4,085 research outputs found
Anomaly Cancelation in Field Theory and F-theory on a Circle
We study the manifestation of local gauge anomalies of four- and
six-dimensional field theories in the lower-dimensional Kaluza-Klein theory
obtained after circle compactification. We identify a convenient set of
transformations acting on the whole tower of massless and massive states and
investigate their action on the low-energy effective theories in the Coulomb
branch. The maps employ higher-dimensional large gauge transformations and
precisely yield the anomaly cancelation conditions when acting on the one-loop
induced Chern-Simons terms in the three- and five-dimensional effective theory.
The arising symmetries are argued to play a key role in the study of the
M-theory to F-theory limit on Calabi-Yau manifolds. For example, using the fact
that all fully resolved F-theory geometries inducing multiple Abelian gauge
groups or non-Abelian groups admit a certain set of symmetries, we are able to
generally show the cancelation of pure Abelian or pure non-Abelian anomalies in
these models.Comment: 48 pages, 2 figures; v2: typos corrected, comments on circle fluxes
adde
Gauge Fluxes in F-theory and Type IIB Orientifolds
We provide a detailed correspondence between G_4 gauge fluxes in F-theory
compactifications with SU(n) and SU(n)x(1) gauge symmetry and their Type IIB
orientifold limit. Based on the resolution of the relevant F-theory Tate models
we classify the factorisable G_4-fluxes and match them with the set of
universal D5-tadpole free U(1)-fluxes in Type IIB. Where available, the global
version of the universal spectral cover flux corresponds to Type IIB gauge flux
associated with a massive diagonal U(1). In U(1)-restricted Tate models extra
massless abelian fluxes exist which are associated with specific linear
combinations of Type IIB fluxes. Key to a quantitative match between F-theory
and Type IIB is a proper treatment of the conifold singularity encountered in
the Sen limit of generic F-theory models. We also shed further light on the
brane recombination process relating generic and U(1)-restricted Tate models.Comment: 53 pages, 3 figures; v2: Refs added; v3: minor corrections to match
version published in JHE
Seasonal variations in the aragonite saturation state in the upper open-ocean waters of the North Pacific Ocean
Seasonal variability of the aragonite saturation state ((AR)) in the upper (50m and 100m depths) North Pacific Ocean (NPO) was investigated using multiple linear regression (MLR). The MLR algorithm derived from a high-quality carbon data set accurately predicted the (AR) of evaluation data sets (three time series stations and P02 section) with acceptable uncertainty (<0.1(AR)). The algorithm was combined with seasonal climatology data, and the estimated (AR) varied in the range of 0.4-0.6 in the midlatitude western NPO, with the largest variation found for the tropical eastern NPO. These marked variations were largely controlled by seasonal changes in vertical mixing and thermocline depth, both of which determine the degree of entrainment of CO2-rich corrosive waters from deeper depths. Our MLR-based subsurface (AR) climatology is complementary to surface climatology based on pCO(2) measurements.1184Ysciescopu
F-Theory and the Mordell-Weil Group of Elliptically-Fibered Calabi-Yau Threefolds
The Mordell-Weil group of an elliptically fibered Calabi-Yau threefold X
contains information about the abelian sector of the six-dimensional theory
obtained by compactifying F-theory on X. After examining features of the
abelian anomaly coefficient matrix and U(1) charge quantization conditions of
general F-theory vacua, we study Calabi-Yau threefolds with Mordell-Weil
rank-one as a first step towards understanding the features of the Mordell-Weil
group of threefolds in more detail. In particular, we generate an interesting
class of F-theory models with U(1) gauge symmetry that have matter with both
charges 1 and 2. The anomaly equations --- which relate the Neron-Tate height
of a section to intersection numbers between the section and fibral rational
curves of the manifold --- serve as an important tool in our analysis.Comment: 29 pages + appendices, 5 figures; v2: minor correction
Six-dimensional (1,0) effective action of F-theory via M-theory on Calabi-Yau threefolds
The six-dimensional effective action of F-theory compactified on a singular
elliptically fibred Calabi-Yau threefold is determined by using an M-theory
lift. The low-energy data are derived by comparing a circle reduction of a
general six-dimensional (1,0) gauged supergravity theory with the effective
action of M-theory on the resolved Calabi-Yau threefold. The derivation
includes six-dimensional tensor multiplets for which the (anti-) self-duality
constraints are imposed on the level of the five-dimensional action. The vector
sector of the reduced theory is encoded by a non-standard potential due to the
Green-Schwarz term in six dimensions. This Green-Schwarz term also contains
higher curvature couplings which are considered to establish the full map
between anomaly coefficients and geometry. F-/M-theory duality is exploited by
moving to the five-dimensional Coulomb branch after circle reduction and
integrating out massive vector multiplets and matter hypermultiplets. The
associated fermions then generate additional Chern-Simons couplings at
one-loop. Further couplings involving the graviphoton are induced by quantum
corrections due to excited Kaluza-Klein modes. On the M-theory side integrating
out massive fields corresponds to resolving the singularities of the Calabi-Yau
threefold, and yields intriguing relations between six-dimensional anomalies
and classical topology.Comment: 55 pages, v2: typos corrected, discussion of loop corrections
improve
Value-added Synthesis of Graphene: Recycling Industrial Carbon Waste into Electrodes for High-Performance Electronic Devices
