DEVELOPMENT AND VALIDATION OF STABILITY INDICATING HPTLC METHOD FOR ESTIMATION OF SWERTIAMARIN IN BULK AND DOSAGE FORM

Objective: In the present study a novel stability-indicating high-performance thin-layer chromatography (HPTLC) method for quantitative determination of Swertiamarin (SW) in bulk drug and formulation has been developed and validated as per ICH guideline Q2 (R1) for global acceptance of standardized herbal formulations. Methods: HPTLC method is developed and validated using solvent ethyl acetate: ethanol: chloroform (3:2.5:4.5 v/v/v) (Rf of SW 0.65±0.04) in the absorbance mode at 243 nm. Various forced degradation conditions were used to check degradation of drug. Results: The method showed a good linear relationship (r2 = 0.9990) in the concentration range 200-700 ng per spot. It was found to be linear, accurate, precise and specific. Conclusion: It can be applied for quality control as well as for stability testing of different dosage forms containing swertiamarin. The developed method is validated as per ICH guideline Q2(R1) for global acceptance of standardized herbal formulations

Knowledge and awareness about Iron deficiency and megaloblastic anaemia among blood donors: a study at rural based tertiary care hospital

Background: Voluntary blood donation is promoted in order to make the blood banking safe and successful. Research in the area of blood donation has found that, iron stores are influenced by regular blood donation if dietary intake of iron is inadequate. Awareness and knowledge among blood donors regarding iron and B12 deficiency and its prevention is very much required. Objective: To assess the knowledge and awareness about iron deficiency and megaloblastic anaemia among blood donors.  Methods: A cross sectional study was conducted among the 500 voluntary blood donors during the span of 1 year at one of the blood bank of tertiary care hospital  using prestructured questionnaire on the various aspect of iron and B12 deficiency/folate deficiency anemia. The data was analysed with the help of Microsoft excel and SPSS.Results: Out of 500 blood donors, 15.6% donors were regular blood donor. It was observed 60% blood donors were having knowledge of anemia in general. Iron deficiency and vitamin B12 deficiency were known to 42% and 31.6% donors, respectively. Only 20% donors could able to answer the acceptable level of hemoglobin require for donating the blood. About 42% donors were aware about importance of iron, folate and vitamin B12 in maintaining normal hemoglobin level. Majority (82.7%) of regular blood donors were willing to get information regarding iron, folate and vitamin B12 deficiency.Conclusion: Significant lack of awareness regarding iron and vitamin B12 deficiency was observed in regular voluntary blood donors. The present study recommends the provision of health education on iron and vitamin B12 deficiency as well as Iron, folate and vitamin B12 rich foods to regular blood donor to prevent anaemia among them.

Authorship pattern and growth of scholar contributions for PHFI: A Bibliometric Analysis

The purpose of this research study is to identify the authorship patterns and degree of collaboration and growth of Public health foundation of India in Public Health research related with a total of 1941 records of publications authored by 12523 authors during the period 2011– 2020 derived from SCOPUS database. Validation of determine chronological growth, authorship pattern, core sources for research communication, and encouragement of productivity by citations received, various indicators, and indices and bibliometric laws i.e. Authorship pattern, RGR, Dt, CAI, DC, Bradford’s Law of distributions, and more have been applied appropriately. Additionally, used deferent software of like ‘MS-Excel’ and ‘bibliometrix’ & ‘biblioshiny’ of R-Package software and VOSviwer software applied for detailed and reliable analysis. Evaluated data figured out Average yearly contribution 194 research however accounted Mean RGR(P) ‘0.34’; Mean Dt (P) ’2.74 reveals inconsistent growth of research output. Average of ‘Collaboration index’ (CI) ‘5.60’ A total Average yearly citations were received for research occurrence in the span with an average of 10.46, Prabhakaran. D., was published highest papers 260 and got received highest citation also 4958 and total link strength 1457. For PHFI and individual research scholars. PHFI has to make more effort to promote research and create quality culture, attention of developing better policies to enhance and enrich the research performance of individuals

Bibliometric study of SAARC Countries Research Trends in Public Health using Scopus database

Public health is facing a current covid-19 crisis situation in the world. This study aims to analyze particular the South Asian Association for Regional Cooperation (SAARC) countries\u27 public health research interest and growth. This bibliometric study selected the Public Health keyword from Scopus database geographical area selected was only SAARC countries in the title only and retrieved 1720 published articles. The time period selected was from 1957 to March 2021. 5758 authors were identified to published relevant studies on total over an average of 7.34 years in public health. The data retrieval most productive three main publishing countries India, Pakistan, and Bangladesh. Most productive institutions and authors are from India. Bibliometric analysis showed growth in international collaboration with the USA among most SAARC countries. The most productive journal was found to be “Indian Journal of Public Health” and the most productive author Ramasam, Y. J having a total of publication 57. This bibliometric analysis provides an inclusive overview of the public health research conducted in SAARC countries, which helps researchers, policy makers, and practitioner better understand the development of public health care and possible practice implications. Future Public health research should be dedicated to filling in the gaps between SAARC Countries health care research

A drug utilization study in glaucoma patients in ophthalmology out patient department in a tertiary care hospital

