Effects of cardiac resynchronization therapy on health-related quality of life in older adults with heart failure

The aim of the study was to examine changes in health-related quality of life among older adults undergoing cardiac resynchronization therapy (CRT), a pacemaker based intervention for heart failure. Twenty-one patients (mean age = 68; SD = 8) completed measures of cardiovascular health and quality of life prior to and 3-months post-CRT. Following the intervention, patients reported improvements in their perception of their physical functioning (t = 2.8, p < 0.01) and feelings of vitality (t = 2.9, p < 0.01) on the MOS SF-36 Health Survey. Patients improved on objective clinical measures of exercise capacity, cardiac ejection fraction, and ventricular dyssynchrony. Younger patients reported greater improvements in physical functioning and decreases in pain. Higher baseline body mass index was associated with less improvement in physical functioning. Finally, patients with nonischemic heart failure reported greater improvements on multiple subscales of the SF-36 than patients with ischemic heart failure. This preliminary study documented improvements in health-related quality of life following CRT. The findings highlight that specific patient characteristics may be associated with quality of life changes. Future studies will benefit from including quality of life measures that assess multiple health-related domains

Cosmic Ray Acceleration at the Forward Shock in Tycho's Supernova Remnant: Evidence from Chandra X-ray Observations

We present evidence for cosmic ray acceleration at the forward shock in Tycho's supernova remnant (SNR) from three X-ray observables: (1) the proximity of the contact discontinuity to the forward shock, or blast wave, (2) the morphology of the emission from the rim of Tycho, and (3) the spectral nature of the rim emission. We determine the locations of the blast wave (BW), contact discontinuity (CD), and reverse shock (RS) around the rim of Tycho's supernova remnant using a principal component analysis and other methods applied to new Chandra data. The azimuthal-angle-averaged radius of the BW is 251". For the CD and RS we find average radii of 241" and 183", respectively. Taking account of projection effects, we find ratios of 1:0.93:0.70 (BW:CD:RS). We show these values to be inconsistent with adiabatic hydrodynamical models of SNR evolution. The CD:BW ratio can be explained if cosmic ray acceleration of ions is occurring at the forward shock. The RS:BW ratio, as well as the strong Fe Ka emission from the Tycho ejecta, imply that the RS is not accelerating cosmic rays. We also extract radial profiles from ~34% of the rim of Tycho and compare them to models of surface brightness profiles behind the BW for a purely thermal plasma with an adiabatic shock. The observed morphology of the rim is much more strongly peaked than predicted by the model, indicating that such thermal emission is implausible here. Spectral analysis also implies that the rim emission is non-thermal in nature, lending further support to the idea that Tycho's forward shock is accelerating cosmic rays.Comment: 39 pages, 10 figures, accepted by Ap

The Chandra Multi-Wavelength Project: Optical Spectroscopy and the Broadband Spectral Energy Distributions of X-ray Selected AGN

From optical spectroscopy of X-ray sources observed as part of ChaMP, we present redshifts and classifications for a total of 1569 Chandra sources from our targeted spectroscopic follow up using the FLWO, SAAO, WIYN, CTIO, KPNO, Magellan, MMT and Gemini telescopes, and from archival SDSS spectroscopy. We classify the optical counterparts as 50% BLAGN, 16% NELG, 14% ALG, and 20% stars. We detect QSOs out to z~5.5 and galaxies out to z~3. We have compiled extensive photometry from X-ray to radio bands. Together with our spectroscopic information, this enables us to derive detailed SEDs for our extragalactic sources. We fit a variety of templates to determine bolometric luminosities, and to constrain AGN and starburst components where both are present. While ~58% of X-ray Seyferts require a starburst event to fit observed photometry only 26% of the X-ray QSO population appear to have some kind of star formation contribution. This is significantly lower than for the Seyferts, especially if we take into account torus contamination at z>1 where the majority of our X-ray QSOs lie. In addition, we observe a rapid drop of the percentage of starburst contribution as X-ray luminosity increases. This is consistent with the quenching of star formation by powerful QSOs, as predicted by the merger model, or with a time lag between the peak of star formation and QSO activity. We have tested the hypothesis that there should be a strong connection between X-ray obscuration and star-formation but we do not find any association between X-ray column density and star formation rate both in the general population or the star-forming X-ray Seyferts. Our large compilation also allows us to report here the identification of 81 XBONG, 78 z>3 X-ray sources and 8 Type-2 QSO candidates. Also we have identified the highest redshift (z=5.4135) X-ray selected QSO with optical spectroscopy.Comment: 17 pages, 16 figures, accepted for publication in ApJS. Full data table and README file can be found online at http://hea-www.harvard.edu/~pgreen/Papers.htm

