Next-Generation Media: The Global Shift

For over a decade the Aspen Institute Communications and Society Program has convened its CEO-level Forum on Communications and Society (FOCAS) to address specific issues relating to the impact of communications media on societal institutions and values. These small, invitation-only roundtables have addressed educational, democratic, and international issues with the aim of making recommendations to policy-makers, businesses and other institutions to improve our society through policies and actions in the information and communications sectors.In the summer of 2006 the forum took a different turn. It is clear there is a revolution affecting every media business, every consumer or user of media, and every institution affected by media. In a word, everyone. FOCAS sought to define the paradigm changes underway in the media, and to identify some of the significant repercussions of those changes on society."Next Generation Media" was a three-day meeting among leaders from new media (e.g., Google, craigslist, and Second Life) and mainstream media (e.g., The New York Times and Time), from business, government, academia and the non-profit sector, all seeking a broad picture of where the digital revolution is taking us.This report of the meeting, concisely and deftly written by Richard Adler, a longtime consultant in the field, weaves insights and anecdotes from the roundtable into a coherent document supplemented with his own research and data to form an accessible, coherent treatment of this very topical subject.The specific goals of the 2006 forum were to examine the profound changes ahead for the media industries, advertisers, consumers and users in the new attention economy; to understand how the development and delivery of content are creating new business models for commercial and non-commercial media; and to assess the impact of these developments on global relations, citizenship and leadership.The report thus examines the growth of the Internet and its effect on a rapidly changing topic: the impact of new media on politics, business, society, culture, and governments the world over. The report also sheds light on how traditional media will need to adapt to face the competition of the next generation media.Beginning, as the Forum did, with data from Jeff Cole's Center for the Digital Future at the University of Southern California, Adler documents the increasing popularity of the Internet for information, entertainment and communication. Users are increasingly generating and contributing content to the web and connecting to social networks. They are posting comments, uploading pictures, sharing videos, blogging and vlogging, chatting through instant messages or voice over Internet (VoIP), or emailing friends, business colleagues, neighbors and even strangers. As Cole observes, "Traditional media informed people but didn't empower them." New media do.The report describes three of the Internet's most successful ventures -- Wikipedia, Second Life, and craigslist. Wikipedia is a prime example of how an Internet platform allows its users to generate content and consume it. As a result of "wiki" software technology anyone can contribute or edit existing information free of cost. Second Life, a virtual world, sells virtual real estate where subscribers, in avatar form, can conduct conversations, go to lectures, even create a business. Craigslist, a predominantly free online classified site with listings in every major city in the United States, has become so popular that it is posing a significant threat to newspapers as it competes with their classified ad revenues.As a result of these and other new media phenomena, not the least being Google and Yahoo, print publications are wrestling with new business models that could entail fundamentally restructuring the way they operate. For instance, reporters are now expected to report a story on multiple media platforms and discuss them online with readers. Newspaper publisher Gannett is exploring the incorporation of usergenerated news or "citizen-journalism" into its news pages.In an era of abundant choices marketers have an even greater challenge to figure out how best to appeal to consumers. The report explores how marketers, e.g., of Hollywood movies or pomegranate juice, are moving from traditional or mainstream media to viral and other marketing techniques.For much of the world, the mobile phone rather than the computer is the most important communications device. Users depend on their phones to send and receive messages, pictures, and download information rather than just talk. In developing countries mobile phones are having an exceptional impact, penetrating regions which are not being serviced by land lines. Thus we are seeing new uses daily for this increased connectivity, from reporting election results in emerging democracies to opposing authoritarian governments in order to bring about new democracies.Meanwhile, the report discusses the need for the United States to develop a new form of public diplomacy rather than the traditional top-down approach to communicating to foreign citizens. This topic has been a recurring theme at FOCAS conferences the past few years, this year calling for more citizen diplomacy -- that is, more person-toperson contact across borders through uses of the new media. Indeed, Peter Hirshberg suggested that American leaders should listen more to the outside world to effectively manage what he called "Brand America."Finally, after acknowledging the detrimental effects that new technologies can bring about, the report discusses what role those technologies could play in expanding freedom and opportunity for the next generation. As a conclusion, FOCAS co-chair Marc Nathanson proposed adding a ninth goal to the United Nations Millennium Goals, namely, "to provide access to appropriate new technologies.

