Objective: The goal of the current study was to determine how hypothyroidism affected several hematological markers. Patients and methods: This prospective observational study involved 200 participants in total. They are enrolled and split into two groups, each of which has 100 participants.. The first group consists of 100 cases of Hypothyroidism, whose Blood cell indices are compared with 100 healthy individuals as a control in the second group. Patients with Diabetes Mellitus, Hyperthyroidism, Congenital Thyroid disorders, Thyroid malignancies, Hemolytic Anemias, Aplastic Anemia, Malignancies, Leukemias and Blood Dyscrasias were excluded. Results: The study discovered a statistically significant difference in haemoglobin (Hb), RBC count (RBC), hematocrit (HCT), mean corpuscular volume (MCV), mean corpuscular haemoglobin (MCH), mean corpuscular haemoglobin concentration (MCHC), and red cell distribution width (RDW), with P values of 0.000, 0.000, 0.000, 0.002, 0.000, and 0.022, respectively. Platelets and WBC showed no (P value 0.410 and 0.6420). Conclusion: Except for RDW levels, which are high among them, the majority of the haematological markers in hypothyroid subjects in this study are significantly low. Platelet count and WBC are less affected in cases when compared with the controls, and the study indicates that anaemia is associated with hypothyroidism. Before starting on iron therapy or any other treatments, patients with anaemia who have thyroid dysfunction should also have a complete blood count performed as part of their follow-up care
