Application of phosphorous trichloride in attempted bis-indolisation of cyclohexanediones and dimedone

1104-110

Threat to Ambient Air Quality Due to Poor Municipal Solid Waste Management: A Case Study in and around Vuasuni Dumping Site, Bhubaneswar, Odisha , India.

The objective of this study is to assess the state of air quality near municipal solid waste dumping site of the smart city Bhubaneswar, Odisha,India. Air Quality Index (AQI) in the study area has been calculated by measuring parameters like particulate matter (PM10, PM2.5), sulphur dioxide (SO2), oxides of nitrogen (NOx) and carbonmonoxide (CO). Air status from AQI study depicts moderately pollution at dumping site (AQI=51.9). Corelation study shows a strongly direct relation among AQI and PM10 (r=0.964). Regression study reflects PM10 is good at predicting AQI (R2=0.93065, p<0.0001). Multiple linear regression (MLR) study predicts AQI with very less error(rss=0.0003) where PM10, PM2.5, SO2, NOx and CO are independent variables. This study also identifies potential sources of pollution and the extent of air pollution. In addition, management strategies have been proposed to minimize the effects of pollutants. Key words: AQI, Air Pollution, PM10, MLR, Wind rose DOI: 10.7176/JEES/9-2-02

Benzopyrans: Part 39–2-Amino-3- iminomethyl-l-benzopyran-4-ones do not function as heterodienes

387- 39

Two new abnormal by-products of attempted Fischer-type bis-indolisation of cyclohexane-1,3-dione and dimedone

387-389<span style="font-size:13.5pt;mso-bidi-font-size:8.5pt; font-family:" times="" new="" roman";mso-fareast-font-family:"times="" roman";="" mso-ansi-language:en-us;mso-fareast-language:en-us;mso-bidi-language:ar-sa"="">An attempt to bring about the bis-indolisation of cyclohexane- 1,3-dione and dimedone separately by treatment with phenylhydrazine (two equiv.) in dry benzene in the presence of stoichiometric amounts (two equiv.) of phospho-rous trichloride furnishes, besides the corresponding bis-(phenylhydrazones), the respective 2-oxo-bis(phenylhydra-zones) as new by-products which have been identified by spectral analyses. A mechanism for the formation of the latter <span style="font-size:11.5pt;mso-bidi-font-size:6.5pt;font-family:HiddenHorzOCR; mso-hansi-font-family:" times="" new="" roman";mso-bidi-font-family:hiddenhorzocr;="" mso-ansi-language:en-us;mso-fareast-language:en-us;mso-bidi-language:ar-sa"="">has been proposed.</span

Regioselective Synthesis of Chiral Six- and Seven-Membered N-Heterocycles from N-AIIyl Carbohydrate Nitrones: Tuning of Regioselectivity by N-Substitution

The intramoleodar cydoaddition of N-allyl carbohydrate nitrones leads to enantiomefically pure six- and seven-membered nitrogen heterocydes and the regioselectivity of the cycloaddition was controlled by changing the substituent on the nitrogea atom of the N-allyl moiety. © 1999 Elsevier Science Ltd. All rights reserve

Evaluation of the Antimicrobial Activity of Some Medicinal Plants against Enteric Bacteria with Particular Reference to Multi-Drug Resistant Vibrio cholerae

Purpose: To evaluate the anti-enterobacterial potential of nine ethnobotanically selected plants traditionally used in different parts of India for the treatment of gastrointestinal disorders such as cholera, diarrhea or dysentery. Methods: The methanol extracts of these plants were screened for antibacterial activity against 11 strains of enteropathogenic bacteria, including multi-drug resistant Vibrio cholerae (serotypes O1, O139, and non-O1, non-O139), using broth microdilution method. Ampicillin was used as a positive reference standard to determine the sensitivity of the strains. Phytochemical screening was carried out for phenolics and flavonoids. Results: All of these plants had bactericidal activity against at least one of the test microorganisms with minimum inhibitory concentration (MIC) ranging from 0.125 to 32 mg/ml and minimum bactericidal concentration (MBC) ranging from 0.25 to 32 mg/ml. Among these, Terminalia chebula> Retz. (Combretaceae) and Syzygium cumini (L.) Skeels (Myrtaceae) showed the most promising broad spectrum antibacterial properties, inhibiting all of the strains tested, especially Vibrio cholerae, Aeromonas hydrophila and Bacillus subtilis, with MBC ranging from 0.25 to 4 mg/ml. Phenolics and flavonoids were found to be present in the extracts. Conclusion: The findings provide support for the use of this plant in traditional medicine for treatment of diarrheoa, especially cholera

