Проблеми бюджетної політики в Україні та шляхи їх подолання

Пастушенко А. Г. Проблеми бюджетної політики в Україні та шляхи їх подолання / А. Г. Пастушенко // Економіко-правовий розвиток сучасної України : матер. ІIІ Всеукр. наук. конф. студ., аспір. та молодих вчених (22-23 листопада 2013 р., м. Одеса) / за ред. д.е.н., проф. О. М. Кібік, д.ю.н., проф. О. П. Подцерковного ; Національн. ун-т «Одеська юридична академія» – Одеса : Фенікс, 2013. – С. 43-45

Applicability of QKD: TerraQuantum view on the NSA's scepticism

Quantum communication offers unique features that have no classical analog, in particular, it enables provably secure quantum key distribution (QKD). Despite the benefits of quantum communication are well understood within the scientific community, the practical implementations sometimes meet with scepticism or even resistance. In a recent publication [1], NSA claims that QKD is inferior to "quantum-resistant" cryptography and does not recommend it for use. Here we show that such a sceptical approach to evaluation of quantum security is not well justified. We hope that our arguments will be helpful to clarify the issue

EXTERNAL ROLLING OF A POLYGON ON CLOSED CURVILINEAR PROFILE

The design of a helical surface tillage tool made of a developable helicoid section has been calculated using the methods of analytical and differential geometry, the theory of surfaces, the systems of computer-generated graphics and mathematics. A helical tool in the form of a skeleton cylinder made of bars, where there is a helical surface made of arranged sheet metal, has been developed. Such a design prevents a helical surface from becoming clogged with soil. The suggested tool operates as a roller and the soil can easily pass through the gaps between the bars. New helical harrow tools have been designed and made for this experiment. An experimental harrow equipped with helical tools has been made and used to conduct a field research. The research was aimed at determining the optimal kinematic parameters and the pattern of field movement, which allow performing the technological process of soil tillage with the performance indices that meet the agricultural requirements

Experimental demonstration of scalable quantum key distribution over a thousand kilometers

Secure communication over long distances is one of the major problems of modern informatics. Classical transmissions are recognized to be vulnerable to quantum computer attacks. Remarkably, the same quantum mechanics that engenders quantum computers offers guaranteed protection against such attacks via quantum key distribution (QKD). Yet, long-distance transmission is problematic since the essential signal decay in optical channels occurs at a distance of about a hundred kilometers. We propose to resolve this problem by a QKD protocol, further referred to as the Terra Quantum QKD protocol (TQ-QKD protocol). In our protocol, we use semiclassical pulses containing enough photons for random bit encoding and exploiting erbium amplifiers to retranslate photon pulses and, at the same time, ensuring that at the chosen pulse intensity only a few photons could go outside the channel even at distances of about a hundred meters. As a result, an eavesdropper will not be able to efficiently utilize the lost part of the signal. The central component of the TQ-QKD protocol is the end-to-end loss control of the fiber-optic communication line since optical losses can in principle be used by the eavesdropper to obtain the transmitted information. However, our control precision is such that if the degree of the leak is below the detectable level, then the leaking states are quantum since they contain only a few photons. Therefore, available to the eavesdropper parts of the bit encoding states representing `0' and `1' are nearly indistinguishable. Our work presents the experimental demonstration of the TQ-QKD protocol allowing quantum key distribution over 1079 kilometers. Further refining the quality of the scheme's components will expand the attainable transmission distances. This paves the way for creating a secure global QKD network in the upcoming years.Comment: 23 pages (main text: 15 pages, supplement: 8 pages), 21 figures (main text: 7 figures, supplement: 14 figures

Очистка воды от примесей фенола с использованием электроразрядной установки

У статті розглянуто підхід до очищення води від складних забруднень, за допомогою електророзрядної технології. Проаналізовано можливості очистки води, забрудненої домішками фенолу, за допомогою дугового розряду.The article deals with the approach to water purification from complex contaminants, using electrodischarge technology. The possibilities of water purification, contaminated with phenol impurities, with the help of arc discharge have been analyzed.В статье рассмотрен подход к очистке воды от сложных загрязнений, с помощью электроразрядной технологии. Проанализированы возможности очистки воды, загрязненной примесями фенола, с помощью дугового разряда

