ENERGY POTENTIAL FROM AGRICULTURAL RESIDUES IN TEXAS

Resource /Energy Economics and Policy,

An Examination of the Doctrine of Death and the Afterlife from a Biblical and Historical Theology Perspective Compared to the Level of Sophistication among the Laity

Several key aspects of eschatology and their treatment appear to be under-explored in contemporary preaching. Within the context of individual eschatology, notions of death, the intermediate state, and the eternal state vary widely. A clearer understanding of these facets of the faith are necessary to fully understand the full measure of the work of Christ, the hope Christians have in Him, and the ability to convey these essentials to the lost. In this project, the writer will seek to discover and examine the key aspects of this doctrine and measure the level of sophistication among a sample of the laity. The measurement will be conducted via a confidential online survey of professing believers. At a practical level the goal of the project is that both pastors and laity would be edified on the central issues of the doctrine and that per its content pastors could utilize the data to craft sermons and lessons that take into consideration the identified weaknesses in knowledge as expressed by the participants

Ordovician Stratigraphy and the Physiography of Part of Southeastern Indiana

Indiana Geological Survey Guidebook 6This field trip guidebook discusses the stratigraphy and paleontology of the Ordovician rocks exposed in southeastern Indiana. Ordovician rocks in southern Indiana are exposed in a region that is stimulating to physiographers and Pleistocene geologist. Consequently, in addition to the stratigraphy and paleontology of the Ordovician bedrock, this conference directs attention to prominent physiographic features in this area, many of which owe their origin to Pleistocene glaciation, and to concepts regarding their development. Ordovician rocks in southern Indiana are paleontologically attractive because they are so richly fossiliferous. Well-preserved specimens maybe readily collected in weathered exposures and in the soft shales of the Cincinnatian (Upper Ordovician) series. Southeastern Indiana has not yielded mineral commodities as plentifully as other parts of the state. Nevertheless, two stops and several observation points along the route of the caravan draw attention to some of the industrial minerals found in this area. This conference is designed to present as coherent a view as time will permit of the geology of southeastern Indiana. The stops have been carefully selected to show features of stratigraphic, paleontologic, physiographic, or economic interest. Informal discussion among participants will contribute greatly to the success of the conference.Department of Geology, Indiana University; Indiana Geological Survey; Indiana Department of Conservatio

Ordovician Stratigraphy, and the Physiography of Part of Southeastern Indiana

Within recent years field conferences sponsored by the Geological Survey, Indiana Department of Conservation, and the Department of Geology, Indiana University, have reviewed outstanding exposures and of parts of the Silurian, Devonian, Mississippian, and Pennsylvanian systems in southern Indiana. This conference is concerned, in part, with the stratigraphy and paleontology of the Ordovician rocks exposed in southeastern Indiana

Does the social context of early alcohol use affect risky drinking in adolescents? Prospective cohort study

BACKGROUND: There are limited longitudinal data on the associations between different social contexts of alcohol use and risky adolescent drinking. METHODS: Australian prospective longitudinal cohort of 1943 adolescents with 6 assessment waves at ages 14-17 years. Drinkers were asked where and how frequently they drank. Contexts were: at home with family, at home alone, at a party with friends, in a park/car, or at a bar/nightclub. The outcomes were prevalence and incidence of risky drinking (≥5 standard drinks (10g alcohol) on a day, past week) and very risky drinking (>20 standard drinks for males and >11 for females) in early (waves 1-2) and late (waves 3-6) adolescence. RESULTS: Forty-four percent (95 % CI: 41-46 %) reported past-week risky drinking on at least one wave during adolescence (waves 1-6). Drinking at a party was the most common repeated drinking context in early adolescence (28 %, 95 % CI 26-30 %); 15 % reported drinking repeatedly (3+ times) with their family in early adolescence (95 % CI: 14-17 %). For all contexts (including drinking with family), drinking 3+ times in a given context was associated with increased the risk of risky drinking in later adolescence. These effects remained apparent after adjustment for potential confounders (e.g. for drinking with family, adjusted RR 1.9; 95 % CI: 1.5-2.4). Similar patterns were observed for very risky drinking. CONCLUSIONS: Our results suggest that consumption with family does not protect against risky drinking. Furthermore, parents who wish to minimise high risk drinking by their adolescent children might also limit their children\u27s opportunities to consume alcohol in unsupervised settings

Familial alcohol supply, adolescent drinking and early alcohol onset in 45 low and middle income countries

