16,193 research outputs found
More, More, More: Reducing Thrombosis in Acute Coronary Syndromes Beyond Dual Antiplatelet Therapy-Current Data and Future Directions.
© 2018 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley.Common to the pathogenesis of acute coronary syndromes (ACS) is the formation of arterial thrombus, which results from platelet activation and triggering of the coagulation cascade.1 To attenuate the risk of future thrombotic events, patients with ACS are treated with dual antiplatelet therapy (DAPT), namely, the combination of aspirin with a P2Y12 inhibitor, such as clopidogrel, ticagrelor, or prasugrel. Despite DAPT, some ≈10% of ACS patients experience recurrent major adverse cardiovascular events over the subsequent 30 days,2 driving the quest for more effective inhibition of thrombotic pathways. In this review, we provide an overview of studies to date and those ongoing that aim to deliver more effective combinations of antithrombotic agents to patients with recent ACS. We have chosen to confine the review to ACS patients without atrial fibrillation because those with atrial fibrillation have a clear indication for combination therapy that includes oral anticoagulation and should, we feel, be treated as a separate cohort. In this article, we discuss the limitations of the currently available clinical trial data and future directions, with suggestions for how practice might change to reduce the risk of coronary thrombosis in those at greatest risk, with minimal impact on bleeding.Peer reviewedFinal Published versio
Effect of microstructural evolution on magnetic property of Mn-implanted p-type GaN
The effect of microstructural evolution on magnetic property of Mn-implanted p-type GaN was discussed. The effect was studied using cross-sectional transmission electron microscopy (TEM). It was shown that the higher-temperature annealing reduced the ferromagnetic signal and produced antiferromagnetic Mn-nitride nanoclusters.open161
The estimation of neutrino fluxes produced by proton-proton collisions at TeV of the LHC
Intense and collimated neutrino beams are produced by charm and beauty
particle decays from proton-proton collisions at the LHC. A neutrino experiment
would be run parasitically without interrupting the LHC physics program during
the collider run. We estimate the neutrino fluxes from proton-proton collisions
at TeV of the LHC with the designed luminosity, 10^{34} \lumi.
By mounting about 200 tons of fiducial volume of a neutrino detector at 300
\m away from the interaction point, about 150,000 of charged current neutrino
events per year can be observable.Comment: 8 pages, Accepted in JHE
Internal transport barriers in the National Spherical Torus Experiment
In the National Spherical Torus Experiment [M. Ono , Nucl. Fusion 41, 1435 (2001)], internal transport barriers (ITBs) are observed in reversed (negative) shear discharges where diffusivities for electron and ion thermal channels and momentum are reduced. While neutral beam heating can produce ITBs in both electron and ion channels, high harmonic fast wave heating can also produce electron ITBs (e-ITBs) under reversed magnetic shear conditions without momentum input. Interestingly, the location of the e-ITB does not necessarily match that of the ion ITB (i-ITB). The e-ITB location correlates best with the magnetic shear minima location determined by motional Stark effect constrained equilibria, whereas the i-ITB location better correlates with the location of maximum ExB shearing rate. Measured electron temperature gradients in the e-ITB can exceed critical gradients for the onset of electron thermal gradient microinstabilities calculated by linear gyrokinetic codes. A high-k microwave scattering diagnostic shows locally reduced density fluctuations at wave numbers characteristic of electron turbulence for discharges with strongly negative magnetic shear versus weakly negative or positive magnetic shear. Reductions in fluctuation amplitude are found to be correlated with the local value of magnetic shear. These results are consistent with nonlinear gyrokinetic simulations predicting a reduction in electron turbulence under negative magnetic shear conditions despite exceeding critical gradients.X1128sciescopu
Strangeness in the nucleon and the ratio of proton-to-neutron neutrino-induced quasi-elastic yield
The electroweak form factors of the nucleon as obtained within a three flavor
pseudoscalar vector meson soliton model are employed to predict the ratio of
the proton and neutron yields from , which are induced by quasi-elastic
neutrino reactions. These predictions are found to vary only moderately in the
parameter space allowed by the model. The antineutrino flux of the up-coming
experiment determining this ratio was previously overestimated. The
corresponding correction is shown to have only a small effect on the predicted
ratio. However, it is found that the experimental result for the ratio
crucially depends on an accurate measurement of the energy of the knocked out
nucleon.Comment: 17 pages, LaTeX, 2 tables, 4 figures, Discussion on shape of strange
form factors added, Z. Phys. A, to be publishe
On the perturbative S-matrix of generalized sine-Gordon models
Motivated by its relation to the Pohlmeyer reduction of AdS_5 x S^5
superstring theory we continue the investigation of the generalized sine-Gordon
model defined by SO(N+1)/SO(N) gauged WZW theory with an integrable potential.
