A Clinical Survey Efficacy Of Frankincense In Acute Ischemic Stroke

Background &Aims: Ischemic stroke is the most common cause of stroke ,and paralysis and movement disorders are the most symptoms of stroke. Therefore, it is important to find a method for improving the disorders. This study aimed to examine the clinical efficacy of frankincense in patients with the acute ischemic stroke. Methods: In this clinical trial, 60 patients with ischemic stroke were randomly allocated into the treatment and control groups (n=30). In the treatment group, in addition to routine treatment of stroke, four capsules containing 500 mg powdered frankincense was given daily , but in the control group, was performed only the treatment of stroke (no frankincense). The treatment lasted for 1 month. The NIHSS scale (for assessment of speech and muscle strength) at the beginning, the seventh day and end of the study for each patient was completed. Statistical analysis was performed using independent t-test, chi-square, mann withney in SPSS software. Results: Results showed that only improvement of muscle strength in patients left limb increased significantly in stage II in the treatment group than the control group. Conclusion: Adding frankincense to treatment of patients with stroke can be effective on improvement muscle strength in patients with muscle weakness and non-dominant side in acute neurological disorders. While that is not effective on improving muscle strength of the right limb or speech

A Clinical Survey of Efficacy of Frankincense in Acute Ischemic Stroke

Introduction: Ischemic stroke is the most common cause of stroke, paralysis and movement disorders are the most symptoms of stroke. Therefore, it is important to find a method for improving the disorders. This study aimed to examine the clinical efficacy of frankincense in patients with the acute ischemic stroke. Materials & methods: In this clinical trial, 06 patients with ischemic stroke were randomly allocated into the treatment and control groups (n=06). In the treatment group, in addition to routine treatment of stroke, four capsules containing 522 mg powdered frankincense were given each day, but in the control group, were performed only the treatment of stroke (no frankincense) was performed. The treatment lasted for 1 month. The NIHSS scale (for assessment of speech and muscle strength) at the beginning, the seventh day and the end of the study for each patient was completed. Statistical analysis was performed using independent t-test, chisquare, and Mann withney in SPSS software. Findings: Results showed that only improvement of muscle strength in patients left limb increased significantly in stage II in the treatment group than the control group. Discussion & conclusions: Adding frankincense to treatment of patients with stroke can be effective on improvement muscle strength in patients with muscle weakness and non-dominant side in acute neurological disorders while that is not effective on improving muscle strength of the right limb or speech

A macro-and microscopic local effect of silver nanoparticles on skin wound healing and some biochemical parameters of blood in mice

زمینه و هدف: در حال حاضر نقره و ترکیبات آن به عنوان یک راه حل مناسب برای درمان عفونت در سوختگی ها، زخم های باز و زخم های مزمن به کار برده می شوند. این مطالعه با هدف بررسی اثر موضعی نانوذرات نقره بر روی پارامترهای بیوشیمایی خون و بافت کلیه در هنگام ترمیم زخم در موش سفید آزمایشگاهی طراحی و اجرا شد. روش بررسی: در این مطالعه تجربی، 50 سر موش بالب سی (Balb/c) ماده در حدود 4 هفته (با وزن 3±2/24 گرم) در دو گروه 25 تایی (تیمار و کنترل) مورد بررسی قرار گرفتند. پس از ایجاد زخم یکسان در همه حیوانات سطح زخم گروه تیمار با µl 50 محلول ppm 10 و برای گروه کنترل با همان مقدار آب مقطر تیمار شد. در روزهای دوم، هفتم، چهاردهم و بیست و یکم نمونه گیری بافت از زخم پوست و نمونه گیری از خون انجام شد و مساحت زخم برای هر دو گروه در روزهای متوالی اندازه گیری شد. یافته ها: درصد بهبود زخم در گروه تیمار نسبت به گروه کنترل به طور معنی داری بیشتر بود. به طوری که در گروه تیمار بهبود نهایی در زمان 82/0±14روز و در گروه کنترل بهبودی نهایی در زمان 03/1±75/20 روز خاتمه یافت (05/0>P). متوسط پتاسیم و نیتروژن اوره خون در بین گروه ها تفاوت معنی داری نشان داد (05/0>P). نتیجه گیری: نتایج نشان داد که محلول ppm 10 نانوذرات نقره علاوه بر تسریع بهبود زخم، بر روی برخی پارامترهای خون به طور معنی داری اثرات منفی می گذارد؛ لذا علاوه بر اثرات سودمند خود دارای اثرات مضر نیز می باشد و باید در مصرف آن احتیاط لازم را مبذول نمود

