Unusual presentation: fracture neck femur in 18 months old child

An 18 months old child was brought to the emergency department with alleged history of trauma due to hit by two wheeler and sustained injury over right hip. Child was not able to move the right lower limb. Physical examination of child revealed contusion over right hip region and injury over perineal region. There was no active vaginal bleeding. Rest of the systemic examination was normal. Routine blood was normal. On X-ray of pelvis with both hip showed fracture of neck femur on right side without any pelvic injury. Patient was treated with hip spica cast and complete bed rest for 1 month. After 1 month of the treatment, on follow-up the patient was able to weight bear and fractured was united on X-ray

Monoazo reactive dyes: Synthesis and application on cotton, silk and wool fibers

Mono azo reactive dyes are mostly used in textiles industries. The current study was developed to synthesize and apply mono azo reactive dyes. The primary goal of this research article is to highlight synthesized dyes with outstanding fixing properties for the dyeing and printing sectors to invent in future. Diazotized o-anisidine was coupled with several 4-amino-4ʼ-hydroxy benzilidene acetophenone cyanurated coupling component including H-acid, Gamma acid, J-acid, N-methyl J-acid, N-phenyl J-acid, K- acid and peri acid, to create a variety of monoazo reactive dyes. IR and elemental analyses were used to describe them. Moreover, the dyeing capabilities of each of these dyes on silk, wool, and cotton have been evaluated. The wet fastness properties also evaluated. Synthesized mono azo reactive dyes have excellent fixation values as well as fastness properties.Os corantes reativos monoazo são usados principalmente nas indústrias têxteis. O presente estudo foi desenvolvido para sintetizar e aplicar corantes reativos mono azo. O objetivo principal deste artigo de pesquisa é destacar corantes sintetizados com excelentes propriedades de fixação para os setores de tingimento e estamparia investirem ainda mais. A o-anisidina diazotizada foi acoplada a vários componentes de acoplamento cianuratados de 4-amino-4'-hidroxi benzlideno acetofenona, incluindo ácido H, ácido gama, ácido J, ácido N metil J, ácido N-fenil J, ácido K e peri ácido, para criar uma variedade de corantes reativos monoazo. Análises elementares de IR e nitrogênio foram usadas para descrevê-los. Além disso, as capacidades de tingimento de cada um desses corantes em seda, lã e algodão foram avaliadas. As propriedades de resistência à umidade também foram avaliadas. Os corantes reativos monoazo sintetizados têm excelentes valores de fixação, bem como propriedades de solidez

Tendências na síntese e aplicação de alguns corantes reativos: Uma revisão

From last 25 years that many researchers have developed the novel reactive dyes with modification in structure of reactive dyes. In the present review paper concentrated development of reactive dyes. The review paper is focused on the highlight such dyes have having excellent dyeing properties and wet-fastness properties. This review paper express the monstrous impression of reactive dyes on the textiles coloration industry. Particularized details are given regarding evolution in the chemistry of reactive structure systems. It is additionally mentioned pointed out that advance research is mandatory to enhance dye fixation and wet-fastness properties. Reactive dyes have been used for the past hundred years for dyeing of cellulosic fabrics. A reactive dye has a chromophore, which is a group or an atom that is responsible for the dye’s colour. It has a component which reacts with the fabric or substrate. They have excellent fastness features due to the presence of covalent bonds that takes place during dyeing. The dyeing industry is dominated by the parties who can create dyes having excellent dyeing efficiency, stable, can be resistant to chemical actions and be affordable. In this review on development of synthesis reactive dyes has been provided. This review paper concentrated on research of reactive groups type. En los últimos veinticinco años, muchos investigadores han desarrollado nuevos colorantes reactivos con modificaciones en la estructura de los colorantes reactivos. En este artículo de revisión, nos enfocamos en el desarrollo de colorantes reactivos. El artículo de revisión se centra en resaltar tales tintes con excelentes propiedades de teñido y propiedades de solidez a la humedad. Este artículo de revisión expresa la monstruosa impresión de los colorantes reactivos en la industria del teñido textil. Se dan detalles particulares sobre la evolución en la química de los sistemas de estructura reactiva. Además, se menciona que se necesita investigación avanzada para mejorar las propiedades de fijación del tinte y resistencia a la humedad. Los colorantes reactivos se han utilizado durante los últimos cien años para teñir tejidos celulósicos. Un tinte reactivo tiene un cromóforo, que es un grupo o átomo responsable del color del tinte. Tiene un componente que reacciona con el tejido o sustrato. Tienen excelentes características de solidez debido a la presencia de enlaces covalentes que se producen durante el teñido. La industria del teñido está dominada por partes que pueden crear tintes con excelente eficiencia de teñido, estables, resistentes a los químicos y asequibles. En esta revisión, se proporcionó el desarrollo de colorantes de síntesis reactiva. Este artículo de revisión se centró en la investigación de tipo de grupo reactivo.Nos últimos vinte e cinco anos, muitos pesquisadores desenvolveram novos corantes reativos com modificações na estrutura dos corantes reativos. No presente artigo de revisão, concentrou-se o desenvolvimento de corantes reativos. O artigo de revisão está focado no destaque que tais corantes têm com excelentes propriedades de tingimento e propriedades de resistência à umidade. Este artigo de revisão expressa a impressão monstruosa de corantes reativos na indústria de coloração têxtil. Detalhes particulares são dados sobre a evolução na química de sistemas de estrutura reativa. Além disso, é mencionado que pesquisas avançadas são necessárias para melhorar a fixação do corante e as propriedades de resistência à umidade. Os corantes reativos têm sido usados nos últimos cem anos para tingir tecidos celulósicos. Um corante reativo tem um cromóforo, que é um grupo ou átomo responsável pela cor do corante. Tem um componente que reage com o tecido ou substrato. Possuem excelentes características de solidez devido à presença de ligações covalentes que ocorrem durante o tingimento. A indústria de tingimento é dominada pelas partes que podem criar corantes com excelente eficiência de tingimento, estáveis, resistentes a ações químicas e acessíveis. Nesta revisão, o desenvolvimento de corantes reativos de síntese foi fornecido. Este artigo de revisão concentrou-se na pesquisa do tipo grupos reativos