Characteristics of Usual Physical Therapy Post-Total Knee Replacement and their Associations with Functional Outcomes

OBJECTIVE: Although total knee replacement surgery (TKR) is highly prevalent and generally successful, functional outcomes post-TKR vary widely. Most patients receive some physical therapy (PT) following TKR, but PT practice is variable and associations between specific content and dosage of PT interventions and functional outcomes are unknown. Research has identified exercise interventions associated with better outcomes but studies have not assessed whether such evidence has been translated into clinical practice. We characterized the content, dosage and progression of usual post-acute PT services following TKR, and examined associations of specific details of post-acute PT with patients\u27 6-month functional outcomes. METHODS: Post-acute PT data were collected from patients undergoing primary unilateral TKR and participating in a clinical trial of a phone-based coaching intervention. PT records from the terminal episode of care were reviewed and utilization and exercise content data were extracted. Descriptive statistics and linear regression models characterized PT treatment factors and identified associations with 6-month outcomes. RESULTS: We analyzed 112 records from 30 PT sites. Content and dosage of specific exercises and incidence of progression varied widely. Open chain exercises were utilized more frequently than closed chain (median and interquartile range (21(4,49) vs 13(4,28.5)). Median (interquartile range) occurrence of progression of closed and open chain exercise was 0 (0,2) and 1 (0,3) respectively. Shorter timed stair climb was associated with greater total number of PT interventions and use and progression of closed chain exercises. DISCUSSION: Data suggest that evidence-based interventions are under-utilized and dosage may be insufficient to obtain optimal outcomes

Guidelines for Physical Activity During Pregnancy: Comparisons From Around the World

Introduction. Women attain numerous benefits from physical activity during pregnancy. However, because of physical changes that occur during pregnancy, special precautions are also needed. This review summarizes current guidelines for physical activity among pregnant women worldwide. Methods. We searched PubMed (MedLINE) for country-specific governmental and clinical guidelines on physical activity during pregnancy through the year 2012. We cross-referenced with articles referring to guidelines, with only the most recent included. An abstraction form was used to extract key details and summarize. Results. In total, 11 guidelines were identified from 9 countries (Australia, Canada, Denmark, France, Japan, Norway, Spain, United Kingdom, United States). Most guidelines supported moderate-intensity physical activity during pregnancy (10/11) and indicated specific frequency (9/11) and duration/time (9/11) recommendations. Most guidelines provided advice on initiating an exercise program during pregnancy (10/11). Six guidelines included absolute and relative contraindications to exercise. All guidelines generally ruled-out sports with risks of falls, trauma, or collisions. Six guidelines included indications for stopping exercise during pregnancy. Conclusion. This review contrasted pregnancy-related physical activity guidelines from around the world, and can help inform new guidelines as they are created or updated and facilitate the development of a worldwide guideline. © 2013 The Author(s)

Continence for Women: Evaluation of AWHONN's Third Research Utilization Project

To develop an evidence-based protocol for initial evaluation and treatment of urinary incontinence and to design procedures that would facilitate the protocol's implementation into clinical practice. Design : Descriptive report of the Association of Women's Health, Obstetric and Neonatal Nurses (AWHONN) Continence for Women Project. Setting : Twenty-one public, private, and other women's health sites. Participants : Women in ambulatory care settings ( N = 1,474) provided demographic statistics. Methods : The protocol was developed, sites were selected, site coordinator training was provided, data collection was facilitated by project-specific tele-forms, and the overall process was evaluated by the science team. Main Outcome Measures : Site representation, patient representation, site coordinator feedback on the training program, and site coordinator experience during project implementation. Results : The process yielded a representative mix of site and patient diversity appropriate for testing of the protocol. Site coordinators felt well-prepared to implement the protocol and experienced increased professional satisfaction because of therapeutic benefits achieved for patients and positive collaboration with physicians. Conclusions : The Continence for Women Project demonstrated the potential for developing and testing evidence-based protocols for clinical practice when the resources of an organization such as AWHONN and the research community are combined.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/74617/1/j.1552-6909.2000.tb02751.x.pd

