Research on optimization-based design

Research on optimization-based design is discussed. Illustrative examples are given for cases involving continuous optimization with discrete variables and optimization with tolerances. Approximation of computationally expensive and noisy functions, electromechanical actuator/control system design using decomposition and application of knowledge-based systems and optimization for the design of a valve anti-cavitation device are among the topics covered

Reconstructing thawing quintessence with multiple datasets

In this work we model the quintessence potential in a Taylor series expansion, up to second order, around the present-day value of the scalar field. The field is evolved in a thawing regime assuming zero initial velocity. We use the latest data from the Planck satellite, baryonic acoustic oscillations observations from the Sloan Digital Sky Survey, and Supernovae luminosity distance information from Union2.1 to constrain our models parameters, and also include perturbation growth data from the WiggleZ, BOSS and the 6dF surveys. The supernova data provide the strongest individual constraint on the potential parameters. We show that the growth data performance is competitive with the other datasets in constraining the dark energy parameters we introduce. We also conclude that the combined constraints we obtain for our model parameters, when compared to previous works of nearly a decade ago, have shown only modest improvement, even with new growth of structure data added to previously-existent types of data.Comment: 9 pages, 4 figures and 1 table. Version 2 with minor changes to match Physical Review D accepted versio

The WMAP normalization of inflationary cosmologies

We use the three-year WMAP observations to determine the normalization of the matter power spectrum in inflationary cosmologies. In this context, the quantity of interest is not the normalization marginalized over all parameters, but rather the normalization as a function of the inflationary parameters n and r with marginalization over the remaining cosmological parameters. We compute this normalization and provide an accurate fitting function. The statistical uncertainty in the normalization is 3 percent, roughly half that achieved by COBE. We use the k-l relation for the standard cosmological model to identify the pivot scale for the WMAP normalization. We also quote the inflationary energy scale corresponding to the WMAP normalization.Comment: 4 pages RevTex4 with two figure

Diisopropylamide and TMP turbo-grignard reagents : a structural rationale for their contrasting reactivities

A neutral dimeric molecule in crystal form, the diisopropylamido turbo-Grignard reagent "(iPr2N)MgCl⋅LiCl" (see structure; blue N, red O, green Mg, yellow Cl, black C) separates into several charged ate species in dynamic exchange with each other in THF solution as determined by a combination of EXSY and DOSY NMR studies

Bayesian analysis of Friedmannless cosmologies

Assuming only a homogeneous and isotropic universe and using both the 'Gold' Supernova Type Ia sample of Riess et al. and the results from the Supernova Legacy Survey, we calculate the Bayesian evidence of a range of different parameterizations of the deceleration parameter. We consider both spatially flat and curved models. Our results show that although there is strong evidence in the data for an accelerating universe, there is little evidence that the deceleration parameter varies with redshift.Comment: 7 pages, 3 figure

New directions in EEG measurement: an investigation into the fidelity of electrical potential sensor signals

Low frequency noise performance is the key indicator in determining the signal to noise ratio of a capacitively coupled sensor when used to acquire electroencephalogram signals. For this reason, a prototype Electric Potential Sensor device based on an auto-zero operational amplifier has been developed and evaluated. The absence of 1/f noise in these devices makes them ideal for use with signal frequencies ~10 Hz or less. The active electrodes are designed to be physically and electrically robust and chemically and biochemically inert. They are electrically insulated (anodized) and have diameters of 12 mm or 18 mm. In both cases, the sensors are housed in inert stainless steel machined housings with the electronics fabricated in surface mount components on a printed circuit board compatible with epoxy potting compounds. Potted sensors are designed to be immersed in alcohol for sterilization purposes. A comparative study was conducted with a commercial wet gel electrode system. These studies comprised measurements of both free running electroencephalogram and Event Related Potentials. Quality of the recorded electroencephalogram was assessed using three methods of inspection of raw signal, comparing signal to noise ratios, and Event Related Potentials noise analysis. A strictly comparable signal to noise ratio was observed and the overall conclusion from these comparative studies is that the noise performance of the new sensor is appropriate

Quantum spin chains of Temperley-Lieb type: periodic boundary conditions, spectral multiplicities and finite temperature

We determine the spectra of a class of quantum spin chains of Temperley-Lieb type by utilizing the concept of Temperley-Lieb equivalence with the S=1/2 XXZ chain as a reference system. We consider open boundary conditions and in particular periodic boundary conditions. For both types of boundaries the identification with XXZ spectra is performed within isomorphic representations of the underlying Temperley-Lieb algebra. For open boundaries the spectra of these models differ from the spectrum of the associated XXZ chain only in the multiplicities of the eigenvalues. The periodic case is rather different. Here we show how the spectrum is obtained sector-wise from the spectra of globally twisted XXZ chains. As a spin-off, we obtain a compact formula for the degeneracy of the momentum operator eigenvalues. Our representation theoretical results allow for the study of the thermodynamics by establishing a TL-equivalence at finite temperature and finite field.Comment: 29 pages, LaTeX, two references added, redundant figures remove

Challenges of ultra large scale integration of biomedical computing systems

The NCRI Informatics Initiative is overseeing the implementation of an informatics framework for the UK cancer research community. The framework advocates an integrated multidisciplinary method of working between scientific and medical communities. Key to this process is community adoption of high quality acquisition, storage, sharing and integration of diverse data elements to improve knowledge of the causes, prevention and treatment of cancer. The integration of the complex data and meta-data used by these multiple communities is a significant challenge and there are technical, resource-based and sociological issues to be addressed. In this paper we review progress aimed at establishing the framework and outline key challenges in ultra large scale integration of biomedical computing systems

Compressive Phase Contrast Tomography

When x-rays penetrate soft matter, their phase changes more rapidly than their amplitude. In- terference effects visible with high brightness sources creates higher contrast, edge enhanced images. When the object is piecewise smooth (made of big blocks of a few components), such higher con- trast datasets have a sparse solution. We apply basis pursuit solvers to improve SNR, remove ring artifacts, reduce the number of views and radiation dose from phase contrast datasets collected at the Hard X-Ray Micro Tomography Beamline at the Advanced Light Source. We report a GPU code for the most computationally intensive task, the gridding and inverse gridding algorithm (non uniform sampled Fourier transform).Comment: 5 pages, "Image Reconstruction from Incomplete Data VI" conference 7800, SPIE Optical Engineering + Applications 1-5 August 2010 San Diego, CA United State

Radio-quiet and radio-loud pulsars: similar in Gamma-rays but different in X-rays

We present new Chandra and XMM-Newton observations of a sample of eight radio-quiet Gamma-ray pulsars detected by the Fermi Large Area Telescope. For all eight pulsars we identify the X-ray counterpart, based on the X-ray source localization and the best position obtained from Gamma-ray pulsar timing. For PSR J2030+4415 we found evidence for an about 10 arcsec-long pulsar wind nebula. Our new results consolidate the work from Marelli et al. 2011 and confirm that, on average, the Gamma-ray--to--X-ray flux ratios (Fgamma/Fx) of radio-quiet pulsars are higher than for the radio-loud ones. Furthermore, while the Fgamma/Fx distribution features a single peak for the radio-quiet pulsars, the distribution is more dispersed for the radio-loud ones, possibly showing two peaks. We discuss possible implications of these different distributions based on current models for pulsar X-ray emission.Comment: Accepted for publication in The Astrophysical Journal; 12 pages, 3 figures, 2 table