Extending our previous work (arXiv:0912.2958) we compute the one-loop
two-particle S-matrix for the elementary massive excitations. In the N = 2 case
corresponding to the complex sine-Gordon theory it agrees with the charge-one
sector of the quantum soliton S-matrix proposed in hep-th/9410140. In the case
of N > 2 when the gauge group SO(N) is non-abelian we find a curious anomaly in
the Yang-Baxter equation which we interpret as a gauge artifact related to the
fact that the scattered particles are not singlets under the residual global
subgroup of the gauge group
Quantum interference and Klein tunneling in graphene heterojunctions
The observation of quantum conductance oscillations in mesoscopic systems has
traditionally required the confinement of the carriers to a phase space of
reduced dimensionality. While electron optics such as lensing and focusing have
been demonstrated experimentally, building a collimated electron interferometer
in two unconfined dimensions has remained a challenge due to the difficulty of
creating electrostatic barriers that are sharp on the order of the electron
wavelength. Here, we report the observation of conductance oscillations in
extremely narrow graphene heterostructures where a resonant cavity is formed
between two electrostatically created bipolar junctions. Analysis of the
oscillations confirms that p-n junctions have a collimating effect on
ballistically transmitted carriers. The phase shift observed in the conductance
fringes at low magnetic fields is a signature of the perfect transmission of
carriers normally incident on the junctions and thus constitutes a direct
experimental observation of ``Klein Tunneling.''Comment: 13 pages and 6 figures including supplementary information. The paper
has been modified in light of new theoretical results available at
arXiv:0808.048
Comparative algological and bacteriological examinations on biofilms developed on different substrata in a shallow soda lake
According to the European Water Framework Directives, benthic diatoms of lakes are a tool for ecological status assessment. In this study, we followed an integrative sample analysis approach, in order to find an appropriate substratum for the water qualification-oriented biomonitoring of a shallow soda lake, Lake Velencei. Six types of substrata (five artificial and one natural), i.e., andesite, granite, polycarbonate, old reed stems, Plexiglass discs and green reed, were sampled in May and in November. We analysed total alga and diatom composition, chlorophyll a content of the periphyton, surface tension and roughness of the substrata and carbon source utilisation of microbial communities. Water quality index was calculated based on diatom composition. Moreover, using a novel statistical tool, a self-organising map, we related algal composition to substratum types. Biofilms on plastic substrates deviated to a great extent from the stone and reed substrata, with regard to the parameters measured, whereas the biofilms developing on reed and stone substrata were quite similar. We conclude that for water quality monitoring purposes, sampling from green reed during springtime is not recommended, since this is the colonization time of periphyton on the newly growing reed, but it may be appropriate from the second half of the vegetation period. Stone and artificially placed old reed substrata may be appropriate for biomonitoring of shallow soda lakes in both spring and autumn since they showed in both seasons similar results regarding all measured features
Should red cell transfusion be individualized? Yes
SCOPUS: ed.jinfo:eu-repo/semantics/publishe
Catastrophizing mediates the relationship between the personal belief in a just world and pain outcomes among chronic pain support group attendees
Health-related research suggests the belief in a just world can act as a personal resource that protects against the adverse effects of pain and illness. However, currently, little is known about how this belief, particularly in relation to one’s own life, might influence pain. Consistent with the suggestions of previous research, the present study undertook a secondary data analysis to investigate pain catastrophizing as a mediator of the relationship between the personal just world belief and chronic pain outcomes in a sample of chronic pain support group attendees. Partially supporting the hypotheses, catastrophizing was negatively correlated with the personal just world belief and mediated the relationship between this belief and pain and disability, but not distress. Suggestions for future research and intervention development are made
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