Microwave assisted convenient and facile regeneration of carbonyl compounds from semicarbazones, phenylhydrazones and tosylhydrazones using phosphoric acid in solvent-free conditions

537-539Microwave irradiation of semicarbazones, phenylhydrazones and tosylhydrazones of carbonyl compounds with phosphoric acid under solvent-free conditions provides a fast, efficient and simple method for regeneration of carbonyls in excellent yields

Facile acid-catalyzed condensation of ninhydrin with enols and aromatic compounds and microwave enhanced condensation of ninhydrin with hydroxy aromatic systems in solid state

604-611Di-and trihydroxybenzenes, 2,6-dihydroxyacetophcnone, α- and β-naphthols and also 3- and 4-hydroxycoumarins and various enols smoothly condense with ninhydrin in HOAc medium giving 2-substituted 1,3-dioxoindanes. Monoarylated products were also obtained upon microwave irradiation of the reactants adsorbed on silica gel. Reactions with corresponding methyl ethers are sluggish but are accelerated in the presence of conc. H2SO4 to 2,2-di substituted 1,3-dioxoindane stage. Under latter conditions monoarylated products are also further arylated paving the way for mixed 2,2-diaryl-l,3-dioxoindanes. Generally, ninhydrin adducts from phenols, naphthols and acyclic enols remain in intramolecular hemiketal form. AM1 computed heats of formation in some representative cases also favours such intramolecular hemiketal formation. A series of spirolactones have been generated through proper designing and synthesis of mono-arylated ninhydrin adducts

Evaluation of the Antimicrobial Activity of Some Medicinal Plants against Enteric Bacteria with Particular Reference to Multi-Drug Resistant Vibrio cholerae

Purpose: To evaluate the anti-enterobacterial potential of nine ethnobotanically selected plants traditionally used in different parts of India for the treatment of gastrointestinal disorders such as cholera, diarrhea or dysentery. Methods: The methanol extracts of these plants were screened for antibacterial activity against 11 strains of enteropathogenic bacteria, including multi-drug resistant Vibrio cholerae (serotypes O1, O139, and non-O1, non-O139), using broth microdilution method. Ampicillin was used as a positive reference standard to determine the sensitivity of the strains. Phytochemical screening was carried out for phenolics and flavonoids. Results: All of these plants had bactericidal activity against at least one of the test microorganisms with minimum inhibitory concentration (MIC) ranging from 0.125 to 32 mg/ml and minimum bactericidal concentration (MBC) ranging from 0.25 to 32 mg/ml. Among these, Terminalia chebula> Retz. (Combretaceae) and Syzygium cumini (L.) Skeels (Myrtaceae) showed the most promising broad spectrum antibacterial properties, inhibiting all of the strains tested, especially Vibrio cholerae, Aeromonas hydrophila and Bacillus subtilis, with MBC ranging from 0.25 to 4 mg/ml. Phenolics and flavonoids were found to be present in the extracts. Conclusion: The findings provide support for the use of this plant in traditional medicine for treatment of diarrheoa, especially cholera

Benzopyrans: Part 47^†- Reactions of 3-(β-dimethylaminoacryloyl)-1- benzopyran- 4-one with some nitrogen nucleophiles

2666-2669The title pyranone 1 gives a mixture of pyridines 4 and 7 with ammonia, pyridine 5 and pyrazole 10 with phenylhydrazine, and pyridine N-oxide 8 with hydroxylamine