Menstruation and related disorders in Indian adolescent girls: an observational study

Background: Menstrual disorders are a common presentation and leading reasons for the physician office visits by adolescents. With this preview, we have made an attempt to evaluate the current changes in the age of menarche, menstruation patterns, the incidence of common menstrual disorders and their etiologies. Aims and objectives of the current study was to evaluate the menstrual disorders, their etiology and treatment modalities in adolescents in tertiary health care setup.Methods: An observational study was carried out on female patients in adolescent age group attending OPD of obstetrics and gynecology, Grant Government Medical College, Mumbai, India. The selected women were explained about the protocol, purpose of the study and were requested to complete the questionnaires to elicit information relating to demographic features, menarche age, and menstrual characteristics. Results were tabulated and analyzed.Results: A total number of 100 cases were included in this study, among them majority were in 16-19 years age group (64%), 79% of the study population belong to the lower class. It was observed that 55% study subject had dysmenorrhoea, 65% had irregular menses, 52% oligomenorrhoea, 13% polymenorrhoea, 28% had menorrhagia, 2% amenorrhea, 10% with PCOS and 2% with endometriosis, 4% with hypothyroidism, 4% with hyperprolactinemia. Most of the study subject responded well to analgesics and hormonal therapy.Conclusions: Menstrual irregularity needs to be evaluated with utmost sensitivity and treated promptly. Lack of sufficient knowledge, awareness regarding menstruation among adolescent girls and social embarrassment should be tackled with education

Hyperuricemia and maternal outcome in pregnancy induced hypertension: prospective study in a tertiary care center in Mumbai, India

Background: Pregnancy induced hypertension, preeclampsia, eclampsia are serious complications of pregnancy. They are the leading causes of morbidity and mortality in the world and one of the leading causes for perinatal mortality also. It is the systemic disease affecting all vital organs including the fetus. Estimation of biochemical markers can give us the indication of the severity and prediction of the outcome. Serum uric acid is the end product of purine metabolism, amongst others like creatinine, LDH, transaminases. Methods: It was a type of prospective descriptive study. The present study was conducted in department of obstetrics and gynecology, Tertiary care hospital, Mumbai, Maharashtra, India. Results: Pregnancy induced hypertension was most common in age group of 20-25 years, most common complication was preterm delivery which accounts for 43% of maternal complications. 60% of the cases with IUFD had serum uric acid level 8-8.9 mg/dl, 3% of the patients had HELLP syndrome. Conclusions: We found severity of complication associated with raise in serum uric acid levels.

Peripartum cardiomyopathy in uncorrected tetralogy of fallot: a case report

Tetralogy of Fallot (ToF) is the most common cyanotic congenital heart with incidence about 10% of all congenital heart disease. Natural survival to the fourth decade is extremely rare (only about 3%), but there is a tendency of increasing number of women with cyanotic congenital heart disease living 3 to 4 decades and are becoming pregnant. Because of significant physiology adaptation and changes, pregnancy and delivery process are troublesome for most unhealthy women, including those with uncorrected ToF. For ToF patients, it remains an important cause of maternal morbidity (62.5%), and even mortality (10%) and has significant effects on fetal outcome. Discussed below a case of pregnancy in a 30 year old woman with uncorrected ToF, dyspnoea class II of New York Heart Association, on 36th week pregnancy with complication of postpartum cardiomyopathy. Through dedicated medical care, patient's condition improvement can be seen. Prognosis of pregnancy in patient with uncorrected ToF is poor without optimal obstetrical and medical management

Pan-Cancer Analysis of lncRNA Regulation Supports Their Targeting of Cancer Genes in Each Tumor Context

