Metal–Ligand Binding Affinity vs Reactivity: Qualitative Studies in Rh(I)-Catalyzed Asymmetric Ring-Opening Reactions

Rh(I)-catalyzed asymmetric ring opening (ARO) of oxabenzonorbornadiene is used as a model system to qualitatively study reactions involving multiple metal–ligand interactions. The key feature of this approach is the use of product <i>ee</i> as an indicator to quickly gain important information such as the relative ligand binding affinity and relative reactivity of catalysts

One-Pot Synthesis of Chiral Dihydrobenzofuran Framework via Rh/Pd Catalysis

A one-pot synthesis of the chiral dihydrobenzofuran framework is described. The method utilizes Rh-catalyzed asymmetric ring opening (ARO) and Pd-catalyzed C–O coupling to furnish the product in excellent enantioselectivity without isolation of intermediates. Systematic metal–ligand studies were carried out to investigate the compatibility of each catalytic system using product enantiopurity as an indicator

One-Pot Synthesis of Chiral Dihydrobenzofuran Framework via Rh/Pd Catalysis

A one-pot synthesis of the chiral dihydrobenzofuran framework is described. The method utilizes Rh-catalyzed asymmetric ring opening (ARO) and Pd-catalyzed C–O coupling to furnish the product in excellent enantioselectivity without isolation of intermediates. Systematic metal–ligand studies were carried out to investigate the compatibility of each catalytic system using product enantiopurity as an indicator