Active Stars in the Spectroscopic Survey of Mid-to-Late M Dwarfs Within 15pc

We present results from the volume-complete spectroscopic survey of 0.1-0.3M$_\odot$ M dwarfs within 15pc. This work discusses the active sample without close binary companions, providing a comprehensive picture of these 123 stars with H${\alpha}$ emission stronger than -1\unicode{xC5}. Our analysis includes rotation periods (including 31 new measurements), H${\alpha}$ equivalent widths, rotational broadening, inclinations, and radial velocities, determined using high-resolution, multi-epoch spectroscopic data from the TRES and CHIRON spectrographs supplemented by photometry from TESS and MEarth. Using this volume-complete sample, we establish that the majority of active, low-mass M dwarfs are very rapid rotators: specifically, 74$\pm$4% have rotation periods shorter than 2 days, while 19$\pm$4% have intermediate rotation periods of 2-20 days, and the remaining 8$\pm$3% have periods longer than 20 days. Among the latter group, we identify a population of stars with very high H${\alpha}$ emission, which we suggest is indicative of dramatic spindown as these stars transition from the rapidly to slowly rotating modes. We are unable to determine rotation periods for six stars and suggest that some of the stars without measured rotation periods may be viewed pole-on, as such stars are absent from the distribution of inclinations we measure; this lack notwithstanding, we recover the expected isotropic distribution of spin axes. Our spectroscopic and photometric data sets also allow us to investigate activity-induced radial-velocity variability, which we show can be estimated as the product of rotational broadening and the photometric amplitude of spot modulation.Comment: Accepted for publication in AJ; 18 pages, 12 figures, 3 table

Four-Round Concurrent Non-Malleable Commitments from One-Way Functions

How many rounds and which assumptions are required for concurrent non-malleable commitments? The above question has puzzled researchers for several years. Pass in [TCC 2013] showed a lower bound of 3 rounds for the case of black-box reductions to falsifiable hardness assumptions with respect to polynomial-time adversaries. On the other side, Goyal [STOC 2011], Lin and Pass [STOC 2011] and Goyal et al. [FOCS 2012] showed that one-way functions (OWFs) are sufficient with a constant number of rounds. More recently Ciampi et al. [CRYPTO 2016] showed a 3-round construction based on subexponentially strong one-way permutations. In this work we show as main result the first 4-round concurrent non-malleable commitment scheme assuming the existence of any one-way function. Our approach builds on a new security notion for argument systems against man-in-the-middle attacks: Simulation-Witness-Independence. We show how to construct a 4-round one-many simulation-witnesses-independent argument system from one-way functions. We then combine this new tool in parallel with a weak form of non-malleable commitments constructed by Goyal et al. in [FOCS 2014] obtaining the main result of our work

National Mesothelioma Virtual Bank: A standard based biospecimen and clinical data resource to enhance translational research

Background: Advances in translational research have led to the need for well characterized biospecimens for research. The National Mesothelioma Virtual Bank is an initiative which collects annotated datasets relevant to human mesothelioma to develop an enterprising biospecimen resource to fulfill researchers' need. Methods: The National Mesothelioma Virtual Bank architecture is based on three major components: (a) common data elements (based on College of American Pathologists protocol and National North American Association of Central Cancer Registries standards), (b) clinical and epidemiologic data annotation, and (c) data query tools. These tools work interoperably to standardize the entire process of annotation. The National Mesothelioma Virtual Bank tool is based upon the caTISSUE Clinical Annotation Engine, developed by the University of Pittsburgh in cooperation with the Cancer Biomedical Informatics Grid™ (caBIG™, see http://cabig.nci.nih.gov). This application provides a web-based system for annotating, importing and searching mesothelioma cases. The underlying information model is constructed utilizing Unified Modeling Language class diagrams, hierarchical relationships and Enterprise Architect software. Result: The database provides researchers real-time access to richly annotated specimens and integral information related to mesothelioma. The data disclosed is tightly regulated depending upon users' authorization and depending on the participating institute that is amenable to the local Institutional Review Board and regulation committee reviews. Conclusion: The National Mesothelioma Virtual Bank currently has over 600 annotated cases available for researchers that include paraffin embedded tissues, tissue microarrays, serum and genomic DNA. The National Mesothelioma Virtual Bank is a virtual biospecimen registry with robust translational biomedical informatics support to facilitate basic science, clinical, and translational research. Furthermore, it protects patient privacy by disclosing only de-identified datasets to assure that biospecimens can be made accessible to researchers. © 2008 Amin et al; licensee BioMed Central Ltd

Candida dubliniensis fungemia: the first four cases in North America.

