Prandtl Number Effect on Assisted Convective Heat Transfer through a Solar Collector

Numerical study of the influence of Prandtl number on forced convective heat transfer through a riser pipe of a flat plate solar collector is done. The working fluid is Al2O3/water nanofluid. By Finite Element Method the governing partial differential equations are solved. The effect of the Prandtl number on the temperature and velocity field has been depicted. Comprehensive average Nusselt number, average bulk temperature, mean velocity, mid-height temperature inside the pipe, mean output temperature and collector efficiency are presented for the governing parameter mentioned above. Nu increases by 16% with the variation of Pr from 4.6 to 6.6 using nanofluid. Due to rising Pr heat transfer rate increases but collector efficiency devalues

Effect of Solid Volume Fraction on Forced Convective Flow of Nanofluid through Direct Absorption Solar Collector

The present work numerically investigates the heat transfer performance and entropy generation of forced convection through a direct absorption solar collector. The working fluid is Cu-water nanofluid. The simulations focus specifically on the effect of solid volume fraction of nanoparticle on the mean Nusselt number, total entropy generation, Bejan number and collector efficiency. Also Isotherms, heat function and entropy generation are presented for various solid volume fraction. The governing partial differential equations are solved using penalty finite element method with Galerkins weighted residual technique. The results show that the mean Nusselt number and mean entropy generation increases as the volume fraction of Cu nanoparticles increases. The results presented in this study provide a useful source of reference for enhancing the force convection heat transfer performance while simultaneously reducing the entropy generation

(R1496) Impact of Electronic States of Conical Shape of Indium Arsenide/Gallium Arsenide Semiconductor Quantum Dots

Semiconductor quantum dots (QDs) have unique atom-like properties. In this work, the electronic states of quantum dot grown on a GaAs substrate has been studied. The analytical expressions of electron wave function for cone-like quantum dot on the semiconductor surface has been obtained and the governing eigen value equation has been solved, thereby obtaining the dependence of ground state energy on radius and height of the cone-shaped -dots. In addition, the energy of eigenvalues is computed for various length and thickness of the wetting layer (WL). We discovered that the eigen functions and energies are nearly associated with the GaAs potential

Development of an Efficient in Vitro Regeneration System for Endangered Wild Orange Citrus Chrysocarpa L.

A method for in-vitro propagation of wild type Indian orange (Citrus chrysocarpa L.) was developed by shoot organogenesis from seed. Mature seed embryos were used as explants and treated with different hormones and plant growth regulators on MS medium for callus, shoots and roots induction. For callus inductio

Telomere length is associated with growth in children in rural Bangladesh

Background: Previously, we demonstrated that a water, sanitation, handwashing, and nutritional intervention improved linear growth and was unexpectedly associated with shortened childhood telomere length (TL) (Lin et al., 2017). Here, we assessed the association between TL and growth. Methods: We measured relative TL in whole blood from 713 children. We reported differences between the 10th percentile and 90th percentile of TL or change in TL distribution using generalized additive models, adjusted for potential confounders. Results: In cross-sectional analyses, long TL was associated with a higher length-for-age Z score at age 1 year (0.23 SD adjusted difference in length-for-age Z score (95% CI 0.05, 0.42; FDR-corrected p-value = 0.01)). TL was not associated with other outcomes. Conclusions: Consistent with the metabolic telomere attrition hypothesis, our previous trial findings support an adaptive role for telomere attrition, whereby active TL regulation is employed as a strategy to address ‘emergency states’ with increased energy requirements such as rapid growth during the first year of life. Although short periods of active telomere attrition may be essential to promote growth, this study suggests that a longer overall initial TL setting in the first two years of life could signal increased resilience against future telomere erosion events and healthy growth trajectories

