14 research outputs found
Nasal ala pressure sores following head and neck reconstructive surgery: A retrospective analysis from a tertiary cancer hospital
Role of fluorodeoxyglucose positron emission tomography-Computed tomography in thyroid malignancy
The role of FDG PET CT in thyroid malignancy is not clearly established. Malignancy of the thyroid remains poses issues very different from the squamous carcinomas of the upper aerodigestive tract where PET-CT is usually used. Though this is the most common endocrine malignancy, many a times it is difficult to diagnose malignancy in thyroid nodules. The biology of well differentiated thyroid cancer, medullary carcinoma, poorly differentiated carcinoma and anaplastic carcinoma varies significantly and management strategies differ dramatically. FDG PET can be used as a wonderful tool in thyroid malignancy for selected indications
Infratemporal fossa clearance for oral squamous cancer: Is it time to shift the paradigm.
Overexpression of CD73 is associated with recurrence and poor prognosis of gingivobuccal oral cancer as revealed by transcriptome and deep immune profiling of paired tumor and margin tissues
Abstract Background For various cancers, differences in response to treatment and subsequent survival period have been reported to be associated with variation in immune contextures. Aim We sought to identify whether such association exists in respect of gingivobuccal oral cancer. Materials and methods We performed deep immune profiling of tumor and margin tissues collected from 46 treatment naĂŻve, Human Papillomavirus (HPV) negative, patients. Each patient was followed for 24âmonths and prognosis (recurrence/death) noted. Key findings were validated by comparing with TCGAâHNSC cohort data. Results About 28% of patients showed poor postâtreatment prognosis. These patients exhibited a high probability of recurrence even within 1âyear and death within 2âyears. There was restricted immune cell infiltration in tumor, but not in margin, among these patients. Reduced expression of eight immuneârelated genes (IRGs) (NT5E, THRA, RBP1, TLR4, ITGA6, BMPR1B, ITGAV, SSTR1) in tumor strongly predicted better quality of prognosis, both in our patient cohort and in TCGAâHNSC cohort. Tumors of patients with better prognosis were associated with (a) lower CD73+ cells with concomitant lower expression level of NT5E/CD73, (b) higher proportions of CD4+ and CD8+ T cells, B cells, NK cells, M1 macrophages, (c) higher %Granzyme+ cells, (d) higher TCR and BCR repertoire diversities. CD73 expression in tumor was associated with low CD8+ and CD4+ T cells, low immune repertoire diversity, and advanced cancer stage. Discussion and conclusion High infiltration of antiâtumor immune cells in both tumors and margins results in good prognosis, while in patients with minimal infiltration in tumors in spite of high infiltration in margins results in poor prognosis. Targeted CD73 immuneâcheckpoint inhibition may improve clinical outcome