Restoration of Altered MicroRNA Expression in the Ischemic Heart with Resveratrol

Resveratrol, a constituent of red wine, is important for cardioprotection. MicroRNAs are known regulators for genes involved in resveratrol-mediated cardiac remodeling and the regulatory pathway involving microRNA has not been studied so far.We explored the cardioprotection by resveratrol in ischemia/reperfusion model of rat and determined cardiac functions. miRNA profile was determined from isolated RNA using quantitative Real-time PCR based array. Systemic analyses of miRNA array and theirs targets were determined using a number of computational approaches.Cardioprotection by resveratrol and its derivative in ischemia/reperfusion [I/R] rat model was examined with miRNA expression profile. Unique expression pattern were found for each sample, particularly with resveratrol [pure compound] and longevinex [commercial resveratrol formulation] pretreated hearts. Longevinex and resveratrol pretreatment modulates the expression pattern of miRNAs close to the control level based on PCA analyses. Differential expression was observed in over 25 miRNAs, some of them, such as miR-21 were previously implicated in cardiac remodeling. The target genes for the differentially expressed miRNA include genes of various molecular function such as metal ion binding, sodium-potassium ion, transcription factors, which may play key role in reducing I/R injury.Rats pretreated with resveratrol for 3 weeks leads to significant cardioprotection against ischemia/reperfusion injury. A unique signature of miRNA profile is observed in control heart pretreated with resveratrol or longevinex. We have determined specific group of miRNA in heart that have altered during IR injuries. Most of those altered microRNA expressions modulated close to their basal level in resveratrol or longevinex treated I/R mice

Report from a symposium on catalyzing primary and secondary prevention of cancer in India

PurposeOral, breast, and cervical cancers are amenable to early detection and account for a third of India’s cancer burden. We convened a symposium of diverse stakeholders to identify gaps in evidence, policy, and advocacy for the primary and secondary prevention of these cancers and recommendations to accelerate these efforts. MethodsIndian and global experts from government, academia, private sector (health care, media), donor organizations, and civil society (including cancer survivors and patient advocates) presented and discussed challenges and solutions related to strategic communication and implementation of prevention, early detection, and treatment linkages.ResultsInnovative approaches to implementing and scaling up primary and secondary prevention were discussed using examples from India and elsewhere in the world. Participants also reflected on existing global guidelines and national cancer prevention policies and experiences.ConclusionsSymposium participants proposed implementation-focused research, advocacy, and policy/program priorities to strengthen primary and secondary prevention efforts in India to address the burden of oral, breast, and cervical cancers and improve survival

Kick-starting a second green revolution in Bengal [India].

Two decisions taken by the Government of West Bengal, one, to facilitate easier extraction of groundwater, and the other, the application of a fixed connection fee for an electricity connection to farmers could well lead to a quantum leap in agricultural production

In Mukherjee, A. (Ed.). Groundwater of South Asia. Singapore: Springer

Private investments in groundwater have emerged as the main pathway through which smallholder farmers in India access irrigation. This paper discusses the role of groundwater in agrarian growth in West Bengal, India. It finds that agricultural growth in the state has stagnated since mid-1990s, after an initial period of growth in the 1980s and early 1990s. We hypothesize that this stagnation was a direct result of slowdown in growth in groundwater irrigation. The reason for this slowdown was, in turn, government policies related to groundwater and electricity. The paper then goes on to discuss the Groundwater Act of 2005 as well as electrification policies of the government of West Bengal and locates these policies within the broader backdrop of groundwater resource endowments in the state. By juxtaposing groundwater policies and resource realities, the paper questions the relevance of current regulations and suggests some policy alternatives - alternatives that are likely to propel the state and its smallholder farmers on a path of higher agricultural growth

Managing the energy-irrigation nexus in west Bengal, India

In Mukherji, Aditi; Villholth, K. G.; Sharma, Bharat R.; Wang, J. (Eds.) Groundwater governance in the Indo-Gangetic and Yellow River basins: realities and challenges. London, UK: CRC PressIAH Selected Papers on Hydrogeology 1