Long noncoding RNAs (lncRNAs) are commonly dys-regulated in tumors, but only a handful are known toplay pathophysiological roles in cancer. We inferredlncRNAs that dysregulate cancer pathways, onco-genes, and tumor suppressors (cancer genes) bymodeling their effects on the activity of transcriptionfactors, RNA-binding proteins, and microRNAs in5,185 TCGA tumors and 1,019 ENCODE assays.Our predictions included hundreds of candidateonco- and tumor-suppressor lncRNAs (cancerlncRNAs) whose somatic alterations account for thedysregulation of dozens of cancer genes and path-ways in each of 14 tumor contexts. To demonstrateproof of concept, we showed that perturbations tar-geting OIP5-AS1 (an inferred tumor suppressor) andTUG1 and WT1-AS (inferred onco-lncRNAs) dysre-gulated cancer genes and altered proliferation ofbreast and gynecologic cancer cells. Our analysis in-dicates that, although most lncRNAs are dysregu-lated in a tumor-specific manner, some, includingOIP5-AS1, TUG1, NEAT1, MEG3, and TSIX, synergis-tically dysregulate cancer pathways in multiple tumorcontexts

Every Speed Breaker Is A Source Of Power

ABSTRACT Electricity in India, is a big problem which is faced by people who reside in the country. Electricity is the form of energy, Electricity is a basic part of nature and it is one of our most widely used forms of energy. We get electricity, which is a secondary energy source, from the conversion of other sources of energy, like coal, natural gas, oil, nuclear power and other natural sources, which are called primary sources. Before electricity generation began slightly over 100 years ago, we use kerosene lamps, and rooms were warmed by wood-burning or coal burning stoves. Direct current (DC) electricity had been used in arc lights for outdoor lighting. In the late-1800s, Nikola Tesla pioneered the generation, transmission, and use of alternating current (AC) electricity, which can be transmitted over much greater distances than direct current. Generating electricity by speed breakers is innovative and useful concept. Researches show that the world has already had its enough Shares of its energy resources. Fossil fuels pollute the environment. Nuclear energy requires careful handling of both raw as well as waste material. The focus now is shifting more and more towards the renewable sources of energy, which are essentially, nonpolluting. Energy conservation is the cheapest new source of energy. The utilization of energy is an indication of the growth of a nation. One might conclude that to be materially rich and prosperous, a human being needs to consume more and more energy. And this paper is best source of energy that we get in day to day life. This paper is presenting the study of electricity generation through the speed breaker mechanism

Scientometric analysis of biotechnology research output in India during 2008-2017

In this study a scientometric analysis of the biotechnology research output of India during 2008-2017 was performed based on the information available in SCOPUS database. This study analyses the research output of India in biotechnology research on different parameters including the growth, global publication share and rank, contribution of major international collaborative partners and subject areas, contribution and citation impact of the most productive authors, institutions and journals. The United States ranks first in terms of number of publications, h-index and average citations per paper. A total of 5573 papers were published by India during 2008-2017, which received 80530 citations with an average of 14.45 citations per paper. Almost 48.79% publications are in the field of biochemistry, genetics and molecular biology. The most productive Indian institution in biotechnology research was Indian Institute of Technology, Delhi followed by Council of Scientific and Industrial Research and Vellore Institute of Technology. Top twenty most productive institutions contributed 30.50% share of total publications with an average of 85 publications per institute

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Peripartum cardiomyopathy in uncorrected tetralogy of fallot: a case report

Tetralogy of Fallot (ToF) is the most common cyanotic congenital heart with incidence about 10% of all congenital heart disease. Natural survival to the fourth decade is extremely rare (only about 3%), but there is a tendency of increasing number of women with cyanotic congenital heart disease living 3 to 4 decades and are becoming pregnant. Because of significant physiology adaptation and changes, pregnancy and delivery process are troublesome for most unhealthy women, including those with uncorrected ToF. For ToF patients, it remains an important cause of maternal morbidity (62.5%), and even mortality (10%) and has significant effects on fetal outcome. Discussed below a case of pregnancy in a 30 year old woman with uncorrected ToF, dyspnoea class II of New York Heart Association, on 36th week pregnancy with complication of postpartum cardiomyopathy. Through dedicated medical care, patient's condition improvement can be seen. Prognosis of pregnancy in patient with uncorrected ToF is poor without optimal obstetrical and medical management