Network mechanisms underlying motor control after ischemic stroke

Motor impairment is one of the most common symptoms after ischemic stroke. While many patients partially regain lost functions due to plastic changes to the structural and functional architecture of brain networks, recovery is often incomplete, making stroke a leading cause of long-term disability worldwide. Thus, a better mechanistic understanding of motor recovery seems crucial to inform future plasticity-enhancing treatment approaches. The studies summarized in the present thesis therefore aimed at furthering our mechanistic insights into motor network reorganization in acute and chronic stroke patients. In study 1, we focused on the role of different descending motor pathways on distinct aspects of motor control. Study 2 addressed the role of corticospinal output fibers descending from the primary motor cortex (M1) and various premotor areas. In study 3, we assessed cortico-cortical structural connectivity and its differential association with basal and complex motor functions. Finally, study 4 utilized fMRI-data from acute stroke patients to conduct the first direct comparison of resting-state functional and task-related effective connectivity. Taken together, our findings offer novel insights into mechanisms underlying motor control after stroke and hold important implications for therapeutic interventions

Determination of metal ion content of beverages and estimation of target hazard quotients : a comparative study

Background: Considerable research has been directed towards the roles of metal ions in nutrition with metal ion toxicity attracting particular attention. The aim of this study is to measure the levels of metal ions found in selected beverages (red wine, stout and apple juice) and to determine their potential detrimental effects via calculation of the Target Hazard Quotients (THQ) for 250 mL daily consumption. Results: The levels (mean ± SEM) and diversity of metals determined by ICP-MS were highest for red wine samples (30 metals totalling 5620.54 ± 123.86 ppb) followed by apple juice (15 metals totalling 1339.87 ± 10.84 ppb) and stout (14 metals totalling 464.85 ± 46.74 ppb). The combined THQ values were determined based upon levels of V, Cr, Mn, Ni, Cu, Zn and Pb which gave red wine samples the highest value (5100.96 ± 118.93 ppb) followed by apple juice (666.44 ± 7.67 ppb) and stout (328.41 ± 42.36 ppb). The THQ values were as follows: apple juice (male 3.11, female 3.87), stout (male 1.84, female 2.19), red wine (male 126.52, female 157.22) and ultra-filtered red wine (male 110.48, female 137.29). Conclusion: This study reports relatively high levels of metal ions in red wine, which give a very high THQ value suggesting potential hazardous exposure over a lifetime for those who consume at least 250 mL daily. In addition to the known hazardous metals (e.g. Pb), many metals (e.g. Rb) have not had their biological effects systematically investigated and hence the impact of sustained ingestion is not known

Clean Water for Less Integrated Planning Reduces the Cost of Meeting Water Quality Goals in New Hampshire

Rising populations and increased development in New Hampshire coastal communities have led to a decline in water quality in the Great Bay Estuary. Responding effectively and affordably to new federal permit requirements for treating and discharging stormwater and wastewater will require innovative solutions from communities in the area. The Water Integration for Squamscott-Exeter (WISE) project developed an integrated planning framework through which the coastal communities of Exeter, Stratham, and Newfields could significantly reduce the cost of meeting permit requirements. In this brief, authors Alison Watts, Robert Roseen, Paul Stacey, Renee Bourdeau, and Theresa Walker report that integrated planning could save these communities over $100 million (in fifty-year lifecycle costs) by prioritizing high-impact, low-cost mitigation strategies across permit type and town boundaries. The project, which has received an Environmental Merit award from Environment Protection Agency, also found that attainment of water quality standards in the Exeter–Squamscott River will not be possible without substantial cooperation and investment from upstream communities, which are not currently subject to EPA permit requirements. Collaboration among communities in planning and implementing projects to meet clean water regulations can have significant cost and effectiveness benefits

Acquisition of acid vapor and aerosol concentration data for use in dry deposition studies in the South Coast Air Basin

An atmospheric monitoring network was operated throughout the South Coast Air Basin in the greater Los Angeles area during the year 1986. The primary objective of this study was to measure the spatial and temporal concentration distributions of atmospheric gas phase and particulate phase acids and bases in support of the California Air Resources Board's dry deposition research program. Gaseous pollutants measured include HNO_3, HCl, HF, HBr, formic acid, acetic acid and ammonia. The chemical composition of the airborne particulate matter complex was examined in three size ranges: fine particles (less than 2.2 μm aerodynamic diameter, AD), PM_(10) (less than 10 μm AD) and total particles (no size discrimination). Upwind of the air basin at San Nicolas Island, gas phase acids concentrations are very low: averaging 0.3 μg m^(-3) (0.1 ppb) for HNO_3, 0.8 μg m^(-3) for HCl, 0.13 μg m^(-3) for HF, and 2.6 μg m^(-3) for formic acid. Annual average HN03 concentrations ranged from 3.1 μg m^(-3) (1.2 ppb) near the Southern California coast to 6.9 μg m^(-3) (2.7 ppb) at an inland site in the San Gabriel Mountains. HCl concentrations within the South Coast Air Basin averaged from 0.8 μg m^(-3) to 1.8 μg m^(-3) during the year 1986. Long-term average HF concentrations within the air basin are very low, in the range from 0.14 to 0.22 μg m^(-3) between monitoring sites. Long-term average formic acid concentrations are lowest near the coastline (5.0 μg m^(-3) at Hawthorne), with the highest average concentrations (10.7 μg m^(-3)) observed inland at Upland. Ammonia concentrations at low elevation within the South Coast Air Basin average from 2.1 μg m^(-3) to 4.4 μg m^(-3) at all sites except Rubidoux. Rubidoux is located directly downwind of a large ammonia source created by dairy farming and other agricultural activities in the Chino area. Ammonia concentrations at Rubidoux average 30 μg m^(-3) during 1986, a factor of approximately 10 higher than elsewhere in the air basin. Annual average PM_(10) mass concentrations within the South Coast Air Basin ranged from 47.0 μg m^(-3) along the coast to 87.4 μg m^(-3) at Rubidoux, the farthest inland monitoring site. Five major aerosol components (carbonaceous material, NO_3^-, SO_4^-, NH_4^+ and soil-related material) accounted for greater than 80% of the annual average PM_(10) mass concentration at all on-land monitoring stations. A peak 24-h average PM_(10) mass concentration of 299 μg m^(-3) was observed at Rubidoux during 1986. That value is a factor of 2 higher than the federal 24-h average PM_(10) concentration standard, and a factor of 6 higher than the State of California PM_(10) standard. More than 40% of the PM_(10) aerosol mass measured at Rubidoux during that peak day event consisted of aerosol nitrates plus ammonium ion. Reaction of gaseous nitric acid to form aerosol nitrates was a major contributor to the high PM_(10) concentrations observed in the Rubidoux area near Riverside, California

