1,107 research outputs found
COMPARATIVE ANALYSIS OF YANG HAK-SEON VAULT AND TSUKAHARA 1260? VAULT IN GYMNASTICS
The study was a single-subject study on the top-elite vaulter in the world. This study was purposed to compare kinematic differences between Yang Hak-Seon vault (Yang-1) and Tsukahara 1260? vault (Yang-2) performed by Yang Hak-Seon. Fourteen high-speed cameras were used to capture a whole body segment motion of Yang-2 vault during the practice session. Yang-1 vault showed faster CM vertical velocity until the vault table takeoff and faster CM horizontal velocity prior to the vault table touchdown. However, the trunk rotation angle and its angular velocity of Yang-2 vault exceeded Yang-1 vault significantly. This might be due to a half turn off the springboard onto the vault table of Yang-2 vault, which resulted in larger initial angular momentum at the vault table touchdown and further increase in angular velocity during the vault table contact
Cancer Statistics in Korea: Incidence, Mortality, Survival, and Prevalence in 2008
PURPOSE: This paper overviews the nationwide cancer statistics including incidence, mortality, survival and prevalence, and their trends in Korea based on the year 2008 cancer incidence data.
MATERIALS AND METHODS: Incidence data from 1993 to 2008 were obtained from the Korea National Cancer Incidence Database, and the vital status was followed through December 31, 2009. Mortality data from 1983 to 2008 were obtained from the Korea National Statistics Office. Crude rates and age-standardized rates for incidence, mortality, prevalence and relative survival were calculated.
RESULTS: There were 178,816 cancer cases and 68,912 cancer deaths observed during year 2008 and 724,663 10-year cancer prevalent cases as of January 1, 2009 in Korea. The incidence rate for all cancer combined showed an annual increase of 3.1% from 1999 to 2008.
CONCLUSION: With significantly increasing cancer incidence, Korea faces a large cancer burden and efficient cancer control programs are essential.ope
Improvisation of classification performance based on feature optimization for differentiation of Parkinson’s disease from other neurological diseases using gait characteristics
Most neurological disorders that include Parkinson’s disease (PD) as well as other neurological diseases such as Amyotrophic Lateral Sclerosis (ALS) and Huntington’s disease (HD) have some common abnormalities regarding the movement, vocal, and cognitive behaviors of sufferers. Variations in the manifestation of these types of abnormality help distinguish one disorder from another. In this study, differentiation was performed based on the gait characteristics of patients afflicted by different neurological disorders. In the recent past, many researchers have applied different machine learning and feature selection techniques to the classification of different groups of patients based on common abnormalities. However, in an era of modernization where the focus is on timely low-cost automatization and pattern recognition, such techniques require improvisation to provide high performance. We attempted to improve the performance of such techniques using different feature optimization methods, such as a genetic algorithm (GA) and principal component analysis (PCA), and applying different classification approaches, i.e., linear, nonlinear, and probabilistic classifiers. In this study, gait dynamics data of patients suffering with PD, ALS, and HD were collated from a public database, and a binary classification approach was used by taking PD as one group and adopting ALS+HD as another group. Performance comparison was achieved using different classification techniques that incorporated optimized feature sets obtained from GA and PCA. In comparison with other classifiers using different feature sets, the highest accuracy (97.87%) was obtained using random forest combined with GA-based feature sets. The results provide evidence that could assist medical practitioners in differentiating PD from other neurological diseases using gait characteristics
Multiparametric Design of an All-Metal, Broadband, Slant Dual-Polarized Vivaldi Array Antenna
An all-metal, broadband, dual-polarized Vivaldi array antenna was designed and fabricated. The structure of the proposed antenna comprised a resonant cavity and tapered fins that contacted the ground plane directly, allowing the connection of a balun and tapered fins and reducing the antenna length. To extend the frequency range, the resonant cavity width is larger than half the aperture length, and the tapered fins have nonuniform thickness. The proposed Vivaldi array antenna is designed based on parametric studies. The gains of the active element and array ranged from −2.9 dBi to 6.4 dBi and 14.9 to 23.5 dBi in the frequency range of 2–6 GHz. The proposed array antenna exhibited beam steering capability up to 45° along the azimuth and 25° along the elevation angle directions. Since the measured results and simulated predictions were in good agreement, the proposed array antenna would be applicable for a broadband, wide-beam steering system with different polarization requirements
Prediction of Cancer Incidence and Mortality in Korea, 2011
PURPOSE: To estimate the current cancer burden in Korea, cancer incidence and mortality were projected for the year 2011.
MATERIALS AND METHODS: The cancer incidence data from 1999-2008 were obtained from the Korea National Cancer Incidence Database, and the cancer mortality data from 1993-2009 were obtained from the Korea National Statistics Office. Cancer incident cases and rates in 2011 were projected from fitting a linear regression model on observed age-specific cancer incidence rates against observed years, then multiplying the projected age-specific rates by the age-specific population. For cancer mortality, a similar procedure was applied for projection except that a Joinpoint regression model was used to determine at which year the linear trend significantly changed.