Reliability design of rotors for orbital hydraulic motors

The reliability of orbital hydraulic motors which are used in mechatronic systems with a hydraulic drive for active working tools on self-propelled machinery is a pressing engineering problem. To increase the reliability, a specific design method was proposed. It required development of a mathematical apparatus and a calculation algorithm. The mathematical tools allowed to realize the method for determination of hydraulic motor reliability by simulating changes in a technical state of the rotors in a hydraulic motor. A program, which has been developed, enabled modeling the conjugation of external and internal rotors. The program implemented an algorithm for the sequence of calculating the parameters for the external and internal rotors. The proposed program made it possible to obtain a three-dimensional image of zones with admissible interfaces which ensure the efficient and reliable operation of orbital motors. The modeling of working capacity change for an orbital motor has established some dependence. The changes in the number of teeth and overall dimensions of the rotor in the investigated range enabled to develop a standard size range for hydraulic machines, which operate in mechatronic drive systems for active working tools on self-propelled machinery

Experience in the Design and Production of Recombinant Oral Vaccine «Revax VZT»

Objective of the work was the production of recombinant vaccine «RevaxVZT» in tablet dosage form against hepatitis B and pathogenic for humans orthopoxviruses for further clinical trials. Materials and methods. Recombinant strain b7.5S2-S of vaccinia virus carrying a DNA fragment of hepatitis B virus inserted into thymidinekinase gene was used as an active component of the vaccine. Microbiological, virological, physical, physical and chemical, and biotechnological methods were used for studying the quality of the drug and technological processes. Results and discussion. Results of technological control for semi-finished products and final products of the vaccine “Revax VZT” showed the possibility of using certified hardware-processing line of “TEOVac” for its manufacturing. Same technology can be potentially used with other live tableted embryo smallpox vaccines too. For the development of the vaccine “Revax VZT” with the specific activity of not less than 1.0·107 PFu/tablet, it is necessary to use a dry virus-containing material with activity not less than 2.0·108 PFU/g which is produced by freeze-drying of liquid virus-containing preparation with the activity of not less than 1.0·108 PFU/g, preferentially propagated from chorionic allantoic membranes of chicken embryos as a substrate for viral biomass accumulation

Dynamic force microscopy for imaging of viruses under physiological conditions

Dynamic force microscopy (DFM) allows imaging of the structure and the assessment of the function of biological specimens in their physiological environment. In DFM, the cantilever is oscillated at a given frequency and touches the sample only at the end of its downward movement. Accordingly, the problem of lateral forces displacing or even destroying bio-molecules is virtually inexistent as the contact time and friction forces are reduced. Here, we describe the use of DFM in studies of human rhinovirus serotype 2 (HRV2) weakly adhering to mica surfaces. The capsid of HRV2 was reproducibly imaged without any displacement of the virus. Release of the genomic RNA from the virions was initiated by exposure to low pH buffer and snapshots of the extrusion process were obtained. In the following, the technical details of previous DFM investigations of HRV2 are summarized

Fat1 deletion promotes hybrid EMT state, tumour stemness and metastasis

FAT1, which encodes a protocadherin, is one of the most frequently mutated genes in human cancers1–5. However, the role and the molecular mechanisms by which FAT1 mutations control tumour initiation and progression are poorly understood. Here, using mouse models of skin squamous cell carcinoma and lung tumours, we found that deletion of Fat1 accelerates tumour initiation and malignant progression and promotes a hybrid epithelial-to-mesenchymal transition (EMT) phenotype. We also found this hybrid EMT state in FAT1-mutated human squamous cell carcinomas. Skin squamous cell carcinomas in which Fat1 was deleted presented increased tumour stemness and spontaneous metastasis. We performed transcriptional and chromatin profiling combined with proteomic analyses and mechanistic studies, which revealed that loss of function of FAT1 activates a CAMK2–CD44–SRC axis that promotes YAP1 nuclear translocation and ZEB1 expression that stimulates the mesenchymal state. This loss of function also inactivates EZH2, promoting SOX2 expression, which sustains the epithelial state. Our comprehensive analysis identified drug resistance and vulnerabilities in FAT1-deficient tumours, which have important implications for cancer therapy. Our studies reveal that, in mouse and human squamous cell carcinoma, loss of function of FAT1 promotes tumour initiation, progression, invasiveness, stemness and metastasis through the induction of a hybrid EMT state