This study estimated the extent of familial alcohol supply in 45 low and middle income countries (LMIC), and examined the country-level effects of familial alcohol supply on adolescents' alcohol use. We used data from 45 LMICs that participated in the Global School-Based Student Health Survey (GSHS) between 2003 and 2013 (n = 139,840). The weighted prevalence of familial alcohol supply in each country was estimated. Multilevel binary and ordinal logistic regression analyses were used to examine the country-level effect of familial alcohol supply on early onset of alcohol use (first alcohol before 12), past 30-day alcohol use, lifetime drunkenness and alcohol-related social problems. There were large variations between LMICs in the prevalence of familial alcohol supply and pattern of adolescent alcohol use. The prevalence of familial supply ranged from 0.1% in Tajikistan to 23.8% in St Lucia. It was estimated that a one percentage change in prevalence of familial alcohol supply was associated with 10%, 12% and 12% change in the odds of lifetime drunkenness (OR = 1.10, 95% CI = [1.04, 1.16]), early onset of alcohol use (OR = 1.12, 95% CI = [1.07, 1.08]) and more frequent drinking in the past month (OR = 1.12, 95% CI = [1.04, 1.20]). There were large variations in the prevalence of familial alcohol supply and adolescent alcohol use among LMICs. Adolescents in countries with higher prevalence of familial alcohol supply were more likely to start using alcohol at an earlier age, to have used alcohol in the past 30 days and experience intoxication

Inactivation of PI(3)K p110δ breaks regulatory T-cell-mediated immune tolerance to cancer.

Inhibitors against the p110δ isoform of phosphoinositide-3-OH kinase (PI(3)K) have shown remarkable therapeutic efficacy in some human leukaemias. As p110δ is primarily expressed in leukocytes, drugs against p110δ have not been considered for the treatment of solid tumours. Here we report that p110δ inactivation in mice protects against a broad range of cancers, including non-haematological solid tumours. We demonstrate that p110δ inactivation in regulatory T cells unleashes CD8(+) cytotoxic T cells and induces tumour regression. Thus, p110δ inhibitors can break tumour-induced immune tolerance and should be considered for wider use in oncology

National mitigation potential from natural climate solutions in the tropics.

Better land stewardship is needed to achieve the Paris Agreement's temperature goal, particularly in the tropics, where greenhouse gas emissions from the destruction of ecosystems are largest, and where the potential for additional land carbon storage is greatest. As countries enhance their nationally determined contributions (NDCs) to the Paris Agreement, confusion persists about the potential contribution of better land stewardship to meeting the Agreement's goal to hold global warming below 2°C. We assess cost-effective tropical country-level potential of natural climate solutions (NCS)-protection, improved management and restoration of ecosystems-to deliver climate mitigation linked with sustainable development goals (SDGs). We identify groups of countries with distinctive NCS portfolios, and we explore factors (governance, financial capacity) influencing the feasibility of unlocking national NCS potential. Cost-effective tropical NCS offers globally significant climate mitigation in the coming decades (6.56 Pg CO2e yr-1 at less than 100 US$ per Mg CO2e). In half of the tropical countries, cost-effective NCS could mitigate over half of national emissions. In more than a quarter of tropical countries, cost-effective NCS potential is greater than national emissions. We identify countries where, with international financing and political will, NCS can cost-effectively deliver the majority of enhanced NDCs while transforming national economies and contributing to SDGs. This article is part of the theme issue 'Climate change and ecosystems: threats, opportunities and solutions'

Novel Cell- and Tissue-Based Assays for Detecting Misfolded and Aggregated Protein Accumulation Within Aggresomes and Inclusion Bodies

Aggresomes and related inclusion bodies appear to serve as storage depots for misfolded and aggregated proteins within cells, which can potentially be degraded by the autophagy pathway. A homogenous fluorescence-based assay was devised to detect aggregated proteins inside aggresomes and inclusion bodies within an authentic cellular context. The assay employs a novel red fluorescent molecular rotor dye, which is essentially nonfluorescent until it binds to structural features associated with the aggregated protein cargo. Aggresomes and related structures were generated within cultured cells using various potent, cell permeable, proteasome inhibitors: MG-132, lactacystin, epoxomicin and bortezomib, and then selectively detected with the fluorescent probe. Employing the probe in combination with various fluorescein-labeled primary antibodies facilitated co-localization of key components of the autophagy system (ubiquitin, p62, and LC3) with aggregated protein cargo by fluorescence microscopy. Furthermore, cytoplasmic aggregates were highlighted in SK-N-SH human neuroblastoma cells incubated with exogenously supplied amyloid beta peptide 1–42. SMER28, a small molecule modulator of autophagy acting via an mTOR-independent mechanism, prevented the accumulation of amyloid beta peptide within these cells. The described assay allows assessment of the effects of protein aggregation directly in cells, without resorting to the use of non-physiological protein mutations or genetically engineered cell lines. With minor modification, the assay was also adapted to the analysis of frozen or formalin-fixed, paraffin-embedded tissue sections, with demonstration of co-localization of aggregated cargo with β-amyloid and tau proteins in brain tissue sections from Alzheimer’s disease patients