Reactive Crisis Management Model

Crisis is an ever present threat to an organization in our society. When a crisis occurs, an organization must act immediately to protect its reputation. There is a need of wide range study of crisis management. Various models regarding crisis management have been presented by various experts. These models are mainly proactive in nature having (1) Pre Crisis phase (2) Crisis phase (3) Post Crisis phase. Crisis management is a situation-based management system that includes clear roles and responsibilities and process related organizational requirements company-wide. As we know, crisis is an uncertain event, so preparing in advance for it is probably not possible. Even in diffusion of innovation theory it is discussed that during crisis, every employee should think out of the box and come up with novel ideas to overcome hard times. In this article, an attempt has been made to prepare a reactive crisis model which suggests a way to deal with crisis at the time it occurs. In this model, the crisis management protocol should follow three steps, namely, (1) GET (2) SET (3) GO. In first step, basic information regarding the crisis should be gathered viz, cause and severity of crisis. In second step, crisis management plans and teams should be formulated keeping in view the severity of crisis and the third step should deal with the execution of formulated plans with the help of crisis management team

Functionalized Nitroimidazole Scaffold Construction and Their Pharmaceutical Applications: A 1950–2021 Comprehensive Overview

Nitroimidazole represents one of the most essential and unique scaffolds in drug discovery since its discovery in the 1950s. It was K. Maeda in Japan who reported in 1953 the first nitroimidazole as a natural product from Nocardia mesenterica with antibacterial activity, which was later identified as Azomycin 1 (2-nitroimidazole) and remained in focus until now. This natural antibiotic was the starting point for synthesizing numerous analogs and regio-isomers, leading to several life-saving drugs and clinical candidates against a number of diseases, including infections (bacterial, viral, parasitic) and cancers, as well as imaging agents in medicine/diagnosis. In the present decade, the nitroimidazole scaffold has again been given two life-saving drugs (Delamanid and Pretomanid) used to treat MDR (multi-drug resistant) tuberculosis. Keeping in view the highly successful track-record of the nitroimidazole scaffold in providing breakthrough therapeutic drugs, this comprehensive review focuses explicitly on presenting the activity profile and synthetic chemistry of functionalized nitroimidazole (2-, 4- and 5-nitroimidazoles as well as the fused nitroimidazoles) based drugs and leads published from 1950 to 2021. The present review also presents the miscellaneous examples in each class. In addition, the mutagenic profile of nitroimidazole-based drugs and leads and derivatives is also discussed

Iron oxide mediated direct C–H arylation/alkylation at α-position of cyclic aliphatic ethers

We report a new and efficient iron oxide catalyzed crosscoupling reaction between organometallic species such as alkyl/arylmagnesium halides or organolithium species and a-hydrogen bearing cyclic aliphatic ethers via activation of C(sp3)–H. This is the first example of iron oxide mediated direct C–C bond formation without expensive or toxic ligands

Catalytic transfer hydrogenation reactions of PEG-bound succinyl esters

Various substrates bound to polyethylene glycol (PEG) through succinyl ester linkages were cleaved under catalytic transfer hydrogenation conditions. The substrates with unsaturated functions also underwent hydrogenation. The protocol was found to be suitable for substrates having acid and base labile functional groups

Domino synthesis of indenols and alkyl-indene ethers under modified Vilsmeier conditions

Indenols are produced in high yields through domino reactions, when electron-rich trans-stilbenes and other trans aryl–alkyl olefins were subjected to Vilsmeier formylation in the presence of excess POCl3 in a one-pot procedure. The method is even suitable for converting aryl–alkyl carbinols (precursors for olefins) directly into indenols. The corresponding indene ethers could be prepared in high yields directly when less reactive a,b-unsaturated aldehydes were subjected to cyclization in alcoholic HCl

Reaction of allenylmagnesium and allenylindium bromides with nitrile oxides: synthesis of novel 5-butynyl- and 5-methylisoxazoles

5-Butynylisoxazoles were obtained in high yields through a domino addition, C–O heterocyclization involving allenylmagnesium bromide and benzonitrile oxide in dry THF, in which the corresponding 5-methylisoxazoles were isolated in trace amounts. However, when the reactions were attempted in aqueous media using allenylindium bromide, 5-methylisoxazoles were formed as the sole products in high yields

Present drug-likeness filters in medicinal chemistry during the hit and lead optimization process: how far can they be simplified?

During the past decade, decreasing the attrition rate of drug development candidates reaching the market has become one of the major challenges in pharmaceutical research and drug development (R&D). To facilitate the decision-making process, and to increase the probability of rapidly finding and developing high-quality compounds, a variety of multiparametric guidelines, also known as rules and ligand efficiency (LE) metrics, have been developed. However, what are the 'best' descriptors and how far can we simplify these drug-likeness prediction tools in terms of the numerous, complex properties that they relate to?info:eu-repo/semantics/publishedVersio

Kinase Inhibitors of Marine Origin

Kinase Inhibitors of Marine Origi