Early Stages of Homopolymer Collapse

Interest in the protein folding problem has motivated a wide range of theoretical and experimental studies of the kinetics of the collapse of flexible homopolymers. In this Paper a phenomenological model is proposed for the kinetics of the early stages of homopolymer collapse following a quench from temperatures above to below the theta temperature. In the first stage, nascent droplets of the dense phase are formed, with little effect on the configurations of the bridges that join them. The droplets then grow by accreting monomers from the bridges, thus causing the bridges to stretch. During these two stages the overall dimensions of the chain decrease only weakly. Further growth of the droplets is accomplished by the shortening of the bridges, which causes the shrinking of the overall dimensions of the chain. The characteristic times of the three stages respectively scale as the zeroth, 1/5 and 6/5 power of the the degree of polymerization of the chain.Comment: 11 pages, 3 figure

Continuous Space-Bounded Non-Malleable Codes from Stronger Proofs-of-Space

Non-malleable codes are encoding schemes that provide protections against various classes of tampering attacks. Recently Faust et al. (CRYPTO 2017) initiated the study of space- bounded non-malleable codes that provide such protections against tampering within small- space devices. They put forward a construction based on any non-interactive proof-of-space (NIPoS). However, the scheme only protects against an a priori bounded number of tampering attacks. We construct non-malleable codes that are resilient to an unbounded polynomial number of space-bounded tamperings. Towards that we introduce a stronger variant of NIPoS called proof-extractable NIPoS (PExt-NIPoS), and propose two approaches of constructing such a primitive. Using a new proof strategy we show that the generic encoding scheme of Faust et al. achieves unbounded tamper-resilience when instantiated with a PExt-NIPoS. We show two methods to construct PExt-NIPoS: 1. The first method uses a special family of “memory-hard” graphs, called challenge-hard graphs (CHG), a notion we introduce here. We instantiate such family of graphs based on an extension of stack of localized expanders (first used by Ren and Devadas in the context of proof-of-space). In addition, we show that the graph construction used as a building block for the proof-of-space by Dziembowski et al. (CRYPTO 2015) satisfies challenge-hardness as well. These two CHG-instantiations lead to continuous space-bounded NMC with different features in the random oracle model. 2. Our second instantiation relies on a new measurable property, called uniqueness of NIPoS. We show that standard extractability can be upgraded to proof-extractability if the NIPoS also has uniqueness. We propose a simple heuristic construction of NIPoS, that achieves (partial) uniqueness, based on a candidate memory-hard function in the standard model and a publicly verifiable computation with small-space verification. Instantiating the encoding scheme of Faust et al. with this NIPoS, we obtain a continuous space-bounded NMC that supports the “most practical” parameters, complementing the provably secure but “relatively impractical” CHG-based constructions. Additionally, we revisit the construction of Faust et al. and observe that due to the lack of uniqueness of their NIPoS, the resulting encoding schemes yield “highly impractical” parameters in the continuous setting. We conclude the paper with a comparative study of all our non-malleable code constructions with an estimation of concrete parameters

The role of platelets in the recruitment of leukocytes during vascular disease

Besides their role in the formation of thrombus during haemostasis, it is becoming clear that platelets contribute to a number of other processes within the vasculature. Indeed, the integrated function of the thrombotic and inflammatory systems, which results in platelet-mediated recruitment of leukocytes, is now considered to be of great importance in the propagation, progression and pathogenesis of atherosclerotic disease of the arteries. There are three scenarios by which platelets can interact with leukocytes: (1) during haemostasis, when platelets adhere to and are activated on sub-endothelial matrix proteins exposed by vascular damage and then recruit leukocytes to a growing thrombus. (2) Platelets adhere to and are activated on stimulated endothelial cells and then bridge blood borne leukocytes to the vessel wall and. (3) Adhesion between platelets and leukocytes occurs in the blood leading to formation of heterotypic aggregates prior to contact with endothelial cells. In the following review we will not discuss leukocyte recruitment during haemostasis, as this represents a physiological response to tissue trauma that can progress, at least in its early stages, in the absence of inflammation. Rather we will deal with scenarios 2 and 3, as these pathways of platelet–leukocyte interactions are important during inflammation and in chronic inflammatory diseases such as atherosclerosis. Indeed, these interactions mean that leukocytes possess means of adhesion to the vessel wall under conditions that may not normally be permissive of leukocyte–endothelial cell adhesion, meaning that the disease process may be able to bypass the regulatory pathways which would ordinarily moderate the inflammatory response

