Finite-size effects and collective vibrations in the inner crust of neutron stars

We study the linear response of the inner crust of neutron stars within the Random Phase Approximation, employing a Skyrme-type interaction as effective interaction. We adopt the Wigner-Seitz approximation, and consider a single unit cell of the Coulomb lattice which constitutes the inner crust, with a nucleus at its center, surrounded by a sea of free neutrons. With the use of an appropriate operator, it is possible to analyze in detail the properties of the vibrations of the surface of the nucleus and their interaction with the modes of the sea of free neutrons, and to investigate the role of shell effects and of resonant states

Characterization of two new alleles at the goat CSN1S2 locus.

Two novel alleles at the goat CSN1S2 locus have been identified: CSN1S2(F) and CSN1S2(D). Sequence analyses revealed that the CSN1S2(F) allele is characterized by a G --> A transition at the 13th nucleotide in exon 3 changing the seventh amino acid of the mature protein from Val to Ile. The CSN1S2(D) allele, apparently associated with a decreased synthesis of alpha s2-casein, is characterized by a 106-bp deletion, involving the last 11 bp of the exon 11 and the first 95 bp of the following intron. Methods (PCR-RFLP and PCR) for identification of carriers of these alleles have been developed

Giant Monopole Resonances and nuclear incompressibilities studied for the zero-range and separable pairing interactions

Background: Following the 2007 precise measurements of monopole strengths in tin isotopes, there has been a continuous theoretical effort to obtain a precise description of the experimental results. Up to now, there is no satisfactory explanation of why the tin nuclei appear to be significantly softer than 208Pb. Purpose: We determine the influence of finite-range and separable pairing interactions on monopole strength functions in semi-magic nuclei. Methods: We employ self-consistently the Quasiparticle Random Phase Approximation on top of spherical Hartree-Fock-Bogolyubov solutions. We use the Arnoldi method to solve the linear-response problem with pairing. Results: We found that the difference between centroids of Giant Monopole Resonances measured in lead and tin (about 1 MeV) always turns out to be overestimated by about 100%. We also found that the volume incompressibility, obtained by adjusting the liquid-drop expression to microscopic results, is significantly larger than the infinite-matter incompressibility. Conclusions: The zero-range and separable pairing forces cannot induce modifications of monopole strength functions in tin to match experimental data.Comment: 11 RevTeX pages, 16 figures, 1 table, extended versio

Discrete surface growth process as a synchronization mechanism for scale free complex networks

We consider the discrete surface growth process with relaxation to the minimum [F. Family, J. Phys. A {\bf 19} L441, (1986).] as a possible synchronization mechanism on scale-free networks, characterized by a degree distribution $P(k) \sim k^{-\lambda}$, where $k$ is the degree of a node and $\lambda$ his broadness, and compare it with the usually applied Edward-Wilkinson process [S. F. Edwards and D. R. Wilkinson, Proc. R. Soc. London Ser. A {\bf 381},17 (1982) ]. In spite of both processes belong to the same universality class for Euclidean lattices, in this work we demonstrate that for scale-free networks with exponents $\lambda<3$ this is not true. Moreover, we show that for these ubiquitous cases the Edward-Wilkinson process enhances spontaneously the synchronization when the system size is increased, which is a non-physical result. Contrarily, the discrete surface growth process do not present this flaw and is applicable for every $\lambda$.Comment: 8 pages, 4 figure

QoL in Southtyrol T1D Pediatric Patients Psycho-social Well-being, Quality of Life, Health Status and Family Conflicts in a South-tyrolean Group of Pediatric Patients with Diabetes Mellitus Type I

Background:Psychological well-being and metabolic control in pediatric patients with diabetes mellitus type I (T1D) could be negatively influenced by adolescence current age, age at the diagnosis, lower economic condition and lower education status and by higher family conflict. However, they reported lower or comparable levels of emotional difficulties compared with normative population.Objective:To understand psycho-social symptoms, quality of life, health status and family conflicts of pediatric patients with T1D in the unique cultural environment of South-Tyrol. The present study has two goals. The first is to understand psychological symptoms and to investigatethe possible risk factors. The second deals with the subgroup of adolescents, comparing their psychological functioning with a healthy control group.Methods:Patients (n=59) with a mean age of 13.19 years (SD=3.26; range 8\u201318) were contacted at the Day Hospital check-ups and self-and proxy-reported questionnaires were administered: CBCL/ YSR, DFCS-R, DQOLY-SF. From this group, 45 patients aged 11\u201318 were matched by gender and age in months with a control group of healthy peers. Results:Glycemic control was severely inadequate and a subgroup of patients showed lower indexes of total competencies and activities performed, especially if they were of poor economic condition and had the illness for a longer duration. The adolescent patients self-reported better psychological functioning than their healthy peers, except for conduct problems. Conclusions:Specific psycho-social interventions should address the dangerous levels of metabolic control indexes and mitigate the patients\u2019 conduct problems