Background: According to World Health Organization (WHO) studies Glaucoma is a chronic progressive symptomatic disease that damages retinal cells and is one of the leading cause of preventable blindness worldwide. Availability of newer topical agents has modernized the management of glaucoma.Methods: A prospective observational study was carried out from August 2016 to December 2016 at ophthalmology Out Patient Department of L.G General Hospital, Ahmedabad by authours after the approval of the Institutional Ethics Committee.Results: Out of total 101 patients, 71 were males and 30 were females. Average age of patient is 54 years. Common variant of Glaucoma was Primary Open Angle Glaucoma in 57.4% of patients. Average number of drugs per prescription was 2 (45%). Most commonly used Fixed Dose Combination was Brimonidine +Timolol Drops which was used in 87 (86.1%) patients. Most commonly used adjuvant drug was Tab. Acetazolamide (60% of patients).Conclusions: Common variant of Glaucoma was Primary Open Angle Glaucoma in 57.4% of patients. Most commonly used Fixed Dose Combination was Brimonidine+Timolol Drops which was used in 87 (86.1%) patients and commonly used Single drug therapy is Tab. Acetazolamide in (60% of patients)

CONCEPTUAL MODIFICATION IN DYE AND DYE INTERMEDIATES: ACID BLACK

ABSTRACT Process modification consists of the development of novel apparatuses and techniques that compared to those commonly used today are expected to bring dramatic improvements in manufacturing and processing, substantially decreasing equipment-size/production-capacity ratio, energy consumption, or waste production, and ultimately resulting in cheaper, sustainable technologies. Any chemical engineering development that leads to a substantially smaller, cleaner and more energy efficient technology is process intensification. The objective of the paper is to Modify, Intensify and Energy Efficient process in dye manufacturing units in Gujarat. The focus of the study is to minimize wastes, to improve energy efficiency and improve the process practices/cycles to optimize resource utilization

In-vitro antioxidant and in-vivo anti-inflammatory activities of aerial parts of Cassia species

AbstractCassia species are native to Southeast Asia and sub-Saharan Africa and are commonly used as food and in a broad variety of medicinal applications. Cassia species are widely used in India, but there are few reports in the literature of studies on its chemical compositions and biological properties. In this study, the antioxidant and anti-inflammatory activities of two plants of Cassia species namely Cassia siamea (Lam.) and Cassia javanica (Linn.) were evaluated and the total phenolic compounds and flavonoid contents were determined.The antioxidant activity of the extracts was measured using scavenging of 2,2′-Diphenyl-1-picrylhydrazyl hydrate (DPPH), bleaching of β-carotene and % inhibition of H2O2. The anti-inflammatory activity was evaluated using carrageenan induced paw edema method on Wistar albino rats. The etahnolic extracts of aerial parts of C. siamea and C. javanica were evaluated for in vivo anti-inflammatory activity against the animal model of female Wistar albino rats. Ethanol extracts showed significant and dose-dependent anti-inflammatory effects. The contents of flavonoids and total phenolic compounds could be correlated with the antioxidant and anti-inflammatory activities observed for C. siamea and C. javanica. Our findings suggest that aerial parts of C. siamea and C. javanica contain potential antioxidant and anti-inflammatory compounds, which could be tested as drug candidates against oxidative and inflammation-related pathological processes in medicinal chemistry studies

Effects of Strong Magnetic Fields on Neutron Star Structure

We study static neutron stars with poloidal magnetic fields and a simple class of electric current distributions consistent with the requirement of stationarity. For this class of electric current distributions, we find that magnetic fields are too large for static configurations to exist when the magnetic force pushes a sufficient amount of mass off-center that the gravitational force points outward near the origin in the equatorial plane. (In our coordinates an outward gravitational force corresponds to $\partial\ln g_{tt}/\partial r>0$, where $t$ and $r$ are respectively time and radial coordinates and $g_{tt}$ is coefficient of $dt^2$ in the line element.) For the equations of state (EOSs) employed in previous work, we obtain configurations of higher mass than had been reported; we also present results with more recent EOSs. For all EOSs studied, we find that the maximum mass among these static configurations with magnetic fields is noticeably larger than the maximum mass attainable by uniform rotation, and that for fixed values of baryon number the maximum mass configurations are all characterized by an off-center density maximum.Comment: Submitted to the Astrophysical Journal. 37 pages, 8 figures, uses aastex macro

4U2206+54 - an Unusual High Mass X-ray Binary with a 9.6 Day Orbital Period but No Strong Pulsations

Rossi X-ray Timing Explorer All-Sky Monitor observations of the X-ray source 4U2206+54, previously proposed to be a Be star system, show the X-ray flux to be modulated with a period of approximately 9.6 days. If the modulation is due to orbital variability then this would be one of the shortest orbital periods known for a Be star X-ray source. However, the X-ray luminosity is relatively modest whereas a high luminosity would be predicted if the system contains a neutron star accreting from the denser inner regions of a Be star envelope. Although a 392s pulse period was previously reported from EXOSAT observations, a reexamination of the EXOSAT light curves does not show this or any other periodicity. An analysis of archival RXTE Proportional Counter Array observations also fails to show any X-ray pulsations. We consider possible models that may explain the properties of this source including a neutron star with accretion halted at the magnetosphere and an accreting white dwarf.Comment: Accepted for publication in the Astrophysical Journa