Orthopaedic aspect of anatomy and radiology of proximal femur

Femoral pathology is common in relation to the orthopedic. There is complex anatomy of the proximal femur and hip joint. So, its knowledge regarding anatomy and radiological correlation is necessary to the well-known fact for the orthopedics for the routine day to day practice. This review article briefly illustrates important anatomical and radiological aspect of the proximal femur

Extreme Smog Challenge of India Intensified by Increasing Lower Tropospheric Stability

Extreme smog in India widely impacts air quality in late autumn and winter months. While the links between emissions, air quality and health impacts are well-recognized, the association of smog and its intensification with climatic trends in the lower troposphere, where aerosol pollution and its radiative effects manifest, are not understood well. Here we use long-term satellite data to show a significant increase in aerosol exceedances over northern India, resulting in sustained atmospheric warming and surface cooling trends over the last two decades. We find several lines of evidence suggesting these aerosol radiative effects have induced a multidecadal (1980–2019) strengthening of lower tropospheric stability and increase in relative humidity, leading to over fivefold increase in poor visibility days. Given this crucial aerosol-radiation-meteorological feedback driving the smog intensification, results from this study would help inform mitigation strategies supporting stronger region-wide measures, which are critical for solving the smog challenge in India

CACHD1 is an α2δ-like protein that modulates CaV3 voltage-gated calcium channel activity

The putative cache (Ca2+ channel and chemotaxis receptor) domain containing 1 (CACHD1) protein has predicted structural similarities to members of the alpha2delta voltage-gated Ca2+ channel (VGCC) auxiliary subunit family. CACHD1 mRNA and protein were highly expressed in the male mammalian CNS, in particular in the thalamus, hippocampus and cerebellum, with a broadly similar tissue distribution to CaV3 subunits, in particular, CaV3.1. In expression studies, CACHD1 increased cell-surface localization of CaV3.1 and these proteins were in close proximity at the cell surface consistent with the formation of CACHD1-CaV3.1 complexes. In functional electrophysiological studies, co-expression of human CACHD1 with CaV3.1, CaV3.2 and CaV3.3 caused a significant increase in peak current density and corresponding increases in maximal conductance. By contrast, alpha2delta-1 had no effect on peak current density or maximal conductance in either CaV3.1, CaV3.2 or CaV3.3. Comparison of CACHD1-mediated increases in CaV3.1 current density and gating currents revealed an increase in channel open probability. In hippocampal neurons from male and female E19 rats, CACHD1 overexpression increased CaV3-mediated action potential (AP) firing frequency and neuronal excitability. These data suggest that CACHD1 is structurally an alpha2delta-like protein that functionally modulates CaV3 voltage-gated calcium channel activity

Synthesis, docking study and biological evaluation of novel N-(1,3-benzothiazole-2-yl)-2-(pyridine-3-ylformohydrazido) acetamide derivatives