Subacute dermal toxicity investigation of nanosilver on serum chemical biomarkers in male mice

Abstract Objective(s): Nanosilver is one of the most widely used nanomaterials due to its strong antimicrobial activity. Thus, because of increasing potential for exposure of human to nanosilver, there is an increasing concern about possible side effects of these nanoparticles. In this study, we tested the potential dermal toxicity of nanosilver bandage on serum chemical biomarkers in mice. Materials and Methods: In this study, 20 male BALB/c mice were randomly allocated into the treatment and control groups (n=10). After general anesthesia and shaving the back of all animals in near the vertebral column, in the nanosilver group, a volume of 50μl of 10 μg/ml of nanosilver solution (40 nm), and in the control group the same amount of distilled water was added to the sterile bandage of mice, then the bandages were fixed on the skin surface with cloth glue. After 3 and 7 days, the bandages were opened and serum levels of blood urea nitrogen (BUN), creatinine (Cr), alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were measured by using standard kits for two groups of mice. Results: In treatment group, a significant increase in ALT, AST and BUN levels were observed compared with control group during experiment periods (p0.05). Conclusion: The present results indicated that the dermal absorption of 10 μg/ml nanosilver (40 nm) can lead to hepatotoxicity and renal toxicity in mice

Evaluation of Dermal Absorption of Nanosilver Particles on the Renal Function Parameters in Male Mice

Background: Nanosilver is one of the most widely used nanomaterials in consumer products. However, little attention was paid to the dermal toxic of These particles on human health. This study aimed to examine the effect of nanosilver dermal absorption on renal function parameters. Materials and Methods: In this experimental study, 40 male BALB/c mice were randomly divided into 4 groups of 10 (nanosilver, positive control, sham control and negative control groups). After general anesthesia and shaving the back of all animals in near the vertebral column, the Bandage surface was treated in the nanosilver group, with a volume of 50 microliters of the nanosilver solution (100 &micro;g/ml) ,and in the positive control group with the same amount of silver nitrate solution (100 &micro;g/ml), and in the sham control group with the same amount of distilled water, then the Bandages were fixed in the skin surface, but the negative control group was without treatment and bandage. After 3 and 7 days, the bandages had opened, and the serum levels of Creatinine (Cr) and Blood Urea Nitrogen (BUN) were measured. Results: On 3 and 7 days, in nanosilver group, creatinine did not change significantly(p>0.05), but BUN levels showed significant increase compared to other groups (p<0.05). In addition, there wasn&rsquo;t significant changes in the renal function parameters in 7-day compared to 3-day (p>0.05). Conclusion: In this study, a significant increase in BUN of nanosilver group can be indicate kidney dysfunction, therefore nanosilver dermal absorption can be have the toxic effects on the kidney function

Sliver nanoparticles accelerate skin wound healing in mice (Mus musculus) through suppression of innate immune system

