Exploring Occupational Therapy’s Role in Equine-Assisted Therapy with Veterans

Equine-assisted therapy (EAT) is a treatment that incorporates activities with a horse and the equine environment to reach rehabilitative goals specific to the client\u27s needs and the medical professional\u27s standards of practice (Meregillano, 2004; Path Int, 2021). There are many methods of using a horse in treatment. Therapeutic riding is a component of EAT, as well as horsemanship, groundwork, horse care, and stable management. Hippotherapy is a healthcare professional (OT, PT, SLP) treatment tool that occupational therapists (OT) use the horse\u27s movement to facilitate change (Meregillano, 2004). Some research has demonstrated veterans who work with horses show improvement in quality of life and lower PTSD symptoms, leading to positive changes in self-care, productivity, and leisure (Johnson et al., 2018; Lanning & Krenek, 2013; Olenick et al., 2018). Using the Model of Human Occupation and Person-Environment-Occupation Model, the purpose of this capstone project was to determine OT\u27s role in EAT with veterans to increase occupational engagement in a safe and supportive equine environment, which will allow the veteran to heal. There is a gap in the research related to OT\u27s role in EAT with the veteran population. Using EAT, OTs can individualize treatment sessions to provide benefits in physical, mental, and emotional aspects of veteran lives. This capstone project consisted of three phases of data collection. Phase one was the scoping literature review focused on answering the question: What was the occupational impact of working with equines on the veteran population. Five electronic databases were searched with search terms including equine-assisted therapy and veterans and acceptable related terms such as hippotherapy, therapeutic riding, and EAGALA. Due to the fact, there is little occupational therapy-based research, the OTPF was used as a guide to identifying terms related to OT practice to determine any impact on occupational performance in veterans who participate in EAT. Twelve articles were reviewed after meeting the inclusion criteria. Phase two consisted of a mixed-methods survey to learn the perspective of 11 participants, which included OTs using hippotherapy, veterans, and therapeutic riding staff. Phase three consisted of conducting four informal interviews with stakeholders to perform a needs assessment relative to EAT and veterans. Three main themes were revealed following a thorough thematic analysis process. Veterans who participated in EAT experienced a positive impact on occupational performance. Occupational therapists do have a role in EAT with veterans to contribute to the success of programs and client occupational performance. However, several barriers to practice include funding, reimbursement, and governing equine organization disagreement. This capstone project attempts to promote advocacy for EAT and veterans via a fieldwork proposal to allow opportunities for OT students at USAHS to develop clinical skills in a non-traditional treatment setting with veterans and horses. Further research is needed on the impact of occupations in an equine environment relative to OT practice and research related to finding solutions to the identified barriers found in this project. Advocating to the American Hippotherapy Association to establish supported veteran programming to ensure OTs can use the power of horses to provide care to veterans in need.https://soar.usa.edu/otdcapstonesspring2021/1010/thumbnail.jp

Influence of Pre-Training Predator Stress on the Expression of c-fos mRNA in the Hippocampus, Amygdala, and Striatum Following Long-Term Spatial Memory Retrieval

We have studied the influence of pre-training psychological stress on the expression of c-fos mRNA following long-term spatial memory retrieval. Rats were trained to learn the location of a hidden escape platform in the radial-arm water maze, and then their memory for the platform location was assessed 24 h later. Rat brains were extracted 30 min after the 24-h memory test trial for analysis of c-fos mRNA. Four groups were tested: (1) Rats given standard training (Standard); (2) Rats given cat exposure (Predator Stress) 30 min prior to training (Pre-Training Stress); (3) Rats given water exposure only (Water Yoked); and (4) Rats given no water exposure (Home Cage). The Standard trained group exhibited excellent 24 h memory which was accompanied by increased c-fos mRNA in the dorsal hippocampus and basolateral amygdala (BLA). The Water Yoked group exhibited no increase in c-fos mRNA in any brain region. Rats in the Pre-Training Stress group were classified into two subgroups: good and bad memory performers. Neither of the two Pre-Training Stress subgroups exhibited a significant change in c-fos mRNA expression in the dorsal hippocampus or BLA. Instead, stressed rats with good memory exhibited significantly greater c-fos mRNA expression in the dorsolateral striatum (DLS) compared to stressed rats with bad memory. This finding suggests that stressed rats with good memory used their DLS to generate a non-spatial (cue-based) strategy to learn and subsequently retrieve the memory of the platform location. Collectively, these findings provide evidence at a molecular level for the involvement of the hippocampus and BLA in the retrieval of spatial memory and contribute novel observations on the influence of pre-training stress in activating the DLS in response to long-term memory retrieval

