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Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/111284/1/j.1532-5415.2000.tb04711.x.pd

The Martin and Park Environmental Demands (MPED) Questionnaire: Psychometric properties of a brief instrument to measure self-reported environmental demands

Background and aims: The present study examines the usefulness of a newly developed instrument, the Martin and Park Environmental Demands (MPED) Questionnaire, to measure the level of self-reported environmental demands of day-to-day events faced by adults aged 35 to 84 years, particularly as these demands influence forgetfulness in taking medications. Methods: The MPED has two scales including Busyness, which addresses the density or pace of daily events to which an individual attends; and Routine, addressing the predictability or routinization of events independent of density. The MPED was administered to a sample of 121 rheumatoid arthritis patients, along with a baseline assessment battery measuring age, education, employment status, household size and other factors that might influence self-perception of Busyness and Routine. Results: The scale showed good internal consistency and external validity. Higher levels of environmental demand were negatively correlated with age and positively correlated with employment, household size and medication-taking errors. There was a significant independent association between Busyness and adherence errors even after controlling for the effects of these sociodemographic variables. Conclusions: The MPED is recommended when trying to assess the general daily level of environmental demand

Implementation and Impact of the Patient Self-Determination Act

The Patient Self-Determination Act became effective in December 1991 and mandates that patients be given information about legal rights regarding living wills and durable powers of attorney for health care. We investigated the impact this law has had on hospitals, medical personnel, and patients. We conducted a survey of all hospitals in the state of Georgia, collecting data regarding implementation and knowledge of the law, as well as effects of the law and beliefs about it. The data indicated that hospitals relied primarily on the Georgia Hospital Association for implementation policy, that minimalist implementation of the law occurs in most hospitals, and that the biggest perceived problem with the law was the inappropriateness of presenting this information at hospital admission and problems patients had in comprehending the materials presented. Despite these concerns, most respondents did not want the law repealed

Young and Old Adults' Concerns About Morality and Competence

Two experiments were conducted to examine people's sensitivity to person information from the morality domain (relation-oriented) and the competence domain (task & achievement-oriented). In a lexical decision paradigm, the findings from Experiment 1 showed that younger adults were faster to identify person cues (trait words) from the morality than from the competence domain, especially cues that were related to immorality. Experiment 2 compared the responses of younger and older adults. Despite the slower responses of the older adults, the findings indicated that all participants were faster at identifying cues from the morality domain than from the competence domain, with no age interactions. The results from Experiment 2 also suggested that disparate findings in the literature regarding reaction times to morality/competence cues and valence (positive or negative) were a function of word frequency effects. The findings are discussed in terms of people's chronic concern with the moral aspects of others as invariant across the lifespan, given that the morality domain is where interpersonal costs and threats are most likely to be signaled.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/45370/1/11031_2004_Article_343706.pd

Age‐dependent amyloid deposition is associated with white matter alterations in cognitively normal adults during the adult life span

Introduction Both beta‐amyloid (Ab) deposition and decline in white matter integrity, are brain alterations observed in Alzheimer's disease (AD) and start to occur by the fourth and fifth decades. However, the association between both brain alterations in asymptomatic subjects is unclear. Methods Amyloid positron emission tomography (PET) and diffusion tensor imaging (DTI) were obtained in 282 cognitively normal subjects (age 30‐89 years). We assessed the interaction of age by abnormal amyloid PET status (Florbetapir F‐18 PET >1.2 standard uptake value ratio [SUVR]) on regional mean diffusivity (MD) and global white matter hyperintensity (WMH) volume, controlled for sex, education, and hypertension. Results Subjects with abnormal amyloid PET (n = 87) showed stronger age‐related increase in global WMH and regional MD, particularly within the posterior parietal regions of the white matter. Discussion Sporadic Aβ deposition is associated with white matter alterations in AD predilection areas in an age‐dependent manner in cognitively normal individuals

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No abstract.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/34302/1/10320_ftp.pd

Loss of MECP2 Leads to Activation of P53 and Neuronal Senescence.

To determine the role for mutations of MECP2 in Rett syndrome, we generated isogenic lines of human induced pluripotent stem cells, neural progenitor cells, and neurons from patient fibroblasts with and without MECP2 expression in an attempt to recapitulate disease phenotypes in vitro. Molecular profiling uncovered neuronal-specific gene expression changes, including induction of a senescence-associated secretory phenotype (SASP) program. Patient-derived neurons made without MECP2 showed signs of stress, including induction of P53, and senescence. The induction of P53 appeared to affect dendritic branching in Rett neurons, as P53 inhibition restored dendritic complexity. The induction of P53 targets was also detectable in analyses of human Rett patient brain, suggesting that this disease-in-a-dish model can provide relevant insights into the human disorder

Investigating Unique Environmental Contributions to the Neural Representation of Written Words: A Monozygotic Twin Study

The visual word form area (VWFA) is a region of left inferior occipitotemporal cortex that is critically involved in visual word recognition. Previous studies have investigated whether and how experience shapes the functional characteristics of VWFA by comparing neural response magnitude in response to words and nonwords. Conflicting results have been obtained, however, perhaps because response magnitude can be influenced by other factors such as attention. In this study, we measured neural activity in monozygotic twins, using functional magnetic resonance imaging. This allowed us to quantify differences in unique environmental contributions to neural activation evoked by words, pseudowords, consonant strings, and false fonts in the VWFA and striate cortex. The results demonstrate significantly greater effects of unique environment in the word and pseudoword conditions compared to the consonant string and false font conditions both in VWFA and in left striate cortex. These findings provide direct evidence for environmental contributions to the neural architecture for reading, and suggest that learning phonology and/or orthographic patterns plays the biggest role in shaping that architecture

Cognition, Persuasion and Decision Making in Older Consumers

Older adults constitute a rapidly growing demographic segment, but relatively little is known about them within consumer contexts: how they process information, respond to persuasive messages, and make decisions. We discuss extant findings from consumer behavior and related disciplines (e.g., cognitive psychology, neuroscience, social psychology, gerontology) as they pertain to the effects of aging on consumer memory, persuasion and decisionPeer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/47045/1/11002_2005_Article_5903.pd