AN ACETOXYGENATED ANALOGUE OF ERGOSTEROL FROM A SOFT CORAL OF THE GENUS LOBOPHYTUM

Chemical investigation of a soft coral of the genus Lobophytum of Andaman and Nicobar coasts resulted in the isolation of a new marine sterol acetate, (24S)-ergostane-3β,5α,6β,25-tetraol-3,6,25-triacetate (1) and of two known sterol glycosides 3β,4α-dihydroxypregn-20-ene-4-O-β-D-arabinopyranoside and 24-methylenecholest-5-ene-3β,7β,16β-triol-3-O-α-L-fucopyranoside-7β-acetate. The structures of the compounds were elucidated based on spectral studies and chemical conversions

Phytochemical analysis and antimicrobial evaluation of chloroform extracts of stem and roots of Scoparia dulcis L.

206-211Natural compounds derived from medicinal plants serve as safe alternatives than conventional drugs in the treatment of various ailments, particularly microbial infections marred by antibiotic resistance. In this context, we screened the common Liquorice weed, Scoparia dulcis L. for phytochemicals and antimicrobial potential. Phytochemical and HPTLC analysis of chloroform extracts of stem and roots of S. dulcis showed the presence of diversity of secondary metabolites. The extracts of the plant were assayed for antimicrobial activity in vitro against selected pathogenic bacteria and fungi. The results have shown the plant extracts to possess antibacterial and antifungal activities. The highest antibacterial activity exhibited by chloroform extract of the stem was against Staphylococcus aureus and roots against Escherichia coli. The minimum inhibitory concentrations of stem and roots chloroform extracts (MIC, 150, 75 mg/mL of each) showed highest antibacterial and antifungal activities against E. coli and Asperigillus niger

HYPOTHYROIDISM AND ALTERATIONS IN HAEMATOLOGICAL PARAMETERS : Hypothyroidism

Objective: The goal of the current study was to determine how hypothyroidism affected several hematological markers. Patients and methods: This prospective observational study involved 200 participants in total. They are enrolled and split into two groups, each of which has 100 participants.. The first group consists of 100 cases of Hypothyroidism, whose Blood cell indices are compared with 100 healthy individuals as a control in the second group. Patients with Diabetes Mellitus, Hyperthyroidism, Congenital Thyroid disorders, Thyroid malignancies, Hemolytic Anemias, Aplastic Anemia, Malignancies, Leukemias and Blood Dyscrasias were excluded. Results: The study discovered a statistically significant difference in haemoglobin (Hb), RBC count (RBC), hematocrit (HCT), mean corpuscular volume (MCV), mean corpuscular haemoglobin (MCH), mean corpuscular haemoglobin concentration (MCHC), and red cell distribution width (RDW), with P values of 0.000, 0.000, 0.000, 0.002, 0.000, and 0.022, respectively. Platelets and WBC showed no (P value 0.410 and 0.6420). Conclusion: Except for RDW levels, which are high among them, the majority of the haematological markers in hypothyroid subjects in this study are significantly low. Platelet count and WBC are less affected in cases when compared with the controls, and the study indicates that anaemia is associated with hypothyroidism. Before starting on iron therapy or any other treatments, patients with anaemia who have thyroid dysfunction should also have a complete blood count performed as part of their follow-up care

Chemical examination of the Echinoderms of Indian Ocean: The triterpene glycos ides of the sea cucumbers: <i>Holothuria nobilis, Bohadschia aff. tenuissima </i>and <i>Actinopyga mauritana </i>from Lakshadweep, Andaman and Nicobar Islands

1276-1282The ethanol extracts of the sea cucumbers Holothuria nobilis, Bohadschia aff. tenuissima and Actinopyga mauritana furnishes three distinct fractions; a mixture of sterol glycosides, a mixture of cerebrosides and a mixture of triterpenoid glycosides identified as holothurin B, bivittosides C and D and echinoside B, respectively, from a comparison of the 1H NMR and 13C NMR spectral data reported earlier. Hydrolysis of triterpenoid glycosides yield three new artificial genins (1,1a and 2) along with seven known genins (3-9). The structures of these new genins have been determined by their physical and spectral data (UV, [α]D, 1H NMR and mass)