A Neighborhood Threatened: The North 5th Street Corridor and Korean Business Flight

This study examines a Korean business community\u27s potential for movement out of the city of Philadelphia. The research is based on three months of fieldwork at various Korean businesses in North Philadelphia, from 5100 to 6100 North 5th Street. This area is a major commercial district for the Olney community, a district that has a high proportion of Korean businesses. The author concluded that the Korean business community will leave the city in the near future for three main reasons. First, the Korean population in Philadelphia is moving out of the city while there is an influx of Koreans into the suburbs. The businesses will follow the Korean population. Second, the businesses themselves show direct and indirect signs of movement. The increasing African Americanization of the neighborhood combined with the racial prejudice that Korean business owners displayed against blacks was the final indicator of potential movement. Because Korean businesses leaving the area could potentially destabilize the district, the effects can be mitigated by initiating policies to bring business owners back to the area

Tangible User Interface Design for Home Automation Energy Management Appliances

Home Automation System connects the digital technology and computers to the appliances at home and manages it. It's the frequency of use an position in the home that makes it important to have an aesthetic friendly user interface. There are numerous UI design cases of Display panel or the buttons. However, the usability or aesthetic sensibility design through using a variety of multi-layered emotional satisfaction of feeling that provides the interface design needs to be studied. This study explores the ways to satisfy the emotional needs of Home Automation System and Tangible User Interface (TUI).OAIID:oai:osos.snu.ac.kr:snu2010-01/104/0000025799/16SEQ:16PERF_CD:SNU2010-01EVAL_ITEM_CD:104USER_ID:0000025799ADJUST_YN:NEMP_ID:A075458DEPT_CD:611CITE_RATE:0FILENAME:Tangible User Interface Design for Home Automation Energy Management Appliances.pdfDEPT_NM:디자인학부EMAIL:[email protected]:

The effect of sex and physical frailty on incident disability after 2 years among community-dwelling older adults: KFACS study

Background : This study investigated the impact of physical frailty on the development of disabilities in mobility, activities of daily living (ADL), and instrumental activities of daily living (IADL) according to sex among community-dwelling Korean older adults. Methods : We used data of 2,905 older adults aged 70-84 years from the Korean Frailty and Aging Cohort Study (KFACS) at baseline (2016-2017) and Wave 2 (2018-2019). Fried’s physical frailty phenotype was used to identify frailty. Results : After adjustment, frailty showed a higher impact for women than men on developing mobility disability (odds ratio [OR]=14.00, 95% confidence interval [CI]=4.8–40.78 vs. OR=9.89, 95% CI=4.28–22.86) and IADL disability after two years (OR=7.22, 95% CI=2.67–19.56 vs. OR=3.19, 95% CI=1.17–8.70). Pre-frailty led to mobility disability for women and men (OR=2.77, 95% CI=1.93–3.98 vs. OR=2.49, 95% CI=1.66–3.72, respectively), and IADL disability only for women (OR=3.01, 95% CI=1.28–7.09). Among the IADL components, both men and women who were prefrail or frail showed increased disability in ‘using transportation’. Among men, pre-frailty was significantly associated with disability in “going out” and “shopping”. In women, frailty was significantly associated with disability in “doing laundry,” “performing household chores,” “shopping,” and “managing money”. Conclusions : Physical frailty increased disability over 2 years for women more than men. Physical frailty increased disability in outdoor activity-related IADL components in men and household work-related IADL components in women. This study highlights the need for gender-specific policies and preventative programs for frailty, particularly restorative interventions that focus on women who are physically frail.This research was supported by a grant from the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), which is funded by the Ministry of Health & Welfare, Republic of Korea (grant number: HI15C3153), and the Research Program funded by the National Institute of Health, Korea Disease Control and Prevention Agency (2021-ER060500). The funding bodies had no role in the study design the collection, analysis and interpretation of the data; the writing of the report; or the decision to submit this article for publication

PER, a Circadian Clock Component, Mediates the Suppression of MMP-1 Expression in HaCaT Keratinocytes by cAMP