Lmo2 expression defines tumor cell identity during T-cell leukemogenesis

The impact of LMO2 expression on cell lineage decisions during T-cell leukemogenesis remains largely elusive. Using genetic lineage tracing, we have explored the potential of LMO2 in dictating a T-cell malignant phenotype. We first initiated LMO2 expression in hematopoietic stem/progenitor cells and maintained its expression in all hematopoietic cells. These mice develop exclusively aggressive human-like T-ALL. In order to uncover a potential exclusive reprogramming effect of LMO2 in murine hematopoietic stem/progenitor cells, we next showed that transient LMO2 expression is sufficient for oncogenic function and induction of T-ALL. The resulting T-ALLs lacked LMO2 and its target-gene expression, and histologically, transcriptionally, and genetically similar to human LMO2-driven T-ALL. We next found that during T-ALL development, secondary genomic alterations take place within the thymus. However, the permissiveness for development of T-ALL seems to be associated with wider windows of differentiation than previously appreciated. Restricted Cre-mediated activation of Lmo2 at different stages of B-cell development induces systematically and unexpectedly T-ALL that closely resembled those of their natural counterparts. Together, these results provide a novel paradigm for the generation of tumor T cells through reprogramming in vivo and could be relevant to improve the response of T-ALL to current therapies.J.H. has been supported by the German Cancer Aid (Project 110997 and Translational Oncology Program 70112951), the German Jose Carreras Leukemia Foundation (DJCLS 02R/2016), Deutsches Konsortium für Translationale Krebsforschung (DKTK), Joint funding (Targeting MYC L*10), the Kinderkrebsstiftung (2016/17), and the “Elterninitiative Kinderkrebsklinik e.V. Düsseldorf”. SG has been supported by a scholarship of the Hochschule Bonn-Rhein-Sieg. AB has been supported by the German Children's Cancer Foundation and the Federal Ministry of Education and Research, Bonn, Germany. Research in ISG group is partially supported by FEDER and by MINECO (SAF2012-32810, SAF2015-64420-R, and Red de Excelencia Consolider OncoBIO SAF2014-57791-REDC), Instituto de Salud Carlos III (PIE14/00066), ISCIII- Plan de Ayudas IBSAL 2015 Proyectos Integrados (IBY15/00003), by Junta de Castilla y León (BIO/SA51/15, CSI001U14, UIC-017, and CSI001U16), Fundacion Inocente Inocente, and by the ARIMMORA project (European Union's Seventh Framework Programme (FP7/2007-2013) under grant agreement no. 282891). ISG Lab is a member of the EuroSyStem and the DECIDE Network funded by the European Union under the FP7 program. AB and ISG have been supported by the German Carreras Foundation (DJCLS R13/26). IGR was supported by BES-Ministerio de Economía y Competitividad (BES-2013-063789). AML and GRH were supported by FSE-Conserjería de Educación de la Junta de Castilla y León (CSI001-13, CSI001-15). Research in CVD group is partially supported by FEDER, “Miguel Servet” Grant (CP14/00082—AES 2013-2016) from the Instituto de Salud Carlos III (Ministerio de Economía y Competitividad), “Fondo de Investigaciones Sanitarias/Instituto de Salud Carlos III” (PI17/00167), and by the Lady Tata International Award for Research in Leukaemia 2016–2017

A Novel Role of LMO2 in DNA Repair Control in Diffuse Large B-Cell Lymphoma

LMO2 serves as one of the best prognostic markers for longer survival of diffuse large B cell lymphoma (DLBCL) patients. However, little it is known about its molecular function in normal B cells and DLBCL cells. Our study reveals a novel role for LMO2 in the control of DNA repair. We found that LMO2 inhibits the homologous recombination repair pathway, an essential mechanism for the repair of DNA double-strand breaks (DSB). The lack of activity of the homologous recombination pathway causes an accumulation of DSB in LMO2 expressing B cells, thus providing explanation for increased chemo-sensitivity of LMO2+ DLBCL tumors and the improved survival rates observed in patients with these tumors. Furthermore, based on our studies, here we propose a new treatment for LMO2-expressing DLBCL based on the observed DNA repair deficiency using Poly (ADP-ribose) polymerase (PARP) inhibitor-mediated synthetic lethality approach.</p