Tianeptine: An Antidepressant with Memory-Protective Properties

The development of effective pharmacotherapy for major depression is important because it is such a widespread and debilitating mental disorder. Here, we have reviewed preclinical and clinical studies on tianeptine, an atypical antidepressant which ameliorates the adverse effects of stress on brain and memory. In animal studies, tianeptine has been shown to prevent stress-induced morphological sequelae in the hippocampus and amygdala, as well as to prevent stress from impairing synaptic plasticity in the prefrontal cortex and hippocampus. Tianeptine also has memory-protective characteristics, as it blocks the adverse effects of stress on hippocampus-dependent learning and memory. We have further extended the findings on stress, memory and tianeptine here with two novel observations: 1) stress impairs spatial memory in adrenalectomized (ADX), thereby corticosterone-depleted, rats; and 2) the stress-induced impairment of memory in ADX rats is blocked by tianeptine. These findings are consistent with previous research which indicates that tianeptine produces anti-stress and memory-protective properties without altering the response of the hypothalamic-pituitary-adrenal axis to stress. We conclude with a discussion of findings which indicate that tianeptine accomplishes its anti-stress effects by normalizing stress-induced increases in glutamate in the hippocampus and amygdala. This finding is potentially relevant to recent research which indicates that abnormalities in glutamatergic neurotransmission are involved in the pathogenesis of depression. Ultimately, tianeptine’s prevention of depression-induced sequelae in the brain is likely to be a primary factor in its effectiveness as a pharmacological treatment for depression

The Temporal Dynamics Model of Emotional Memory Processing: A Synthesis on the Neurobiological Basis of Stress-Induced Amnesia, Flashbulb and Traumatic Memories, and the Yerkes-Dodson Law

We have reviewed research on the effects of stress on LTP in the hippocampus, amygdala and prefrontal cortex (PFC) and present new findings which provide insight into how the attention and memory-related functions of these structures are influenced by strong emotionality. We have incorporated the stress-LTP findings into our “temporal dynamics” model, which provides a framework for understanding the neurobiological basis of flashbulb and traumatic memories, as well as stress-induced amnesia. An important feature of the model is the idea that endogenous mechanisms of plasticity in the hippocampus and amygdala are rapidly activated for a relatively short period of time by a strong emotional learning experience. Following this activational period, both structures undergo a state in which the induction of new plasticity is suppressed, which facilitates the memory consolidation process. We further propose that with the onset of strong emotionality, the hippocampus rapidly shifts from a “configural/cognitive map” mode to a “flashbulb memory” mode, which underlies the long-lasting, but fragmented, nature of traumatic memories. Finally, we have speculated on the significance of stress-LTP interactions in the context of the Yerkes-Dodson Law, a well-cited, but misunderstood, century-old principle which states that the relationship between arousal and behavioral performance can be linear or curvilinear, depending on the difficulty of the task

PERMISSIVE INFLUENCE OF STRESS IN THE EXPRESSION OF A U-SHAPED RELATIONSHIP BETWEEN SERUM CORTICOSTERONE LEVELS AND SPATIAL MEMORY ERRORS IN RATS

The relationship between glucocorticoids (GCs) and memory is complex, in that memory impairments can occur in response to manipulations that either increase or decrease GC levels. We investigated this issue by assessing the relationship between serum corticosterone (the primary rodent GC) and memory in rats trained in the radial arm water maze, a hippocampus-dependent spatial memory task. Each day, rats learned a new location of the hidden escape platform and then 30 min later their memory of the location of the platform was tested. Under control conditions, well-trained rats had excellent spatial memory and moderately elevated corticosterone levels (~26 μg/dl versus a baseline of ~2 μg/dl). Their memory was impaired when corticosterone levels were either reduced by metyrapone (a corticosterone synthesis inhibitor) or increased by acute stress (predator exposure), forming an overall U-shaped relationship between corticosterone levels and memory. We then addressed whether there was a causal relationship between elevated corticosterone levels and impaired memory. If elevated corticosterone levels were a sufficient condition to impair memory, then exogenously administered corticosterone, alone, should have impaired performance. However, we found that spatial memory was not impaired in corticosterone-injected rats that were not exposed to the cat. This work demonstrates that an intermediate level of corticosterone correlated with optimal memory, and either a decrease or an increase in corticosterone levels, in conjunction with strong emotionality, impaired spatial memory. These findings indicate that fear-provoking conditions, which are known to engage the amygdala, interact with stress levels of corticosterone to influence hippocampal functioning

Mn local moments prevent superconductivity in iron-pnictides Ba(Fe 1-x Mn x)2As2

75As nuclear magnetic resonance (NMR) experiments were performed on Ba(Fe1-xMnx)2As2 (xMn = 2.5%, 5% and 12%) single crystals. The Fe layer magnetic susceptibility far from Mn atoms is probed by the75As NMR line shift and is found similar to that of BaFe2As2, implying that Mn does not induce charge doping. A satellite line associated with the Mn nearest neighbours (n.n.) of 75As displays a Curie-Weiss shift which demonstrates that Mn carries a local magnetic moment. This is confirmed by the main line broadening typical of a RKKY-like Mn-induced staggered spin polarization. The Mn moment is due to the localization of the additional Mn hole. These findings explain why Mn does not induce superconductivity in the pnictides contrary to other dopants such as Co, Ni, Ru or K.Comment: 6 pages, 7 figure

