Wind oscillation analysis of a suspension bridge coupled with CFD

This study conducted a CFD-2D coupled analysis of a suspension bridge subjected to wind loads. Previous studies found that rotational oscillation was due to differences in the restoring force at hanger cables and could generate torsional oscillations. However, due to uncertain external force terms, the previous studies could not be applied to analyze actual structures. To enable application in a real design process, this study proposed a methodology for determining the external force terms. The external force terms were determined with CFD, and a moment force term was added to equations of motion derived from dynamic equilibrium conditions. All constants and properties were calculated from an assumed cross section of superstructure. This methodology can be used not only to avoid torsional resonance but also in preliminary analysis in the bridge design stage

Wind oscillation analysis of a suspension bridge coupled with CFD

This study conducted a CFD-2D coupled analysis of a suspension bridge subjected to wind loads. Previous studies found that rotational oscillation was due to differences in the restoring force at hanger cables and could generate torsional oscillations. However, due to uncertain external force terms, the previous studies could not be applied to analyze actual structures. To enable application in a real design process, this study proposed a methodology for determining the external force terms. The external force terms were determined with CFD, and a moment force term was added to equations of motion derived from dynamic equilibrium conditions. All constants and properties were calculated from an assumed cross section of superstructure. This methodology can be used not only to avoid torsional resonance but also in preliminary analysis in the bridge design stage

A case report of chronic granulomatous disease presenting with aspergillus pneumonia in a 2-month old girl

Chronic granulomatous disease (CGD) is an uncommon inherited disorder caused by mutations in any of the genes encoding subunits of the superoxide-generating phagocyte NADPH oxidase system, which is essential for killing catalase producing bacteria and fungi, such as Aspergillus species, Staphylococcus aureus, Serratia marcescens, Nocardia species and Burkholderia cepacia. In case of a history of recurrent or persistent infections, immune deficiency should be investigated. Particularly, in the case of uncommon infections such as aspergillosis in early life, CGD should be considered. We describe here a case of CGD that presented with invasive pulmonary aspergillosis in a 2-month-old girl. We confirmed pulmonary aspergillosis noninvasively through a positive result from the culture of bronchial alveolar lavage fluid, positive serological test for Aspergillus antigen and radiology results. She was successfully treated with Amphotericin B and recombinant IFN-γ initially. Six weeks later after discharge, she was readmitted for pneumonia. Since there were infiltrates on the right lower lung, which were considered as residual lesions, voriconazole therapy was initiated. She showed a favorable response to the treatment and follow-up CT showed regression of the pulmonary infiltrates

A Case of Histiocytic Sarcoma Presenting with Primary Bone Marrow Involvement

Histiocytic sarcoma (HS) is a very rare neoplasm that often shows an aggressive clinical course and systemic symptoms, such as fever, weight loss, adenopathy, hepatosplenomegaly and pancytopenia. It may present as localized or disseminated disease. We describe here a 63-yr-old male who manifested systemic symptoms, including fever, weight loss and generalized weakness. Abdominal and chest computed tomography failed to show specific findings, but there was suspicion of multiple bony changes at the lumbar spine. Fusion whole body positron emission tomography, bone scan and lumbar spine magnetic resonance imaging showed multiple bone lesions, suggesting a malignancy involving the bone marrow (BM). Several BM and bone biopsies were inconclusive for diagnosis. Necropsy showed replacement of the BM by a diffuse proliferation of neoplastic cells with markedly increased cellularity (95%). The neoplastic cells were positive for lysozyme and CD68, but negative for T- and B-cell lineage markers, and megakaryocytic, epithelial, muscular and melanocytic markers. Morphologic findings also distinguished it from other dendritic cell neoplasms