Occult Nosocomial Infections

Even with a good surveillance program, nosocomial infections may be not recognized because of several reasons: absence of symptoms or prolonged incubation period (eg, viral bloodborne infections, tuberculosis); problems with the microbiological diagnosis, because adequate specimens may be difficult to obtain or special methods should be used (eg, fungal infections, virus, new agents); shorter hospital stays (eg, surgical-site infections); difficulty in distinguishing between nosocomial and community-acquired infections (eg, influenza); and failure to detect clinically relevant colonization (eg, multiresistant microorganisms). Because of the important potential consequences of occult nosocomial infections, specific surveillance programs should be designed to address these problem

Impact of the Correlation between Flow Rates and Durations on the Large-Scale Properties of Aggregate Network Traffic

Since the discovery of long-range dependence in network traffic in 1993, many models have appeared to reproduce this property, based on heavy-tailed distributions of some flow-scale properties of the traffic. However, none of these models consider the correlation existing between flow rates and flow durations. In this work, we extend previously proposed models to include this correlation. Based on a planar Poisson process setting, which describes the flow-scale traffic structure, we analytically compute the auto-covariance function of the aggregate traffic's bandwidth and show that it exhibits long-range dependence with a different Hurst parameter. In uncorrelated case, the model that we propose is consistent with existing models, and predict the same Hurst parameter. We also prove that pseudo long-range dependence with a different index can arise from highly variable flow rates. The pertinence of our model choices is validated on real web traffic traces

Rhazinilam-leuconolam family of natural products: a half century of total synthesis

Covering: 1972 to 2021The rhazinilam family of natural products exhibits a main structure with a stereogenic quaternary carbon and a tetrahydroindolizine core imbedded within a 9-membered macrocycle, imposing axial chirality. This unique architecture combined with their taxol-like antimitotic activities have attracted various attention, especially from synthetic chemists, notably in the past decade. The present review describes the known total and formal syntheses of the members of the rhazinilam family (rhazinilam, rhazinal, leuconolam and kopsiyunnanines), according to the strategy developed

Total Synthesis of Rhazinilam through Gold-Catalyzed Cycloisomerization–Sulfonyl Migration and Palladium-Catalyzed Suzuki–Miyaura Coupling of Pyrrolyl Sulfonates

International audienceWe report the first general conditions for the challenging Suzuki-Miyaura reaction with pyrrole-related sulfonate coupling partners (24 examples, 60-97%). Bis(dichloro)bis(2-dicyclohexylphosphino-2′,4′,6′-triiso-propylbiphenyl) palladium(II) precatalyst ensures the high efficiency of the reaction. The total synthesis of rhazinilam, a monoterpenoid indole alkaloid, highlights such cross-coupling as well as the simple preparation of pyrrolyl sulfonates by N-toO 1,5-sulfonyl migration catalyzed by gold(I) (15 examples, 54-93%)

Molecular Epidemiology of Methicillin-Resistant Staphyloccocus aureus at a Low-Incidence Hospital over a 4-Year Period

Abstract Objective: To study the epidemiology of methicillin-resistant Staphylococcus aureus (MRSA) over a prolonged period of time with the aid of a molecular typing method (ribotyping). Setting: A 1,000-bed tertiary university medical center. Patients and Methods: Defined epidemiological data were recorded for all patients culture-positive for MRSA between 1989 and 1992. Ribotyping of MRSA strains was performed using three restriction enzymes: EcoRv, HindHI, and KpnI. Results: From 1989 to 1992, MRSA was isolated from clinical specimens in 98 patients and from surveillance cultures in 27 patients. Among the 122 isolates available for typing, 26 different ribotypes were identified. In 20% of the cases, MRSA was community-acquired, and a third of these patients never had been hospitalized previously. Nine ribotypes were responsible for more than one case (2 to 64 patients); 17 appeared only once. Epidemiological data correlated with ribotyping results revealed 14 epidemiologic clusters involving six different ribotypes, whereas only three outbreaks were suspected initially. The median follow-up after the last isolation of a given ribotype was 14 months (range, 1 to 42) for clusters and 25 months (range, 1 to 46) for ribotypes that appeared only once. During clusters, only 16% of the cases occurred after the implementation of control measures in the ward (breakthrough cases). Conclusions: The high diversity of MRSA strains observed over 4 years suggested that new strains were introduced continuously in our hospital. Furthermore, that 17 ribotypes were isolated only once, that breakthrough cases represented only 16% of the cases in clusters, and that the follow-up duration after the last isolation of a given ribotype was more than 14 months suggest that infection control measures were effective in limiting the nosocomial spread of MRSA over a prolonged period of tim

Voyage en Méditerranée. La mosaïque aux îles

catalogue de l'exposition sur la mosaïque aux îles d'Ammaedara (Haïdra, Tunisie) du 15 septembre au 18 novembre 2018, Musée départemental Arles antiqu

Document d'aide au déploiement d'IPv6 sur Grid5000

Ce document présente succinctement les motivations pour l'utilisation d'IPv6 dans les grilles. Une analyse des opérations nécessaires pour son déploiement dans la plateforme Grid5000 est ensuite présentée et détaillée

Nouvelle intervention sur la mosaïque du sanctuaire de Mar Gabriel (Turquie orientale)

International audienc