We report the first four North American cases of Candida dubliniensis fungemia, including the first isolation of this organism from the bloodstream of an HIV-infected person. All isolates were susceptible in vitro to commonly used antifungal drugs. This report demonstrates that C. dubliniensis can cause bloodstream infection; however, the incidence of disease is not known

Mid-to-Late M Dwarfs Lack Jupiter Analogs

Cold Jovian planets play an important role in sculpting the dynamical environment in which inner terrestrial planets form. The core accretion model predicts that giant planets cannot form around low-mass M dwarfs, although this idea has been challenged by recent planet discoveries. Here, we investigate the occurrence rate of giant planets around low-mass (0.1-0.3M$_\odot$) M dwarfs. We monitor a volume-complete, inactive sample of 200 such stars located within 15 parsecs, collecting four high-resolution spectra of each M dwarf over six years and performing intensive follow-up monitoring of two candidate radial-velocity variables. We use TRES on the 1.5 m telescope at the Fred Lawrence Whipple Observatory and CHIRON on the Cerro Tololo Inter-American Observatory 1.5 m telescope for our primary campaign, and MAROON-X on Gemini North for high-precision follow-up. We place a 95%-confidence upper limit of 1.5% (68%-confidence limit of 0.57%) on the occurrence of $M_{\rm P}$sin$i >$1M$_{\rm J}$ giant planets out to the water snow line and provide additional constraints on the giant planet population as a function of $M_{\rm P}$sin$i$ and period. Beyond the snow line ($100$ K $< T_{\rm eq} < 150$ K), we place 95%-confidence upper limits of 1.5%, 1.7%, and 4.4% (68%-confidence limits of 0.58%, 0.66%, and 1.7%) for 3M$_{\rm J} < M_{\rm P}$sin$i < 10$M$_{\rm J}$, 0.8M$_{\rm J} < M_{\rm P}$sin$i < 3$M$_{\rm J}$, and 0.3M$_{\rm J} < M_{\rm P}$sin$i < 0.8$M$_{\rm J}$ giant planets; i.e., Jupiter analogs are rare around low-mass M dwarfs. In contrast, surveys of Sun-like stars have found that their giant planets are most common at these Jupiter-like instellations.Comment: Accepted for publication in AJ; 19 pages, 5 figures, 2 table

Performance of wheat varieties, Oklahoma - 1981

The Oklahoma Cooperative Extension Service periodically issues revisions to its publications. The most current edition is made available. For access to an earlier edition, if available for this title, please contact the Oklahoma State University Library Archives by email at [email protected] or by phone at 405-744-6311

Ledger Combiners for Fast Settlement

Blockchain protocols based on variations of the longest-chain rule—whether following the proof-of-work paradigm or one of its alternatives—suffer from a fundamental latency barrier. This arises from the need to collect a sufficient number of blocks on top of a transaction-bearing block to guarantee the transaction’s stability while limiting the rate at which blocks can be created in order to prevent security-threatening forks. Our main result is a black-box security-amplifying combiner based on parallel composition of $m$ blockchains that achieves $\Theta(m)$-fold security amplification for conflict-free transactions or, equivalently, $\Theta(m)$-fold reduction in latency. Our construction breaks the latency barrier to achieve, for the first time, a ledger based purely on Nakamoto longest-chain consensus guaranteeing worst-case constant-time settlement for conflict-free transactions: settlement can be accelerated to a constant multiple of block propagation time with negligible error. Operationally, our construction shows how to view any family of blockchains as a unified, virtual ledger without requiring any coordination among the chains or any new protocol metadata. Users of the system have the option to inject a transaction into a single constituent blockchain or—if they desire accelerated settlement—all of the constituent blockchains. Our presentation and proofs introduce a new formalism for reasoning about blockchains, the dynamic ledger, and articulate our constructions as transformations of dynamic ledgers that amplify security. We also illustrate the versatility of this formalism by presenting robust-combiner constructions for blockchains that can protect against complete adversarial control of a minority of a family of blockchains

Photochemical disruption of endocytic vesicles before delivery of drugs: a new strategy for cancer therapy

The development of methods for specific delivery of drugs is an important issue for many cancer therapy approaches. Most of macromolecular drugs are taken into the cell through endocytosis and, being unable to escape from endocytic vesicles, eventually are degraded there, which hinders their therapeutic usefulness. We have developed a method, called photochemical internalization, based on light-induced photochemical reactions, disrupting endocytic vesicles specifically within illuminated sites e.g. tumours. Here we present a new drug delivery concept based on photochemical internalization-principle – photochemical disruption of endocytic vesicles before delivery of macromolecules, leading to an instant endosomal release instead of detrimental stay of the molecules in endocytic vesicles. Previously we have shown that illumination applied after the treatment with macromolecules substantially improved their biological effect both in vitro and in vivo. Here we demonstrate that exposure to light before delivery of protein toxin gelonin improves gelonin effect in vitro much more than light after. However, in vitro transfection with reporter genes delivered by non-viral and adenoviral vectors is increased more than 10- and six-fold, respectively, by both photochemical internalization strategies. The possible cellular mechanisms involved, and the potential of this new method for practical application of photochemical internalization concept in cancer therapy are discussed