  Objective(s): This study aimed to find the effects of silver nanoparticles (Ag-NPs) (40 nm) on skin wound healing in mice Mus musculus when innate immune system has been suppressed.   Materials and Methods: A group of 50 BALB/c mice of about 8 weeks (weighting 24.2±3.0 g) were randomly divided into two groups: Ag-NPs and control group, each with 25 mice. Once a day at the same time, a volume of 50 microliters from the nanosilver solution (10ppm) was applied to the wound bed in the Ag-NPs group while in the untreated (control) group no nanosilver solution was used but the wound area was washed by a physiological solution. The experiment lasted for 14. Transforming growth factor beta (TGF-β), complement component C3, and two other immune system factors involving in inflammation, namely C-reactive protein (CRP) and rheumatoid factor (RF) in sera of both groups were assessed and then confirmed by complement CH50 level of the blood. Results: The results show that wound healing is a complex process involving coordinated interactions between diverse immunological and biological systems and that Ag-NPs significantly accelerated wound healing and reduce scar appearance through suppression of immune system as indicated by decreasing levels of all inflammatory factors measured in this study. Conclusion: Exposure of mice to Ag-NPs can result in significant changes in innate immune function at the molecular levels. The study improves our understanding of nanoparticle interaction with components of the immune system and suggests that Ag-NPs have strong anti-inflammatory effects on skin wound healing and reduce scarring

Histopathological effects of nanosilver (Ag-NPs) in liver after dermal exposure during wound healing

  Objective(s): With the advent of nanotechnology, significant progress has been made in the area of nanoscale materials such as nanosilver (Ag-Nps). These nanoparticles have a wide range of applications and been used for antimicrobial purposes for more than a century. However, little attention has been paid to the toxicity of nanosilver wound dressing. This study was designed to investigate the possible histopathological toxicity of Ag-NPs in liver of mice during wound healing.     Materials and Methods:   A group of 50 female BALB/c mice of about 8 weeks were randomly divided into two groups: Ag-NPs and control groups (n=25). After creating similar wound on the backs of all animals, the wound bed was treated in Ag-NPs group, with a volume of 50 microliters of the nanosilver solution (10ppm) ,and in control group, with the same amount of distilled water. The experiment lasted for 14 days. Histopathaological samplings of liver were conducted on days 2, 7 and 14 of the experiment.   Results: Histopathological studies demonstrated time-dependent changes in mice liver treated with Ag-NPs compared to control group. Some changes include dilation in central venous, hyperemia, cell swelling, increase of Kupffer and inflammatory cells. Conclusion: This study suggests that use of nanosilver for wound healing may cause a mild toxicity, as indicated by time-dependent toxic responses in liver tissue. However, this issue will have to be considered more extensively in further studies

Exposure to the COVID-19 news on social media and consequent psychological distress and potential behavioral change

Abstract Exposure to coronavirus disease 2019 (COVID-19) news pandemic is inevitable. This study aimed to explore the association between exposure to COVID-19 news on social media and feeling of anxiety, fear, and potential opportunities for behavioral change among Iranians. A telephone-based survey was carried out in 2020. Adults aged 18 years and above were randomly selected. A self-designed questionnaire was administered to collect information on demographic variables and questions to address exposure to news and psychological and behavioral responses regarding COVID-19. A multivariate logistic regression analysis was performed to assess the relationship between anxiety, fear, behavioral responses, and independent variables, including exposure to news. In all, 1563 adults participated in the study. The mean age of respondents was 39.17 ± 13.5 years. Almost 55% of participants reported moderate to high-level anxiety, while fear of being affected by COVID-19 was reported 54.1%. Overall 88% reported that they had changed their behaviors to some extent. Exposure to the COVID-19 news on social media was the most influencing variable on anxiety (OR 2.21, 95% CI 1.62–3.04; P < 0.0001), fear (OR 1.95, 95% CI 1.49–2.56; P < 0.0001), and change in health behaviors (OR 2.02, 95% CI 1.28–3.19; P = 0.003) in the regression model. The fear of being infected by the COVID19 was associated with the female gender and some socioeconomic characteristics. Although exposure to the COVID-19 news on social media seemed to be associated with excess anxiety and fear, it also, to some extent, had positively changed people’s health behaviors towards preventive measures