Nuclear energy density optimization: Shell structure

Nuclear density functional theory is the only microscopical theory that can be applied throughout the entire nuclear landscape. Its key ingredient is the energy density functional. In this work, we propose a new parameterization UNEDF2 of the Skyrme energy density functional. The functional optimization is carried out using the POUNDerS optimization algorithm within the framework of the Skyrme Hartree-Fock-Bogoliubov theory. Compared to the previous parameterization UNEDF1, restrictions on the tensor term of the energy density have been lifted, yielding a very general form of the energy density functional up to second order in derivatives of the one-body density matrix. In order to impose constraints on all the parameters of the functional, selected data on single-particle splittings in spherical doubly-magic nuclei have been included into the experimental dataset. The agreement with both bulk and spectroscopic nuclear properties achieved by the resulting UNEDF2 parameterization is comparable with UNEDF1. While there is a small improvement on single-particle spectra and binding energies of closed shell nuclei, the reproduction of fission barriers and fission isomer excitation energies has degraded. As compared to previous UNEDF parameterizations, the parameter confidence interval for UNEDF2 is narrower. In particular, our results overlap well with those obtained in previous systematic studies of the spin-orbit and tensor terms. UNEDF2 can be viewed as an all-around Skyrme EDF that performs reasonably well for both global nuclear properties and shell structure. However, after adding new data aiming to better constrain the nuclear functional, its quality has improved only marginally. These results suggest that the standard Skyrme energy density has reached its limits and significant changes to the form of the functional are needed.Comment: 18 pages, 13 figures, 12 tables; resubmitted for publication to Phys. Rev. C after second review by refere

Anatomy of the first six months of COVID-19 vaccination campaign in Italy.

We analyze the effectiveness of the first six months of vaccination campaign against SARS-CoV-2 in Italy by using a computational epidemic model which takes into account demographic, mobility, vaccines data, as well as estimates of the introduction and spreading of the more transmissible Alpha variant. We consider six sub-national regions and study the effect of vaccines in terms of number of averted deaths, infections, and reduction in the Infection Fatality Rate (IFR) with respect to counterfactual scenarios with the actual non-pharmaceuticals interventions but no vaccine administration. Furthermore, we compare the effectiveness in counterfactual scenarios with different vaccines allocation strategies and vaccination rates. Our results show that, as of 2021/07/05, vaccines averted 29, 350 (IQR: [16, 454-42, 826]) deaths and 4, 256, 332 (IQR: [1, 675, 564-6, 980, 070]) infections and a new pandemic wave in the country. During the same period, they achieved a -22.2% (IQR: [-31.4%; -13.9%]) IFR reduction. We show that a campaign that would have strictly prioritized age groups at higher risk of dying from COVID-19, besides frontline workers and the fragile population, would have implied additional benefits both in terms of avoided fatalities and reduction in the IFR. Strategies targeting the most active age groups would have prevented a higher number of infections but would have been associated with more deaths. Finally, we study the effects of different vaccination intake scenarios by rescaling the number of available doses in the time period under study to those administered in other countries of reference. The modeling framework can be applied to other countries to provide a mechanistic characterization of vaccination campaigns worldwide

The Adriatic Basin Forecasting System: new model and system development

The Adriatic Basin Forecasting System implemented within the framework of the ADRICOSM Partnership (ADRIatic sea integrated COstal areaS and river basin Management system), nested to the operational general circulation model of the Mediterranean Sea, has recently been upgraded both in terms of system design and model parameterizations. The operational forecast is now daily, producing 9 days forecast, and a new near real time quality control has been introduced. From the modeling point of view the system has been upgraded in resolution (vertically from 21 to 31 sigma levels, and horizontally from approximately 1/22° to approximately 1/45°). Realistic fresh water fluxes have been introduced through the surface boundary condition taking into account evaporation, precipitation and river runoff, and the Smolarckiwicz advection scheme has been changed to the MUSCL scheme. The details of these developments will be presented, together with the model validation in delayed and real time mod

The fine-tuning of TRAF2-GSTP1-1 interaction: effect of ligand binding and in situ detection of the complex

We provide the first biochemical evidence of a direct interaction between the glutathione transferase P1-1 (GSTP1-1) and the TRAF domain of TNF receptor-associated factor 2 (TRAF2), and describe how ligand binding modulates such an equilibrium. The dissociation constant of the heterocomplex is Kd¼0.3lM; however the binding affinity strongly decreases when the active site of GSTP1-1 is occupied by the substrate GSH (KdZ2.6lM) or is inactivated by oxidation (Kd¼1.7lM). This indicates that GSTP1-1’s TRAF2-binding region involves the GSH-binding site. The GSTP1-1 inhibitor NBDHEX further decreases the complex’s binding affinity, as compared with when GSH is the only ligand; this suggests that the hydrophobic portion of the GSTP1-1 active site also contributes to the interaction. We therefore hypothesize that TRAF2 binding inactivates GSTP1-1; however, analysis of the data, using a model taking into account the dimeric nature of GSTP1-1, suggests that GSTP1-1 engages only one subunit in the complex, whereas the second subunit maintains the catalytic activity or binds to other proteins. We also analyzed GSTP1-1’s association with TRAF2 at the cellular level. The TRAF2–GSTP1-1 complex was constitutively present in U-2OS cells, but strongly decreased in S, G2 and M phases. Thus the interaction appears regulated in a cell cycle-dependent manner. The variations in the levels of individual proteins seem too limited to explain the complex’s drastic decline observed in cells progressing from the G0/G1 to the S–G2–M phases. Moreover, GSH’s intracellular content was so high that it always saturated GSTP1-1. Interestingly, the addition of NBDHEX maintains the TRAF2–GSTP1-1 complex at low levels, thus causing a prolonged cell cycle arrest in the G2/M phase. Overall, these findings suggest that a reversible sequestration of TRAF2 into the complex may be crucial for cell cycle progression and that multiple factors are involved in the fine-tuning of this interactio