We have developed a simple, scalable, transfer-free, ecologically sustainable, value-added method to convert inexpensive coal tar pitch to patterned graphene films directly on device substrates. The method, which does not require an additional transfer process, enables direct growth of graphene films on device substrates in large area. To demonstrate the practical applications of the graphene films, we used the patterned graphene grown on a dielectric substrate directly as electrodes of bottom-contact pentacene field-effect transistors (max. field effect mobility similar to 0.36 cm(2).V-1.s(-1)), without using any physical transfer process. This use of a chemical waste product as a solid carbon source instead of commonly used explosive hydrocarbon gas sources for graphene synthesis has the dual benefits of converting the waste to a valuable product, and reducing pollution.111714Ysciescopu
Structure in 6D and 4D N=1 supergravity theories from F-theory
We explore some aspects of 4D supergravity theories and F-theory vacua that
are parallel to structures in the space of 6D theories. The spectrum and
topological terms in 4D supergravity theories correspond to topological data of
F-theory geometry, just as in six dimensions. In particular, topological
axion-curvature squared couplings appear in 4D theories; these couplings are
characterized by vectors in the dual to the lattice of axion shift symmetries
associated with string charges. These terms are analogous to the Green-Schwarz
terms of 6D supergravity theories, though in 4D the terms are not generally
linked with anomalies. We outline the correspondence between F-theory topology
and data of the corresponding 4D supergravity theories. The correspondence of
geometry with structure in the low-energy action illuminates topological
aspects of heterotic-F-theory duality in 4D as well as in 6D. The existence of
an F-theory realization also places geometrical constraints on the 4D
supergravity theory in the large-volume limit.Comment: 63 page
On Instanton Effects in F-theory
We revisit the issue of M5-brane instanton corrections to the superpotential
in F-theory compactifications on elliptically fibered Calabi-Yau fourfolds.
Elaborating on concrete geometries, we compare the instanton zero modes for
non-perturbative F-theory models with the zero modes in their perturbative Sen
limit. The fermionic matter zero modes localized on the intersection of the
instanton with the space-time filling D7-branes show up in a geometric way in
F-theory. Methods for their computation are developed and, not surprisingly,
exceptional gauge group structures do appear. Finally, quite intriguing
geometrical aspects of the one-loop determinant are discussed.Comment: 52 pages, 8 figures, 13 tables; v2: extended discussion of matter
zero modes, refs added; v3: sections 3.3 + 4.1 restructure
Flexible Programming of Cell-Free Protein Synthesis Using Magnetic Bead-Immobilized Plasmids
The use of magnetic bead-immobilized DNA as movable template for cell-free protein synthesis has been investigated. Magnetic microbeads containing chemically conjugated plasmids were used to direct cell-free protein synthesis, so that protein generation could be readily programmed, reset and reprogrammed. Protein synthesis by using this approach could be ON/OFF-controlled through repeated addition and removal of the microbead-conjugated DNA and employed in sequential expression of different genes in a same reaction mixture. Since the incubation periods of individual template plasmids are freely controllable, relative expression levels of multiple proteins can be tuned to desired levels. We expect that the presented results will find wide application to the flexible design and execution of synthetic pathways in cell-free chassis
Dll4 Suppresses Transcytosis for Arterial Blood-Retinal Barrier Homeostasis
Rationale: Central nervous system has low vascular permeability by organizing tight junction (TJ) and limiting endothelial transcytosis. While TJ has long been considered to be responsible for vascular barrier in central nervous system, suppressed transcytosis in endothelial cells is now emerging as a complementary mechanism. Whether transcytosis regulation is independent of TJ and its dysregulation dominantly causes diseases associated with edema remain elusive. Dll4 signaling is important for various vascular contexts, but its role in the maintenance of vascular barrier in central nervous system remains unknown. /
Objective: To find a TJ-independent regulatory mechanism selective for transcytosis and identify its dysregulation as a cause of pathological leakage. /
Methods and Results: We studied transcytosis in the adult mouse retina with low vascular permeability and employed a hypertension-induced retinal edema model for its pathological implication. Both antibody-based and genetic inactivation of Dll4 or Notch1 induce hyperpermeability by increasing transcytosis without junctional destabilization in arterial endothelial cells, leading to nonhemorrhagic leakage predominantly in the superficial retinal layer. Endothelial Sox17 deletion represses Dll4 in retinal arteries, phenocopying Dll4 blocking-driven vascular leakage. Ang II (angiotensin II)âinduced hypertension represses arterial Sox17 and Dll4, followed by transcytosis-driven retinal edema, which is rescued by a gain of Notch activity. Transcriptomic profiling of retinal endothelial cells suggests that Dll4 blocking activates SREBP1 (sterol regulatory element-binding protein 1)-mediated lipogenic transcription and enriches gene sets favorable for caveolae formation. Profiling also predicts the activation of VEGF (vascular endothelial growth factor) signaling by Dll4 blockade. Inhibition of SREBP1 or VEGF-VEGFR2 (VEGF receptor 2) signaling attenuates both Dll4 blockadeâdriven and hypertension-induced retinal leakage. /
Conclusions: In the retina, Sox17-Dll4-SREBP1 signaling axis controls transcytosis independently of TJ in superficial arteries among heterogeneous regulations for the whole vessels. Uncontrolled transcytosis via dysregulated Dll4 underlies pathological leakage in hypertensive retina and could be a therapeutic target for treating hypertension-associated retinal edema
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