RESULTS: A total of 216,809 new cancer cases and 71,036 cancer deaths are projected to occur in Korea in 2011. For all sites combined, the crude incidence rates are projected to be 437.9 and 420.5 and the age-standardized incidence rates are projected to be 336.5 and 279.7 per 100,000 for men and women, respectively.
CONCLUSION: Cancer has become an important public health concern in Korea, and as Korea becomes an aged society, the cancer burden will continue to increase.ope
Cancer Statistics in Korea: Incidence, Mortality and Survival in 2006-2007
Cancer has been the leading cause of death in Korea. Korea is facing a very rapid change and increase in cancer incidence, which draws much attention in public health. This paper overviews the nationwide cancer statistics, including incidence, mortality, and survival rates, and their trends in Korea based on the cancer incidence data from The Korea Central Cancer Registry (KCCR) in year 2006 and 2007. In Korea, there were 153,237 cancer cases and 65,519, cancer deaths observed in 2006, and 161,920 cancer cases and 67,561 cancer deaths in 2007, respectively. The incidence rate for all cancer combined showed an annual increase of 2.8% from 1999 to 2007. Specifically, there was significant increase in the incidence of colorectal, thyroid, female breast, and prostate cancers. The number of cancer deaths has increased over the past two decades, due mostly to population aging, while the age-standardized mortality rates have decreased in both men and women since 2002. Notable improvement has been observed in the 5-yr relative survival rates for most major cancers and for all cancer combined, with the exception of pancreatic cancer. The nationwide cancer statistics in this paper will provide essential data for cancer research and evidence-based health policy in Korea
Nuclear factor I-C regulates E-cadherin via control of KLF4 in breast cancer
This is an Open Access article distributed under the terms of the Creative
Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and
reproduction in any medium, provided the original work is properly credited.Abstract
Background
Progression to metastasis is the leading cause of most cancer-related mortality; however, much remains to be understood about what facilitates the spread of tumor cells. In the present study, we describe a novel pathway in breast cancer that regulates epithelial-to-mesenchymal transition (EMT), motility, and invasiveness.
Methods
We examined nuclear factor I-C (NFI-C) expression in MCF10A human breast epithelial cells, MCF7 non-invasive breast cancer cells, and MDA-MB231 invasive breast cancer cells by real-time PCR and western blotting. To investigate the loss- and gain-function of NFI-C, we determined whether NFI-C regulated KLF4 expression by real-time PCR, western blotting, and promoter assay. To understand the biological functions of NFI-C, we observed cell invasion, migration, adhesion in human tumor cells by transwell assay, wound healing assay, quantitative RT-PCR, cell adhesion assay, western blotting, and immunohistochemistry.
Results
We identified the downstream factors of NFI-C, such as KLF4 and E-cadherin, which play roles in EMT. NFI-C is expressed in normal mammary gland or noninvasive breast cancer cells with epithelial characteristics. NFI-C overexpression induced expression of KLF4 and E-cadherin, but not Slug, in breast cancer cells. NFI-C bound directly to the KLF4 promoter and stimulated KLF4 transcriptional activity, thereby regulating E-cadherin expression during tumorigenesis. Cells overexpressing NFI-C maintained their epithelial differentiation status, which could drive mesenchymal-epithelial transition (MET) via the NFI-C-KLF4-E-cadherin axis in breast cancer cells. Consequently, NFI-C suppressed EMT, migration, and invasion in breast cancer cells.
Conclusions
Our study reveals a novel signaling pathway that is important during breast cancer tumorigenesis: the NFI-C-KLF4-E-cadherin pathway. The results indicate the important role of NFI-C in regulating KLF4 during tumorigenesis
KINEMATIC COMPARISONS OF KETTLEBELL TWO-ARM SWINGS BETWEEN EXPERTS AND BEGINNERS
The purpose of this study was to investigate kinematic comparisons of kettlebell two-arm swings between experts and beginners in order to find out biomechanical key points for preventing sports injuries and enhancing kettlebell performance. Four experts and three beginners performed kettlebell two-arm swings fifteen times with a 16 kg kettlebell. Experts demonstrated larger ranges of motions (ROM) of pelvic segment and hip joint than beginners, while beginners revealed larger ROM of shoulder joint than experts. Magnitudes and sequential orders of peak angular velocities of major joints were significantly different between two groups. Conclusively, the mobility of pelvic segment and hip joint are required, while the stability of the other joint are needed to produce appropriate kettlebell two-arm swings. The activation and strength of gluteus muscles would be key contributors
Primary Uterine Lymphoma: A Case Report
Primary lymphoma of the uterus is a rare disease, the reported characteristic MR imaging findings being homogeneous intermediate signal intensity of the indistinct mass on T1- and T2-weighted images, and the preservation of endometrial lining and uterine architecture. We report a case of primary uterine lymphoma which showed tumoral necrosis, endometrial disruption and diffuse anterior vaginal wall involvement
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