2 research outputs found
First in vivo MRI study on theranostic dendrimersomes
Amphiphilic Janus-dendrimers are able to self-assemble into nanosized vesicles named dendrimersomes.We recently
synthesized the 3,5-C12-EG-(OH)4 dendrimer that generates dendrimersomes with very promising safety
and stability profiles, that can be loaded with different contrast agents for in vivo imaging. In this contribution,
nanovesicles were loaded with both the Magnetic Resonance Imaging (MRI) reporter GdDOTAGA(C18)2 and
the glucocorticoid drug Prednisolone Phosphate (PLP), in order to test their effective potential as theranostic
nanocarriers on murine melanoma tumour models. The incorporation of GdDOTAGA(C18)2 into the membrane
resulted in dendrimersomes with a high longitudinal relaxivity (r1 = 39.1 mM−1 s−1, at 310 K and 40 MHz)
so that, after intravenous administration, T1-weighted MRI showed a consistent contrast enhancement in the tumour
area. Furthermore, the nanovesicles encapsulated PLP with good efficiency and displayed anti-tumour activity
both in vitro and in vivo, thus enabling their practical use for biomedical theranostic applications