Evaluation of medical practitioners’ knowledge and attitude towards periodontal health and associated factors

Background and Aims: Considering the prevalence of periodontal disease in Iranian adults and its impact on general health and the role of medical practitioners, the purpose of the present study was to determine physician’s knowledge and attitude towards periodontal health. Materials and Methods: A cross-sectional study was conducted in Tehran in 2019 and after getting informed consent, a valid and reliable questionnaire was provided to medical practitioners in a continuing education course. Data were analyzed using the SPSS26 software. Results: In total 170 subjects (response rate=95%) responded. The mean scores of knowledge and attitude towards periodontal health were 4.1 (maximum score of 6) and 51.9 (maximum score of 65), respectively. Work experience (P=0.022) and period of time after graduation (P=0.007) had a positive and significant relationship with participants' knowledge. Also, gender (P=0.012), work experience (P=0.002), period after graduation (P=0.005) and practitioner’s workplace (P=0.001) were significantly associated with their attitudes. The results showed that women had a better attitude towards prevention of gum disease. Conclusion: In the present study, medical practitioners’ knowledge was good towards description of healthy periodontium and the first sign of periodontal diseas. Also, their attitudes regarding the importance of oral and dental diseases and its impact on social activities were appropriate. The results of the present study showed more emphasis is needed on delivering relevant dental education in medical curriculum

Comparison of Common Monogenic Defects in a Large Predominantly Antibody Deficiency Cohort

Background: Predominantly antibody deficiencies (PADs) are the most common primary immunodeficiencies, characterized by hypogammaglobulinemia and inability to generate effective antibody responses. Objective: We intended to report most common monogenic PADs and to investigate how patients with PAD who were primarily diagnosed as suffering from agammaglobulinemia, hyper-IgM (HIgM) syndrome, and common variable immunodeficiency (CVID) have different clinical and immunological findings. Methods: Stepwise next-generation sequencing and Sanger sequencing were performed for confirmation of the mutations in the patients clinically diagnosed as suffering from agammaglobulinemia, HIgM syndrome, and CVID. Results: Among 550 registered patients, the predominant genetic defects associated with agammaglobulinemia (48 Bruton's tyrosine kinase [BTK] and 6 μ heavy chain deficiencies), HIgM syndrome (21 CD40 ligand and 7 activation-induced cytidine deaminase deficiencies), and CVID (17 lipopolysaccharides-responsive beige-like anchor deficiency and 12 atypical Immunodeficiency, Centromeric instability, and Facial dysmorphism syndromes) were identified. Clinical disease severity was significantly higher in patients with μ heavy chain and CD40 ligand mutations compared with patients with BTK (P = .003) and activation-induced cytidine deaminase (P = .009) mutations. Paralysis following live polio vaccination was considerably higher in patients with μ heavy chain deficiency compared with BTK deficiency (P < .001). We found a genotype-phenotype correlation among patients with BTK mutations regarding clinical manifestation of meningitis and chronic diarrhea. Surprisingly, we noticed that first presentations in most patients with Immunodeficiency, Centromeric instability, and Facial dysmorphism were respiratory complications (P = .008), whereas first presentations in patients with lipopolysaccharides-responsive beige-like anchor deficiency were nonrespiratory complications (P = .008). Conclusions: This study highlights similarities and differences in the clinical and genetic spectrum of the most common PAD-associated gene defects. This comprehensive comparison will facilitate clinical decision making, and improve prognosis and targeted treatment

Comparison of Common Monogenic Defects in a Large Predominantly Antibody Deficiency Cohort

Predominantly antibody deficiencies (PADs) are the most common primary immunodeficiencies, characterized by hypogammaglobulinemia and inability to generate effective antibody responses