Interacting galaxies on FIRE-2: The connection between enhanced star formation and interstellar gas content

We present a comprehensive suite of high-resolution (parsec-scale), idealised (non-cosmological) galaxy merger simulations (24 runs, stellar mass ratio ~2.5:1) to investigate the connection between interaction-induced star formation and the evolution of the interstellar medium (ISM) in various temperature-density regimes. We use the GIZMO code and the second version of the 'Feedback in Realistic Environments' model (FIRE-2), which captures the multi-phase structure of the ISM. Our simulations are designed to represent galaxy mergers in the local Universe. In this work, we focus on the 'galaxy-pair period' between first and second pericentric passage. We split the ISM into four regimes: hot, warm, cool and cold-dense, motivated by the hot, ionised, atomic and molecular gas phases observed in real galaxies. We find that, on average, interactions enhance the star formation rate of the pair (~30%, merger-suite sample average) and elevate their cold-dense gas content (~18%). This is accompanied by a decrease in warm gas (~11%), a negligible change in cool gas (~4% increase), and a substantial increase in hot gas (~400%). The amount of cold-dense gas with densities above 1000 cm^3 (the cold ultra-dense regime) is elevated significantly (~240%), but only accounts for 0.15% (on average) of the cold-dense gas budget.Comment: 21 pages, 17 figures, accepted by MNRA

Three intervening galaxy absorbers towards GRB060418: faint and dusty?

We present an analysis of three strong, intervening Mg II absorption systems (z_abs = 0.603, 0.656, 1.107) towards the optical afterglow of gamma-ray burst (GRB) 060418. From high resolution UVES spectra we measure metal column densities and find that the highest redshift absorber exhibits a large amount of dust depletion compared with DLAs seen in QSO spectra. The intervening z_abs = 1.107 absorber is also unusual in exhibiting a clear 2175 A bump, the first time this feature has been definitively detected in a GRB spectrum. The GRB afterglow spectrum is best fit with a two component extinction curve: an SMC extinction law at z=1.49 (the redshift of the host) with E(B-V) = 0.07+-0.01 and a Galactic extinction curve at z ~ 1.1 with E(B-V) = 0.08+-0.01. We also present a moderately deep NTT R-band image of the GRB060418 field and spectroscopy of four galaxies within 1 arcminute. None of these objects has a redshift that matches any of the intervening absorbers, and we conclude that the galaxies responsible for the two intervening Mg II absorbers at z ~ 0.6 have luminosities ~<0.3 L^star.Comment: Accepted for publication in MNRAS (Letters), 5 pages. Updated with more accurate host positio

Pollutant dispersion in a developing valley cold-air pool

Pollutants are trapped and accumulate within cold-air pools, thereby affecting air quality. A numerical model is used to quantify the role of cold-air-pooling processes in the dispersion of air pollution in a developing cold-air pool within an alpine valley under decoupled stable conditions. Results indicate that the negatively buoyant downslope flows transport and mix pollutants into the valley to depths that depend on the temperature deficit of the flow and the ambient temperature structure inside the valley. Along the slopes, pollutants are generally entrained above the cold-air pool and detrained within the cold-air pool, largely above the ground-based inversion layer. The ability of the cold-air pool to dilute pollutants is quantified. The analysis shows that the downslope flows fill the valley with air from above, which is then largely trapped within the cold-air pool, and that dilution depends on where the pollutants are emitted with respect to the positions of the top of the ground-based inversion layer and cold-air pool, and on the slope wind speeds. Over the lower part of the slopes, the cold-air-pool-averaged concentrations are proportional to the slope wind speeds where the pollutants are emitted, and diminish as the cold-air pool deepens. Pollutants emitted within the ground-based inversion layer are largely trapped there. Pollutants emitted farther up the slopes detrain within the cold-air pool above the ground-based inversion layer, although some fraction, increasing with distance from the top of the slopes, penetrates into the ground-based inversion layer.Peer reviewe

Bridging Alone: Religious Conservatism, Marital Homogamy, and Voluntary Association Membership

This study characterizes social insularity of religiously conservative American married couples by examining patterns of voluntary associationmembership. Constructing a dataset of 3938 marital dyads from the second wave of the National Survey of Families and Households, the author investigates whether conservative religious homogamy encourages membership in religious voluntary groups and discourages membership in secular voluntary groups. Results indicate that couples’ shared affiliation with conservative denominations, paired with beliefs in biblical authority and inerrancy, increases the likelihood of religious group membership for husbands and wives and reduces the likelihood of secular group membership for wives, but not for husbands. The social insularity of conservative religious groups appears to be reinforced by homogamy—particularly by wives who share faith with husbands