Glucocorticoid pharmacogenetics in pediatric idiopathic nephrotic syndrome

Idiopathic nephrotic syndrome represents the most common type of primary glomerular disease in children: glucocorticoids (GCs) are the first-line therapy, even if considerable interindividual differences in thepir efficacy and side effects have been reported. Immunosuppressive and anti-inflammatory effects of these drugs are mainly due to the GC-mediated transcription regulation of pro- and anti-inflammatory genes. This mechanism of action is the result of a complex multistep pathway that involves the glucocorticoid receptor and several other proteins, encoded by polymorphic genes. Aim of this review is to highlight the current knowledge on genetic variants that could affect GC response, particularly focusing on children with idiopathic nephrotic syndrome

Ammonii Hermeae In libros Aristotelis de interpretatione commentarii / Bartholomaeo Syluanio ... interprete ; cum indice, quo omnia quae in hoc libro notatu digna sunt, locupletissime exponuntur.

ColofónSign.: A-E8, A-R8Indice a dos col.Capitulares grab. xil.Marca tip. en port. (Edit 16, U254

Ammonii Hermeae In praedicamenta Aristotelis commentarii / per Bartholomaeum Syluanium Salonensem nuper latine conuersi.

Marca tip. en port. (Edit 16, U254)Sign.: A-P8Error de fol., pasa de h. 119 a 118Hojas imp. por ambas carasIl. xil.Capitulares grab. xil

Effects of sulfide concentration, pH, and anoxia on photosynthesis and respiration of Zostera marina

Sulfide produced in marine sediments by sulfate reduction is toxic for several macrophytes, and high sediment sulfide concentrations have been associated with seagrass die-off events. Sulfide has been shown to reduce growth in a number of seagrasses, but little is known about its effect on the photosynthetic and respiratory metabolism. Consequently, the aim of this research was to evaluate the effect of sulfide on photosynthesis and respiration of the seagrass Zostera marina. Photosynthetic oxygen evolution and respiration were determined polarographically, while the optimum quantum yield was used as a measure of the photosynthetic performance of photosystem II in the leaves of Z. marina. The results showed that sulfide concentrations of approximately 1000 uM could be considered an upper threshold limit for the survival of Z. marina in the coastal lagoons of Baja California (Mexico) studied. Respiration was not inhibited by sulfide concentrations up to 1000 ?M during 48-h incubations, while photosynthetic performance was reduced by short exposure to sulfide concentrations of 25 uM but also by long exposure to concentrations as low as 50 uM. This is the first study that shows that the photosynthetic capacity of Z. marina is not recovered once the sulfide-free conditions have been re-established

Ammonii Hermeae In V. Porphyrii voces commentarii / per Ioannem Baptistam Rasarium latinitate donati.

Marca tip. en port. (Edit 16, U254)Sign.: A-G8, H4Hojas imp. por ambas carasCapitulares grab. xil

Psalterium decem cordarum Abbatis Ioachim

Pie de imp. tomado del colofónColofón de la 1. parte en 2E8, fechado en die vero septimo Februarij y de la 2. parte en die XVIII, mensis Martii, ambos sin la mención de los ed.Sign.: A4, 2a-2c8, 2d4, A-Z8, 2A-2N8, 2O4Port. a dos tintas con orla xil. y esc. cardenalicioCapitulares grab. xil.Il. xil.Cada parte con portadilla propiaTexto e índice a dos col., con apostillas marginalesHojas imp. por ambas caras