Metal–Ligand Binding Affinity vs Reactivity: Qualitative Studies in Rh(I)-Catalyzed Asymmetric Ring-Opening Reactions

Abstract

Rh(I)-catalyzed asymmetric ring opening (ARO) of oxabenzonorbornadiene is used as a model system to qualitatively study reactions involving multiple metal–ligand interactions. The key feature of this approach is the use of product <i>ee</i> as an indicator to quickly gain important information such as the relative ligand binding affinity and relative reactivity of catalysts