BaseSAFE: Baseband SAnitized Fuzzing through Emulation

Rogue base stations are an effective attack vector. Cellular basebands represent a critical part of the smartphone's security: they parse large amounts of data even before authentication. They can, therefore, grant an attacker a very stealthy way to gather information about calls placed and even to escalate to the main operating system, over-the-air. In this paper, we discuss a novel cellular fuzzing framework that aims to help security researchers find critical bugs in cellular basebands and similar embedded systems. BaseSAFE allows partial rehosting of cellular basebands for fast instrumented fuzzing off-device, even for closed-source firmware blobs. BaseSAFE's sanitizing drop-in allocator, enables spotting heap-based buffer-overflows quickly. Using our proof-of-concept harness, we fuzzed various parsers of the Nucleus RTOS-based MediaTek cellular baseband that are accessible from rogue base stations. The emulator instrumentation is highly optimized, reaching hundreds of executions per second on each core for our complex test case, around 15k test-cases per second in total. Furthermore, we discuss attack vectors for baseband modems. To the best of our knowledge, this is the first use of emulation-based fuzzing for security testing of commercial cellular basebands. Most of the tooling and approaches of BaseSAFE are also applicable for other low-level kernels and firmware. Using BaseSAFE, we were able to find memory corruptions including heap out-of-bounds writes using our proof-of-concept fuzzing harness in the MediaTek cellular baseband. BaseSAFE, the harness, and a large collection of LTE signaling message test cases will be released open-source upon publication of this paper

Exogenous Ketones Lower Blood Glucose Level in Rested and Exercised Rodent Models.

Diseases involving inflammation and oxidative stress can be exacerbated by high blood glucose levels. Due to tight metabolic regulation, safely reducing blood glucose can prove difficult. The ketogenic diet (KD) reduces absolute glucose and insulin, while increasing fatty acid oxidation, ketogenesis, and circulating levels of β-hydroxybutyrate (βHB), acetoacetate (AcAc), and acetone. Compliance to KD can be difficult, so alternative therapies that help reduce glucose levels are needed. Exogenous ketones provide an alternative method to elevate blood ketone levels without strict dietary requirements. In this study, we tested the changes in blood glucose and ketone (βHB) levels in response to acute, sub-chronic, and chronic administration of various ketogenic compounds in either a post-exercise or rested state. WAG/Rij (WR) rats, a rodent model of human absence epilepsy, GLUT1 deficiency syndrome mice (GLUT1D), and wild type Sprague Dawley rats (SPD) were assessed. Non-pathological animals were also assessed across different age ranges. Experimental groups included KD, standard diet (SD) supplemented with water (Control, C) or with exogenous ketones: 1, 3-butanediol (BD), βHB mineral salt (KS), KS with medium chain triglyceride/MCT (KSMCT), BD acetoacetate diester (KE), KE with MCT (KEMCT), and KE with KS (KEKS). In rested WR rats, the KE, KS, KSMCT groups had lower blood glucose level after 1 h of treatment, and in KE and KSMCT groups after 24 h. After exercise, the KE, KSMCT, KEKS, and KEMCT groups had lowered glucose levels after 1 h, and in the KEKS and KEMCT groups after 7 days, compared to control. In GLUT1D mice without exercise, only KE resulted in significantly lower glucose levels at week 2 and week 6 during a 10 weeks long chronic feeding study. In 4-month and 1-year-old SPD rats in the post-exercise trials, blood glucose was significantly lower in KD and KE, and in KEMCT groups, respectively. After seven days, the KSMCT group had the most significantly reduced blood glucose levels, compared to control. These results indicate that exogenous ketones were efficacious in reducing blood glucose levels within and outside the context of exercise in various rodent models of different ages, with and without pathology

GaP-ZnS Multilayer Films:Visible-Light Photoelectrodes by Interface Engineering

In the field of solar water splitting, searching for and modifying bulk compositions have been the conventional approaches to enhancing visible-light activity. In this work, manipulation of heterointerfaces in ZnS-GaP multilayer films is demonstrated as a successful alternative approach to achieving visible-light-active photoelectrodes. The photocurrent measured under visible light increases with the increasing number of interfaces for ZnS-GaP multilayer films with the same total thickness, indicating it to be a predominantly interface-driven effect. The activity extends to long wavelengths (650 nm), much longer than those expected for pure ZnS and also longer than those previously reported for GaP. Density functional theory calculations of ZnS-GaP multilayers predict the presence of electronic states associated with atoms at the interfaces between ZnS and GaP that are different from those found within the layers away from the interfaces; these states, formed due to unique bonding environments found at the interfaces, lead to a lowering of the band gap and hence the observed visible-light activity. The presence of these electronic states attributed to the interfaces is confirmed by depth-resolved X-ray photoelectron spectroscopy. Thus, we show that interface engineering is a promising route for overcoming common deficiencies of individual bulk materials caused by both wide band gaps and indirect band gaps and hence enhancing visible-light absorption and photoelectrochemical performance