Recurrent cutaneous leiomyosarcoma of the inner thigh

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Phototherapy and tailored brushing method. Personalized oral care in patients with facial and dental trauma. A report of a case

Abstract: (1) Background: Traumatic dental injuries are frequent in children and young adults. The facial structures involved in dental trauma may include soft tissues of the face and mouth, bone and dental structures. Dental trauma often results in augmented dental anxiety. Phototherapy can improve stress and pain control thereby improving compliance in young patients with the necessary dental treatments, after dental trauma has occurred. (2) Methods: Phototherapy was performed to enable soft tissue healing. The Tailored Brushing Method (TBM), a personalized approach for at-home oral hygiene procedures, was also utilized, with the aim of improving biofilm control in traumatized patients. (3) Results: The approach hereafter presented made it possible to obtain subjective control of anxiety and pain documented on a visual analog scale (VAS) due to the innovative use of photobiomodulation. In addition, for the first time, the TBM was adapted to the needs of a patient with facial trauma and illustrated. (4) Conclusions: Phototherapy and TBM were found to be effective in the combined treatment of soft tissue wounds and in the oral care of the traumatized patien

Resonance frequency evaluation on immediate loading implants with angled abutments: case series

Aim: Immediate loading of implant-supported prosthesis is a predictable and standardised therapy for rehabilitation of partially and totally edentulous patients. The present case series evaluate implant success rates by measuring resonance frequency on immediate loading implants with angled abutments. Materials and Methods: A prospective study was performed on five partially edentulous patients. Twenty-six Neoss ProActive Tapered® (Neoss Ltd. Harrogate, UK) implants were inserted: 22 in the maxillary bone and 4 in the mandibular bone. The Osstell ISQ® (Osstell; Integration Diagnostics, Göteborg, Sweden) was used to evaluate implant stability. Implant Stability Quotient (ISQ) measurements were performed in three stages: at time of implant insertion (t0), after three (t1) and 12 (t2) months. The ISQ values were recorded after implant installation of Access® (Neoss Ltd. Harrogate, UK) during the different stages. Results: A six months follow-up showed implant survival of 96%. Twenty-four implants were osseointegrated, a maxillary implant was lost and one other implant was excluded from the study. The values of ISQ ranged between 53-88 ISQ (average 66 ± 6.1 ISQ, median 67 ISQ) at t0, 51-80 ISQ (average 70 ± 5.8 ISQ, median 70 ISQ) at t1 and 53-80 ISQ (average 70.8 ± 5.7 ISQ, median 72 ISQ) at t2. Conclusions: The 24 out of 25 successful implants in five patients demonstrate how using 4-6 implants guarantees sufficient anchorage for a fixed prosthesis and adequate distribution of the prosthetic load on the maxillary and mandible bones, without causing implants failures

Clinical follow-up of atrial-fibrillation patients treated with novel oral anti-coagulants: A multi-disciplinary consensus from the Apulia section of the Italian Association of Hospital Cardiologists (ANMCO)

The clinical use of novel oral anti-coagulant (NOAC) drugs is actually regulated in Italy by bureaucratic restrictions; clinical prescription of NOACs preliminarily requires an online prescription plan which should be compiled on the Italian Drug Agency website. The prescription plan has 1-year validity and clinical condition of the patient treated with NOACs should be reassessed at 1-year prescription renewal. Only few specialists are presently allowed to prescribe NOACs: cardiologists, geriatricians, neurologists, hematologists and internists; general practitioners (GPs) are not currently allowed to prescribe NOACs, although they are the most in proximity with the patient. An even more complex issue is the pertinence of clinical follow-up of patients prescribed with NOACs (control of possible interactions with any new drug, periodical assessment of renal function, management of dose assumption mistakes or drug suspension for occurring surgery before hospitalization for any planned intervention). International statements partially indicate when and how periodical laboratory and clinical follow-up should be performed, but such statements do not often comply with local regulations and do not always take in due consideration the local criticalities and prescription limitations. In May 2015, the regional section of the Italian Association of Hospital Cardiologists of Apulia (ANMCO) therefore convened local representative champions of medical professionals potentially involved in prescription of NOACs, clinical management and follow-up of patients prescribed with NOACs. A final consensus conference formulated a possible shared diagnostic and therapeutic pathway for the clinical management and follow-up of patients assuming NOACs for atrial fibrillation

Rhinocerebral mucormycosis with orosinusal involvement: Diagnostic and surgical treatment guidelines

Background: Rhinocerebral mucormycosis is a rare, rapidly progressive and potentially lethal disease almost exclusively affecting immunocompromised hosts or patients with metabolic disorders, such as poorly controlled diabetes mellitus. Methods: This work is aimed to describe five cases of rhinocerebral mucormycosis to review and possibly define diagnostic and surgical treatment guidelines. In all the patients, surgical debridement, systemic and local antifungal therapy, and oral rehabilitation using filling prostheses were performed. Results: None of the patients revealed recurrence of the infection, as confirmed by radiological and clinical long term follow up. Conclusion: Given the lethal nature of the disease, the authors underline the importance of early diagnosis and of a multidisciplinary approach in order to undertake correct surgical and medical treatments, while keeping the underlying disease under control

The TRIMAGE PET Data Acquisition System: Initial Results

We present the first results obtained with a prototype of the PET read-out electronics of the trimodal PET/MRI/EEG TRIMAGE scanner. The read-out is based on the 64-channel TRIROC ASIC and on an acquisition board that will control up to 12 ASICs. The output of each ASIC is processed in parallel and sent to a host system that in the final version will receive data from 18 acquisition boards. Blocks of 64 SiPMs are one-to-one coupled to a dual-layer staggered LYSO crystal matrix and read by a single ASIC. The FPGA reads the sparse output from the ASICs and reconstructs for each event a full image of the light pattern coming from the LYSO matrix. This pattern can be then processed on-line or sent to the host PC for post-processing. Early tests were conducted by using a prototype board with single LYSO crystals of 3.3mm×3.3mm×8mm and dual layer staggered LYSO matrices. Results show that the ASIC can sustain input rates above 58 kHz on all its channels, with small variations depending on the discriminating thresholds, being this limit due its digital output stage. With the single crystals setup, we obtained an energy resolution of 10.7% at 511 keV and a coincidence time resolution of 420 ps FWHM. With the staggered matrix the obtained mean energy resolution was 16% on the top layer and 18% on the bottom layer. The flood maps obtained with the LYSO matrix setup show that the pixels on both the staggered levels are clearly identifiable

Prefrontal Co-Expression of miR-137 Target Genes is Related With Prefrontal Activity During Emotion Recognition

Schizophrenia risk is associated with multiple genes. Co-expression is a possible mechanism mediating the orchestrated contribution of these genes to risk. As key regulators of co-expression, miRNAs with a proven involvement in Schizophrenia such as miRNA-137 can be nodes of convergence of risk on the disorder system-level phenotypes. We hypothesized that miRNA-137 target genes converge in a co-expression pathway associated with Schizophrenia risk and that co-expression of these genes is linked with system-level phenotypes previously related with miRNA-137