The Academic Senate and University Governance in Canada

This study examines the academic senate within the context of university governance in Canada. Data were obtained from a survey of university senate secretaries on senate structure, composition, and operation, and from a survey of senate members on their perceptions of the senate, their role as senate members, and the nature of their work. The study raises concerns over the effectiveness of the senate and suggests a need to review the senate and its role in contemporary university governance within the context of the current Canadian higher education environment.La présente étude examine le sénat académique dans le cadre de la gouvernance des établissements universitaires au Canada. Des données ont été obtenues à partir d'une enquête menée auprès de secrétaires de sénats universitaires sur la structure, la composition et le fonctionnement des sénats ainsi qu'à partir d'une enquête menée auprès de membres de sénats sur leurs perceptions du sénat, leur rôle en tant que membres de ce dernier et la nature de leur travail. Cette étude soulève des préoccupations sur l'efficacité du sénat et propose la nécessité de réexaminer celui-ci ainsi que le rôle qu'il joue dans la gouvernance des établissements universitaires contemporains, etce dans le contexte de l'environnement actuel de l'enseignement supérieur au Canada

Water Integration for Squamscott Exeter (WISE): Preliminary Integrated Plan, Final Technical Report

This document introduces the goals, background and primary elements of an Integrated Plan for the Lower Exeter and Squamscott River in the Great Bay estuary in southern New Hampshire. This Plan will support management of point (wastewater treatment plant) and nonpoint sources in the communities of Exeter, Stratham and Newfields. The Plan also identifies and quantifies the advantages of the use of green infrastructure as a critical tool for nitrogen management and describes how collaboration between those communities could form the basis for an integrated plan. The Plan will help communities meet new wastewater and proposed stormwater permit requirements. Critical next steps are need before this Plan will fulfill the 2018 Nitrogen Control Plan requirements for Exeter and proposed draft MS4 requirements for both Stratham and Exeter. These next steps include conducting a financial capability assessment, development of an implementation schedule and development of a detailed implementation plan. The collaborative process used to develop this Plan was designed to provide decision makers at the local, state and federal levels with the knowledge they need to trust the Plan’s findings and recommendations, and to enable discussions between stakeholders to continue the collaborative process. This Plan includes the following information to guide local response to new federal permit requirements for treating and discharging stormwater and wastewater: Sources of annual pollutant load quantified by type and community; Assessment and evaluation of different treatment control strategies for each type of pollutant load; Assessment and evaluation of nutrient control strategies designed to reduce specific types of pollutants; Evaluation of a range of point source controls at the wastewater treatment facility based on regulatory requirements; Costs associated with a range of potential control strategies to achieve reduction of nitrogen and other pollutants of concern; and A preliminary implementation schedule with milestones for target load reductions using specific practices for specific land uses at points in time; Recommendations on how to implement a tracking and accounting program to document implementation; Design tools such as BMP performance curves for crediting the use of structural practices to support nitrogen accounting requirements; and Next Steps for how to complete this Plan

Life’s hard and then you die: the end-of-life priorities of people experiencing homelessness in the UK

Background: People experiencing homelessness often die young and without adequate support. In the UK, they fail to access palliative care services and their end-of-life priorities remain poorly understood. Aims: To explore the end-of-life concerns, fears, preferences and priorities of a sample of people experiencing homelessness in the UK. Methods: This is an interpretive phenomenology. Data collected through semi-structured, audio-recorded, face-to-face interviews with 21 homeless participants in the UK were analysed iteratively using thematic analysis. Findings have been interpreted through the lens of Merleau-Ponty’s philosophy. Results: Eight themes are reported: spiritual concerns; practical concerns; fear of needing care; fear of being forgotten; preference for dying suddenly; preference for being somewhere comfortable where people know me; prioritising autonomy and self-determination; and prioritising authenticity. Conclusion: A strengths-based, trauma-informed, person-centred, collaborative ‘compassionate community’ approach to care is recommended for people experiencing homelessness at end of life