3,021 research outputs found

    The Problen of the Apparent Conflict Between Paul and James

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    The problem of the exposition of justification is not, however, the only point on which the Epistle of James and the works of Paul are said to vary. Other difficulties that have been cited include the apostles\u27 supposedly varying concepts of sin, their description of God, and the lack of emphasis regarding Christ in the epistle James wrote as compared to the Christ-centered exposition of doctrine penned by Paul. On these points, as we shall find in this thesis, the difference lies not so much in the words that are expressed by the apostles, but rather in the scope of the writings of Paul as compared with James. Differences of belief and differences in theology between the two are unjustly adduced from what is left unsaid

    Notas sobre la filogenia de los equidos y en especial del Hipparion

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    Doping dependence of heat transport in the iron-arsenide superconductor Ba(Fe1x_{1-x}Cox_x)2_2As2_2: from isotropic to strongly kk-dependent gap structure

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    The temperature and magnetic field dependence of the in-plane thermal conductivity κ\kappa of the iron-arsenide superconductor Ba(Fe1x_{1-x}Cox_x)2_2As2_2 was measured down to T50T \simeq 50 mK and up to H=15H = 15 T as a function of Co concentration xx in the range 0.048 x \leq x \leq 0.114. In zero magnetic field, a negligible residual linear term in κ/T\kappa/T as T0T \to 0 at all xx shows that there are no zero-energy quasiparticles and hence the superconducting gap has no nodes in the abab-plane anywhere in the phase diagram. However, the field dependence of κ\kappa reveals a systematic evolution of the superconducting gap with doping xx, from large everywhere on the Fermi surface in the underdoped regime, as evidenced by a flat κ(H)\kappa (H) at T0T \to 0, to strongly kk-dependent in the overdoped regime, where a small magnetic field can induce a large residual linear term, indicative of a deep minimum in the gap magnitude somewhere on the Fermi surface. This shows that the superconducting gap structure has a strongly kk-dependent amplitude around the Fermi surface only outside the antiferromagnetic/orthorhombic phase.Comment: version accepted for publication in Physical Review Letters; new title, minor revision, revised fig.1, and updated reference

    Analytical model for tracer dispersion in porous media

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    In this work, we present a novel analytical model for tracer dispersion in laminar flow through porous media. Based on a straightforward physical argument, it describes the generic behavior of dispersion over a wide range of Peclet numbers (exceeding 8 orders of magnitude). In particular, the model accurately captures the intermediate scaling behavior of longitudinal dispersion, obviating the need to subdivide the dispersional behavior into a number of disjunct regimes or using empirical power law expressions. The analysis also reveals the existence of a new material property, the critical Peclet number, which reflects the mesoscale geometric properties of the microscopic pore structure.Comment: 13 pages, 4 figure

    SYSBIONS: nested sampling for systems biology.

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    MOTIVATION: Model selection is a fundamental part of the scientific process in systems biology. Given a set of competing hypotheses, we routinely wish to choose the one that best explains the observed data. In the Bayesian framework, models are compared via Bayes factors (the ratio of evidences), where a model's evidence is the support given to the model by the data. A parallel interest is inferring the distribution of the parameters that define a model. Nested sampling is a method for the computation of a model's evidence and the generation of samples from the posterior parameter distribution. RESULTS: We present a C-based, GPU-accelerated implementation of nested sampling that is designed for biological applications. The algorithm follows a standard routine with optional extensions and additional features. We provide a number of methods for sampling from the prior subject to a likelihood constraint. AVAILABILITY AND IMPLEMENTATION: The software SYSBIONS is available from http://www.theosysbio.bio.ic.ac.uk/resources/sysbions/ CONTACT: [email protected], [email protected]

    A graph theoretical approach to data fusion.

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    The rapid development of high throughput experimental techniques has resulted in a growing diversity of genomic datasets being produced and requiring analysis. Therefore, it is increasingly being recognized that we can gain deeper understanding about underlying biology by combining the insights obtained from multiple, diverse datasets. Thus we propose a novel scalable computational approach to unsupervised data fusion. Our technique exploits network representations of the data to identify similarities among the datasets. We may work within the Bayesian formalism, using Bayesian nonparametric approaches to model each dataset; or (for fast, approximate, and massive scale data fusion) can naturally switch to more heuristic modeling techniques. An advantage of the proposed approach is that each dataset can initially be modeled independently (in parallel), before applying a fast post-processing step to perform data integration. This allows us to incorporate new experimental data in an online fashion, without having to rerun all of the analysis. We first demonstrate the applicability of our tool on artificial data, and then on examples from the literature, which include yeast cell cycle, breast cancer and sporadic inclusion body myositis datasets

    Topological sensitivity analysis for systems biology.

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    Mathematical models of natural systems are abstractions of much more complicated processes. Developing informative and realistic models of such systems typically involves suitable statistical inference methods, domain expertise, and a modicum of luck. Except for cases where physical principles provide sufficient guidance, it will also be generally possible to come up with a large number of potential models that are compatible with a given natural system and any finite amount of data generated from experiments on that system. Here we develop a computational framework to systematically evaluate potentially vast sets of candidate differential equation models in light of experimental and prior knowledge about biological systems. This topological sensitivity analysis enables us to evaluate quantitatively the dependence of model inferences and predictions on the assumed model structures. Failure to consider the impact of structural uncertainty introduces biases into the analysis and potentially gives rise to misleading conclusions
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