Pre-Cenomanian Cheilostome Bryozoa : Current State of Knowledge

This paper briefly summarizes published and new data on the occurrences of pre-Cenomanian cheilostome Bryozoa following their first appearance in the Late Jurassic. We tabulate all known taxa chronologically, summarize stratigraphical and geographical distributions, and comment on the main morphological innovations that appeared in pre-Cenomanian times. Most early cheilostomes are classified in the suborder Malacostegina. Early cheilostomes were morphologically simple and low in diversity, but were geographically widespread. These features can be explained by the possession of a long-living planktotrophic larval stage, as in Recent malacostegans. Diversification of the suborder Neocheilostomina, which greatly dominates modern and post-Albian bryozoan faunas, began in the Late Albian and coincided with the origin of brood chambers (ovicells) and a presumably short-lived, non-planktotrophic larva. The presence of Late Albian neocheilostomes in both Europe and North America implies that their brief larval life was not an obstacle to achieving a wide distribution and suggests a role for rafting in their dispersal.International Symposium, "The Origin and Evolution of Natural Diversity". 1–5 October 2007. Sapporo, Japan

Catchment land use and trophic state impacts on phytoplankton composition: a case study from the Rotorua lakes’ district, New Zealand

Trophic state of lakes has been related to catchment land use, but direct links between phytoplankton taxa and land use are limited. Phytoplankton composition, represented by relative cell abundance of phyla, was measured over a period of 4 years in 11 lakes in the Rotorua region, New Zealand. The lakes differed in morphometry, trophic state and land use (as percentage catchment area). We tested whether relative proportion of land uses, indirectly representing relative nutrient loading, was the overarching driver of phytoplankton composition. Trophic state was correlated negatively with native forest and positively with pasture and urban area. Cyanoprokaryota were correlated negatively with native forest and positively with pasture and trophic state, Chlorophyta were correlated positively with native forest and urban land use and negatively with pasture and trophic state, and Bacillariophyta were positively correlated with dissolved reactive silica to dissolved inorganic nitrogen (Si:DIN) and Si to dissolved reactive phosphorus (Si:DRP) ratios. Lakes with higher nutrient loads had higher trophic state and Cyanoprokaryota dominance. Chlorophyta were negatively correlated with Cyanoprokaryota and Bacillariophyta, suggesting competition amongst these groups. Our results apply to lakes potentially subject to changes in catchment land use, which may have implications for trophic state, phytoplankton composition and Cyanoprokaryota blooms

Taxonomy, ecology and zoogeography of the Recent species of Rhamphostomella Lorenz, 1886 and Mixtoscutella n. gen. (Bryozoa, Cheilostomata)

Grischenko, Andrei V., Gordon, Dennis P., Taylor, Paul D., Kuklinski, Piotr, Denisenko, Nina V., Spencer-Jones, Mary E., Ostrovsky, Andrew N. (2022): Taxonomy, ecology and zoogeography of the Recent species of Rhamphostomella Lorenz, 1886 and Mixtoscutella n. gen. (Bryozoa, Cheilostomata). Zootaxa 5131 (1): 1-115, DOI: https://doi.org/10.11646/zootaxa.5131.1.1, URL: http://dx.doi.org/10.11646/zootaxa.5131.1.