Mesta vseživljenjskega učenja v Koreji z vidika usmeritve v učečo se družbo

The learning city aims for a just learning society, emphasising the subjective participation of citizens and providing them with equal learning opportunities. The purpose of the paper is to examine, through a literature review method, whether Korea’s lifelong learning cities have achieved the formation of a learning society. In Korea learning cities have led to the provision of more learning opportunities for citizens and improved the quality of education programmes. There also exists a movement for citizens to participate in the learning city project as citizen activists. However, it is not yet possible to assess that most learning cities are developed and built by citizens’ engagement. Moreover, there is even a tendency for inequality to be intensified in lifelong education. Therefore, Korea’s learning cities will need to further solidify their citizen-led perspective, including democratic decision-making and the free expression of opinions by citizens, in order to move toward a just learning society.Cilj učečega se mesta je pravična učeča se družba, ki poudarja sodelovanje državljanov in enake priložnosti za učenje. Namen članka je s pregledom literature ugotoviti, ali je korejskim mestom vseživljenjskega učenja uspelo oblikovati učečo se družbo. V Koreji so učeča se mesta povečala priložnosti za učenje in izboljšala kakovost izobraževalnih programov. Izoblikovalo se je tudi gibanje, ki podpira aktivno sodelovanje prebivalcev v projektu učečih se mest. Kljub temu pa še ne moremo reči, da se večina učečih se mest razvija in gradi na podlagi delovanja prebivalcev samih. Pokazala se je tudi težnja, da se neenakosti na podlagi vseživljenjskega učenja celo poglabljajo. Da bo Koreja postala prava učeča se družba, bo treba okrepiti vlogo, ki jo v teh mestih igrajo prebivalci sami, to pa vključuje tudi krepitev demokratičnega odločanja in svobode izražanja

The Limits of Dewey’s Philosophy: Cultural Historical Activity Theory and Experience

This paper argues that activity theory, specifically cultural historical activity theory (CHAT), has explored the concepts of mediation, tools, signs, and appropriation as a means to overcome the inherent dualism in Dewey’s theory of experience and learning

An integrated clinical and genomic information system for cancer precision medicine

Abstract Background Increasing affordability of next-generation sequencing (NGS) has created an opportunity for realizing genomically-informed personalized cancer therapy as a path to precision oncology. However, the complex nature of genomic information presents a huge challenge for clinicians in interpreting the patient’s genomic alterations and selecting the optimum approved or investigational therapy. An elaborate and practical information system is urgently needed to support clinical decision as well as to test clinical hypotheses quickly. Results Here, we present an integrated clinical and genomic information system (CGIS) based on NGS data analyses. Major components include modules for handling clinical data, NGS data processing, variant annotation and prioritization, drug-target-pathway analysis, and population cohort explorer. We built a comprehensive knowledgebase of genes, variants, drugs by collecting annotated information from public and in-house resources. Structured reports for molecular pathology are generated using standardized terminology in order to help clinicians interpret genomic variants and utilize them for targeted cancer therapy. We also implemented many features useful for testing hypotheses to develop prognostic markers from mutation and gene expression data. Conclusions Our CGIS software is an attempt to provide useful information for both clinicians and scientists who want to explore genomic information for precision oncology

Additional file 6: of An integrated clinical and genomic information system for cancer precision medicine

Figure S4. An example of filtering process to select a patient cohort based on clinical information or properties. A. Selection of female and lifelong never-smoker patients in the TCGA LUAD cohort. (“Cohort Selection” menu is located in left-top side of the page) B. Driver genes were sorted by mutation frequency by clicking the “# Mutations” label at the bottom. The sorting result confirmed that EGFR is the most frequently mutated gene among these patients, whereas TP53 mutation was prevalent in other patients as shown in Additional file 7: Figure S3. (PNG 179 kb

Additional file 1: of An integrated clinical and genomic information system for cancer precision medicine

Figure S1. Galaxy workflow for WES data processing. (PNG 221 kb

Additional file 2: of An integrated clinical and genomic information system for cancer precision medicine

Figure S2. Galaxy workflow for WTS data processing. (PNG 111 kb

Additional file 4: of An integrated clinical and genomic information system for cancer precision medicine

Galaxy workflow file (json data format) for WTS data processing, it can be imported to another Galaxy server. (GA 23 kb

Additional file 7: of An integrated clinical and genomic information system for cancer precision medicine

Figure S3. Cohort explorer for the whole TCGA LUAD cohort and our patient (1) Significant driver genes identified by MutSigCV [22]. Each horizontal bar represents total count of mutations on the corresponding gene in the cohort. Color scheme indicates the coding properties of mutations. (2) The gray bar represents –log10(p-values) of each driver gene. (3) Sample-wise count of mutations with coding properties color-coded. (4) Clinical features of samples. (5) Mutations found in our patient are plotted at left-most side (i.e. the first column). (PNG 120 kb

Additional file 5: of An integrated clinical and genomic information system for cancer precision medicine

Instruction for users to upload their own FASTQ files into our BioCloud system so that they can process the NGS data and get the various reports described in main script. (PDF 1060 kb

Additional file 3: of An integrated clinical and genomic information system for cancer precision medicine

Galaxy workflow file (json data format) for WES data processing, it can be imported to another Galaxy server. (GA 53 kb