for cluster headache and migraine. Several possible mechanisms of action by which nVNS mitigates headache have been identified. Methods We conducted a narrative review of recent scientific and clinical research into nVNS for headache, including findings from mechanistic studies and their possible relationships to the clinical effects of nVNS. Results Findings from animal and human studies have provided possible mechanistic explanations for nVNS efficacy in headache involving four core areas: Autonomic nervous system functions; cortical spreading depression inhibition; neurotransmitter regulation; and nociceptive modulation. We discuss how overlap and interplay among these areas may underlie the utility of nVNS in the context of clinical evidence supporting its safety and efficacy as acute and preventive therapy for both cluster headache and migraine. Possible future nVNS applications are also discussed. Conclusion Significant progress over the past several years has yielded valuable mechanistic and clinical evidence that, combined with the excellent safety and tolerability profile of nVNS, suggests that it should be considered a first-line treatment for both acute and preventive treatment of cluster headache, an effective option for acute treatment of migraine, and a highly relevant, practical option for migraine prevention

Happy Soldiers are Highest Performers

17 USC 105 interim-entered record; under review.The article of record as published may be found at: https://doi.org/10.1007/s10902-021-00441-xWe examined the prediction of affective well-being to work performance in the United States Army. We found that high positive affect (PA), low negative affect (NA), and high optimism predicted awards for performance and heroism in a sample of 908,096 U.S. Army soldiers (mean age 29.60 years old, SD = 9.16 years; with over 1⁄4 of a million ethnic minor- ities and over 150,000 women). Baseline high PA, low NA, and high optimism predicted awards over a four-year follow up window, in which 114,443 soldiers (12.60%) received an award. Each well-being variable predicted future awards for both women and men, for enlisted soldiers as well as officers, for several ethnicities, for varying levels of education, and controlling for a number of other potential explanatory variables. The effects of high positive and low negative affect were additive, with each predicting significantly beyond the other. Comparing the soldiers highest vs. lowest in well-being predicted an almost four- fold greater award recognition in the high group. Awards were predicted by both high and low arousal positive emotions, as well as low sadness and low anger. The relations between PA, NA, and optimism with award attainment were curvilinear, with the greatest difference in award attainment occurring between low and moderate levels of affective well-being, with little effect between moderate and high well-being.Identified in text as U.S. Government work

Centre d’études africaines – CEAf

Jean Copans, professeur à l’Université Paris-V/DescartesIngolf Diener, maître de conférences à l’Université Paris-VIII/Vincennes-Saint-DenisRoger Meunier, ingénieur d’études État, sociétés et problèmes sociaux en Afrique australe Dans la continuité des années précédentes, le séminaire poursuit l’analyse de la dynamique des relations socio-économiques, politiques et culturelles en Afrique du Sud, en Namibie, en Angola et au Mozambique. Tout en étant attentifs aux continuités et aux ruptures pa..

Centre d’études africaines – CEAf

Jean Copans, professeur à l’Université Paris-V/DescartesIngolf Diener, maître de conférences à l’Université Paris-VIII/Vincennes-Saint-DenisRoger Meunier, ingénieur d’études État, sociétés et problèmes sociaux en Afrique australe Dans la continuité des années précédentes, le séminaire poursuit l’analyse de la dynamique des relations socio-économiques, politiques et culturelles en Afrique du Sud, en Namibie, en Angola et au Mozambique. Tout en étant attentifs aux continuités et aux ruptures pa..

Prosocial Spending and Well-Being: Cross-Cultural Evidence for a Psychological Universal

This research provides the first support for a possible psychological universal: human beings around the world derive emotional benefits from using their financial resources to help others (prosocial spending). Analyzing survey data from 136 countries, we show that prosocial spending is consistently associated with greater happiness. To test for causality, we conduct experiments within two very different countries (Canada and Uganda) and show that spending money on others has a consistent, causal impact on happiness. In contrast to traditional economic thought—which places self-interest as the guiding principle of human motivation—our findings suggest that the reward experienced from helping others may be deeply ingrained in human nature, emerging in diverse cultural and economic contexts.

A Comparison of Atrial Fibrillation Monitoring Strategies After Cryptogenic Stroke (from the Cryptogenic Stroke and Underlying AF Trial)

