16 research outputs found
In Vivo Efficacy Study of Milk Thistle Extract (ETHIS-094™) in STAM™ Model of Nonalcoholic Steatohepatitis
Partial role of nitric oxide in infarct size limiting effect of quercetin and rutin against ischemia-reperfusion injury in normal and diabetic rats
207-210Reperfusion injury is remarkable clinical
issue that needs to be resolved as ischemia-reperfusion is a common phenomenon
encountered in numerous clinical situations. The present communication report
the involvement of nitric oxide (NO) in cardioprotection offered by flavonoids
(rutin and quercetin) against myocardial ischemia reperfusion. Rutin produced
better cardioprotection than quercetin in normal and diabetic rats. The
observed cardioprotection offered with quercetin and rutin was partially
abolished by prior administration of nitric oxide synthase inhibitor, L-NAME
(N-nitro-L-arginine methyl ester) in both normal and diabetic rats. L-NAME
abolished the cardioprotective actions of rutin more strongly than the
cardioprotective actions of quercetin. However, mechanistic study with NOS
inhibitor implied the possible partial role of nitric oxide in infarct size
limiting effect of quercetin and ruti