An optimised monophasic faecal extraction method for LC-MS analysis and its application in gastrointestinal disease

Liquid chromatography coupled with mass spectrometry (LC-MS) metabolomic approaches are widely used to investigate underlying pathogenesis of gastrointestinal disease and mechanism of action of treatments. However, there is an unmet requirement to assess faecal metabolite extraction methods for large-scale metabolomics studies. Current methods often rely on biphasic extractions using harmful halogenated solvents, making automation and large-scale studies challenging. The present study reports an optimised monophasic faecal extraction protocol that is suitable for untargeted and targeted LC-MS analyses. The impact of several experimental parameters, including sample weight, extraction solvent, cellular disruption method, and sample-to-solvent ratio, were investigated. It is suggested that a 50 mg freeze-dried faecal sample should be used in a methanol extraction (1:20) using bead beating as the means of cell disruption. This is revealed by a significant increase in number of metabolites detected, improved signal intensity, and wide metabolic coverage given by each of the above extraction parameters. Finally, we addressed the applicability of the method on faecal samples from patients with Crohn’s disease (CD) and coeliac disease (CoD), two distinct chronic gastrointestinal diseases involving metabolic perturbations. Untargeted and targeted metabolomic analysis demonstrated the ability of the developed method to detect and stratify metabolites extracted from patient groups and healthy controls (HC), highlighting characteristic changes in the faecal metabolome according to disease. The method developed is, therefore, suitable for the analysis of patients with gastrointestinal disease and can be used to detect and distinguish differences in the metabolomes of CD, CoD, and HC

Recommendations for Effective Integration of Ethics and Responsible Conduct of Research (E/RCR) Education into Course-Based Undergraduate Research Experiences: A Meeting Report.

Advancement of the scientific enterprise relies on individuals conducting research in an ethical and responsible manner. Educating emergent scholars in the principles of ethics/responsible conduct of research (E/RCR) is therefore critical to ensuring such advancement. The recent impetus to include authentic research opportunities as part of the undergraduate curriculum, via course-based undergraduate research experiences (CUREs), has been shown to increase cognitive and noncognitive student outcomes. Because of these important benefits, CUREs are becoming more common and often constitute the first research experience for many students. However, despite the importance of E/RCR in the research process, we know of few efforts to incorporate E/RCR education into CUREs. The Ethics Network for Course-based Opportunities in Undergraduate Research (ENCOUR) was created to address this concern and promote the integration of E/RCR within CUREs in the biological sciences and related disciplines. During the inaugural ENCOUR meeting, a four-pronged approach was used to develop guidelines for the effective integration of E/RCR in CUREs. This approach included: 1) defining appropriate student learning objectives; 2) identifying relevant curriculum; 3) identifying relevant assessments; and 4) defining key aspects of professional development for CURE facilitators. Meeting outcomes, including the aforementioned E/RCR guidelines, are described herein

Genome-wide expression analyses of Campylobacter jejuni NCTC11168 reveals coordinate regulation of motility and virulence by flhA.

We examined two variants of the genome-sequenced strain, Campylobacter jejuni NCTC11168, which show marked differences in their virulence properties including colonization of poultry, invasion of Caco-2 cells, and motility. Transcript profiles obtained from whole genome DNA microarrays and proteome analyses demonstrated that these differences are reflected in late flagellar structural components and in virulence factors including those involved in flagellar glycosylation and cytolethal distending toxin production. We identified putative sigma(28) and sigma(54) promoters for many of the affected genes and found that greater differences in expression were observed for sigma(28)-controlled genes. Inactivation of the gene encoding sigma(28), fliA, resulted in an unexpected increase in transcripts with sigma(54) promoters, as well as decreased transcription of sigma(28)-regulated genes. This was unlike the transcription profile observed for the attenuated C. jejuni variant, suggesting that the reduced virulence of this organism was not entirely due to impaired function of sigma(28). However, inactivation of flhA, an important component of the flagellar export apparatus, resulted in expression patterns similar to that of the attenuated variant. These findings indicate that the flagellar regulatory system plays an important role in campylobacter pathogenesis and that flhA is a key element involved in the coordinate regulation of late flagellar genes and of virulence factors in C. jejuni