Ischemic stroke cause remains undetermined in 30% of cases, leading to a diagnosis of cryptogenic stroke. Paroxysmal atrial fibrillation (AF) is a major cause of ischemic stroke but may go undetected with short periods of ECG monitoring. The Cryptogenic Stroke and Underlying Atrial Fibrillation trial (CRYSTAL AF) demonstrated that long-term electrocardiographic monitoring with insertable cardiac monitors (ICM) is superior to conventional follow-up in detecting AF in the population with cryptogenic stroke. We evaluated the sensitivity and negative predictive value (NPV) of various external monitoring techniques within a cryptogenic stroke cohort. Simulated intermittent monitoring strategies were compared to continuous rhythm monitoring in 168 ICM patients of the CRYSTAL AF trial. Short-term monitoring included a single 24-hour, 48-hour, and 7-day Holter and 21-day and 30-day event recorders. Periodic monitoring consisted of quarterly monitoring through 24-hour, 48-hour, and 7-day Holters and monthly 24-hour Holters. For a single monitoring period, the sensitivity for AF diagnosis was lowest with a 24-hour Holter (1.3%) and highest with a 30-day event recorder (22.8%). The NPV ranged from 82.3% to 85.6% for all single external monitoring strategies. Quarterly monitoring with 24-hour Holters had a sensitivity of 3.1%, whereas quarterly 7-day monitors increased the sensitivity to 20.8%. The NPVs for repetitive periodic monitoring strategies were similar at 82.6% to 85.3%. Long-term continuous monitoring was superior in detecting AF compared to all intermittent monitoring strategies evaluated (p <0.001). Long-term continuous electrocardiographic monitoring with ICMs is significantly more effective than any of the simulated intermittent monitoring strategies for identifying AF in patients with previous cryptogenic stroke

Scanned Potential Microscopy of Edge and Bulk Currents in the Quantum Hall Regime

Using an atomic force microscope as a local voltmeter, we measure the Hall voltage profile in a 2D electron gas in the quantum Hall (QH) regime. We observe a linear profile in the bulk of the sample in the transition regions between QH plateaus and a distinctly nonlinear profile on the plateaus. In addition, localized voltage drops are observed at the sample edges in the transition regions. We interpret these results in terms of theories of edge and bulk currents in the QH regime.Comment: 4 pages, 5 figure

Thrombolytic removal of intraventricular haemorrhage in treatment of severe stroke: results of the randomised, multicentre, multiregion, placebo-controlled CLEAR III trial

Background: Intraventricular haemorrhage is a subtype of intracerebral haemorrhage, with 50% mortality and serious disability for survivors. We aimed to test whether attempting to remove intraventricular haemorrhage with alteplase versus saline irrigation improved functional outcome. Methods: In this randomised, double-blinded, placebo-controlled, multiregional trial (CLEAR III), participants with a routinely placed extraventricular drain, in the intensive care unit with stable, non-traumatic intracerebral haemorrhage volume less than 30 mL, intraventricular haemorrhage obstructing the 3rd or 4th ventricles, and no underlying pathology were adaptively randomly assigned (1:1), via a web-based system to receive up to 12 doses, 8 h apart of 1 mg of alteplase or 0·9% saline via the extraventricular drain. The treating physician, clinical research staff, and participants were masked to treatment assignment. CT scans were obtained every 24 h throughout dosing. The primary efficacy outcome was good functional outcome, defined as a modified Rankin Scale score (mRS) of 3 or less at 180 days per central adjudication by blinded evaluators. This study is registered with ClinicalTrials.gov, NCT00784134. Findings: Between Sept 18, 2009, and Jan 13, 2015, 500 patients were randomised: 249 to the alteplase group and 251 to the saline group. 180-day follow-up data were available for analysis from 246 of 249 participants in the alteplase group and 245 of 251 participants in the placebo group. The primary efficacy outcome was similar in each group (good outcome in alteplase group 48% vs saline 45%; risk ratio [RR] 1·06 [95% CI 0·88–1·28; p=0·554]). A difference of 3·5% (RR 1·08 [95% CI 0·90–1·29], p=0·420) was found after adjustment for intraventricular haemorrhage size and thalamic intracerebral haemorrhage. At 180 days, the treatment group had lower case fatality (46 [18%] vs saline 73 [29%], hazard ratio 0·60 [95% CI 0·41–0·86], p=0·006), but a greater proportion with mRS 5 (42 [17%] vs 21 [9%]; RR 1·99 [95% CI 1·22–3·26], p=0·007). Ventriculitis (17 [7%] alteplase vs 31 [12%] saline; RR 0·55 [95% CI 0·31–0·97], p=0·048) and serious adverse events (114 [46%] alteplase vs 151 [60%] saline; RR 0·76 [95% CI 0·64–0·90], p=0·002) were less frequent with alteplase treatment. Symptomatic bleeding (six [2%] in the alteplase group vs five [2%] in the saline group; RR 1·21 [95% CI 0·37–3·91], p=0·771) was similar. Interpretation: In patients with intraventricular haemorrhage and a routine extraventricular drain, irrigation with alteplase did not substantially improve functional outcomes at the mRS 3 cutoff compared with irrigation with saline. Protocol-based use of alteplase with extraventricular drain seems safe. Future investigation is needed to determine whether a greater frequency of complete intraventricular haemorrhage removal via alteplase produces gains in functional status