1721-1737A series of N-(1,3-benzothiazole-2-yl)-2(pyridine-3-ylformohydrazido acetamide derivatives have been synthesized by facile and efficient conventional method. The structures of the compounds have been elucidated with the aid of elemental analysis, IR, ESI-MS, and 1H and 13C NMR spectral data. Molecular docking revealed that synthesized derivatives and target proteins are actively involved in the binding pattern and had a significant correlation with biological activity. Molecular dynamics studies have also been performed and ADME parameters for the synthesized compounds determined. Biological evaluation of all synthesized compounds have been carried out in vitro for their antibacterial, antituberculosis and antifungal efficacy against various bacterial and fungal strains and H37Rv. The different studies indicate that newly synthesized compounds possess moderate to good biological activities

Quantifying the Impact of Immune History and Variant on SARS-CoV-2 Viral Kinetics and Infection Rebound: A Retrospective Cohort Study

BACKGROUND: The combined impact of immunity and SARS-CoV-2 variants on viral kinetics during infections has been unclear. METHODS: We characterized 1,280 infections from the National Basketball Association occupational health cohort identified between June 2020 and January 2022 using serial RT-qPCR testing. Logistic regression and semi-mechanistic viral RNA kinetics models were used to quantify the effect of age, variant, symptom status, infection history, vaccination status and antibody titer to the founder SARS-CoV-2 strain on the duration of potential infectiousness and overall viral kinetics. The frequency of viral rebounds was quantified under multiple cycle threshold (Ct) value-based definitions. RESULTS: Among individuals detected partway through their infection, 51.0% (95% credible interval [CrI]: 48.3-53.6%) remained potentially infectious (Ct CONCLUSIONS: SARS-CoV-2 viral kinetics are partly determined by immunity and variant but dominated by individual-level variation. Since booster vaccination protects against infection, longer clearance times for BA.1-infected, boosted individuals may reflect a less effective immune response, more common in older individuals, that increases infection risk and reduces viral RNA clearance rate. The shifting landscape of viral kinetics underscores the need for continued monitoring to optimize isolation policies and to contextualize the health impacts of therapeutics and vaccines. FUNDING: Supported in part by CDC contract #200-2016-91779, a sponsored research agreement to Yale University from the National Basketball Association contract #21-003529, and the National Basketball Players Association

Helicobacter species are associated with possible increase in risk of biliary lithiasis and benign biliary diseases

<p>Abstract</p> <p>Background</p> <p>Hepato-biliary tract lithiasis is common and present either as pain or as asymptomatic on abdominal ultrasonography for other causes. Although the DNA of <it>Helicobacter </it>species are identified in the gallbladder bile, tissue or stones analyzed from these cases, still a causal relationship could not be established due to different results from different geographical parts.</p> <p>Methods</p> <p>A detailed search of pubmed and pubmedcentral was carried out with key words <it>Helicobacter </it>and gallbladder, gallstones, hepaticolithiasis, cholelithiasis and choledocholithiasis, benign biliary diseases, liver diseases. The data was entered in a data base and meta analysis was carried out. The analysis was carried out using odds ratio and a fixed effect model, 95% confidence intervals for odds ratio was calculated. Chi square test for heterogeneity was employed. The overall effect was calculated using Z test.</p> <p>Results</p> <p>A total of 12 articles were identified. One study used IgG for diagnosis while others used the PCR for Ure A gene, 16 S RNA or Cag A genes. A couple of studies used culture or histopathology besides the PCR. The cumulative results show a higher association of <it>Helicobacter </it>with chronic liver diseases (30.48%), and stone diseases (42.96%)(OR 1.77 95% CI 1.2–2.58; Z = 2.94, p = 0.003), the effect of each could not be identified as it was difficult to isolate the effect of helicobacter due to mixing of cases in each study.</p> <p>Conclusion</p> <p>The results of present meta analysis shows that there is a slight higher risk of cholelithiasis and benign liver disease (OR 1.77), however due to inherent inability to isolate the effect of stone disease from that of other benign lesions it is not possible to say for sure that <it>Helicobacter </it>has a casual relationship with benign biliary disease or stone disease or both.</p

Activating the knowledge-to-action cycle for geriatric care in India

Despite a rapidly aging population, geriatrics - the branch of medicine that focuses on healthcare of the elderly - is relatively new in India, with many practicing physicians having little knowledge of the clinical and functional implications of aging. Negative attitudes and limited awareness, knowledge or acceptance of geriatrics as a legitimate discipline contribute to inaccessible and poor quality care for India's old. The aim of this paper is to argue that knowledge translation is a potentially effective tool for engaging Indian healthcare providers in the delivery of high quality geriatric care. The paper describes India's context, including demographics, challenges and current policies, summarizes evidence on provider behaviour change, and integrates the two in order to propose an action plan for promoting improvements in geriatric care