Skin circadian clock system responds to daily changes, thereby regulating skin functions. Exposure of the skin to UV irradiation induces the expression of matrix metalloproteinase-1 (MMP-1) and causes DNA damage. It has been reported both DNA repair and DNA replication are regulated by the circadian clock in mouse skin. However, the molecular link between circadian clock and MMP-1 has little been investigated. We found PERIOD protein, a morning clock component, represses the expression of MMP-1 in human keratinocytes by using a PER-knockdown strategy. Treatment with siPer3 alleviated the suppression of MMP-1 expression induced by forskolin. Results revealed PER3 suppresses the expression of MMP-1 via cAMP signaling pathway. Additionally, we screened for an activator of PER that could repress the expression of MMP-1 using HaCaT cell line containing PER promoter-luciferase reporter gene. Results showed Lespedeza capitate extract (LCE) increased PER promoter activity. LCE inhibited the expression of MMP-1 and its effect of LCE was abolished in knockdown of PER2 or PER3, demonstrating LCE can repress the expression of MMP-1 through PER. Since circadian clock component PER can regulate MMP-1 expression, it might be a new molecular mechanism to develop therapeutics to alleviate skin aging and skin cancer

Biomarker Discovery of Acute Coronary Syndrome Using Proteomic Approach

Acute coronary syndrome (ACS) is a condition in which the coronary artery supplying blood to the heart is infarcted via formation of a plaque and thrombus, resulting in abnormal blood supply and high mortality and morbidity. Therefore, the prompt and efficient diagnosis of ACS and the need for new ACS diagnostic biomarkers are important. In this study, we aimed to identify new ACS diagnostic biomarkers with high sensitivity and specificity using a proteomic approach. A discovery set with samples from 20 patients with ACS and 20 healthy controls was analyzed using mass spectrometry. Among the proteins identified, those showing a significant difference between each group were selected. Functional analysis of these proteins was conducted to confirm their association with functions in the diseased state. To determine ACS diagnostic biomarkers, standard peptides of the selected protein candidates from the discovery set were quantified, and these protein candidates were validated in a validation set consisting of the sera of 50 patients with ACS and 50 healthy controls. We showed that hemopexin, leucine-rich α-2-glycoprotein, and vitronectin levels were upregulated, whereas fibronectin level was downregulated, in patients with ACS. Thus, the use of these biomarkers may increase the accuracy of ACS diagnosis

The Alleviating Effect of <i>Lagerstroemia indica</i> Flower Extract on Stretch Marks through Regulation of Mast Cells

Striae distensae (SD) or stretch marks are common linear scars of atrophic skin with disintegrating extracellular matrix (ECM) structures. Although fibroblasts contribute to the construction of ECM structure in SD, some studies have reported that mast cell degranulation causes the disruption of ECM in early SD lesions. Lagerstroemia indica flower (LIF) has traditionally been used in India as a diuretic. However, little is known about the effect and molecular action of Lagerstroemia indica flower extract (LIFE) on alleviating SD. This study evaluated the effects of LIFE on mast cell degranulation and the synthesis of ECM components in fibroblasts. LIFE inhibits the adhesion of rat basophilic leukemia (RBL) cells, RBL-2H3 on fibronectin (FN) and the expression of integrin, a receptor for FN, thereby reducing focal adhesion kinase (FAK) phosphorylation. In addition, LIFE attenuated the allergen-induced granules and cytokine interleukin 3 (IL-3) through the adhesion with FN. Moreover, the conditioned medium (CM) of activated mast cells decreases the synthesis of ECM components, and LIFE restores the abnormal expressions induced by activated mast cells. These results demonstrate that LIFE suppresses FN-induced mast cell activation and promotes the synthesis of ECM components in fibroblast, which indicates that LIFE may be a useful cosmetic agent for SD treatment

Reduced Graphene Oxide-Wrapped Nickel-Rich Cathode Materials for Lithium Ion Batteries

The encapsulation of Ni-rich cathode materials (LiNi_0.6Co_0.2Mn_0.2O₂) for lithium ion batteries in reduced graphene oxide (rGO) sheets is introduced to improve electrochemical performances. Using (3-aminopropyl)­triethoxysilane, the active materials are completely wrapped with several rGO layers of ∼2 nm thickness. By virtue of the great electrical conductivity of graphene, the rGO-coated cathode materials exhibit much enhanced electrochemical performances of cycling property and rate capability. In addition, it is shown that the structural degradation of the active materials, which is from the rhombohedral layered structure (<i>R</i>3̅<i>m</i>) to the spinel (<i>Fd</i>3̅<i>m</i>) or rock-salt phase (<i>Fm</i>3̅<i>m</i>), is significantly reduced as well as delayed due to the protection of the active materials in the rGO layers from direct contact with electrolytes and the consequent suppression of side reactions