Time Sensitive Parameters of Immune Reconstitution Measured Between Day 100 and 1 Year Predict Survival After Unrelated Cord Blood Transplant (UCBT): The Dynamic Impact of Dendritic Cells, Tregs, and Thymic Recovery

Digitalitzat per Artypla

Tunneling of massive and charged particles from noncommutative Reissner-Nordstr\"{o}m black hole

Massive charged and uncharged particles tunneling from commutative Reissner-Nordstrom black hole horizon has been studied with details in literature. Here, by adopting the coherent state picture of spacetime noncommutativity, we study tunneling of massive and charged particles from a noncommutative inspired Reissner-Nordstrom black hole horizon. We show that Hawking radiation in this case is not purely thermal and there are correlations between emitted modes. These correlations may provide a solution to the information loss problem. We also study thermodynamics of noncommutative horizon in this setup.Comment: 10 pages, 2 figure

Dietary docosahexaenoic acid supplementation modulates hippocampal development in the pemt-/- mouse

The development of fetal brain is influenced by nutrients such as docosahexaenoic acid (DHA, 22:6) and choline. Phosphatidylethanolamine-N-methyltransferase (PEMT) catalyzes the biosynthesis of phosphatidylcholine from phosphatidylethanolamine enriched in DHA and many humans have functional genetic polymorphisms in the PEMT gene. Previously, it was reported that Pemt-/- mice have altered hippocampal development. The present study explores whether abnormal phosphatidylcholine biosynthesis causes altered incorporation of DHA into membranes, thereby influencing brain development, and determines whether supplemental dietary DHA can reverse some of these changes. Pregnant C57BL/6 wild type (WT) and Pemt-/- mice were fed a control diet, or a diet supplemented with 3 g/kg of DHA, from gestational day 11 to 17. Brains from embryonic day 17 fetuses derived from Pemt-/- dams fed the control diet had 25-50% less phospholipid-DHA as compared with WT (p < 0.05). Also, they had 60% more neural progenitor cell proliferation (p < 0.05), 60% more neuronal apoptosis (p < 0.01), and 30% less calretinin expression (p < 0.05; a marker of neuronal differentiation) in the hippocampus compared with WT. The DHA-supplemented diet increased fetal brain Pemt-/- phospholipid-DHA to WT levels, and abrogated the neural progenitor cell proliferation and apoptosis differences. Although this diet did not change proliferation in the WT group, it halved the rate of apoptosis (p < 0.05). In both genotypes, the DHA-supplemented diet increased calretinin expression 2-fold (p < 0.05). These results suggest that the changes in hippocampal development in the Pemt-/- mouse could be mediated by altered DHA incorporation into membrane phospholipids, and that maternal dietary DHA can influence fetal brain development

Hawking Radiation and Tunneling Mechanism for a New Class of Black Holes in Einstein-Gauss-Bonnet Gravity

We study the Hawking radiation in a new class of black hole solutions in the Einstein-Gauss-Bonnet theory. The black hole has been argued to have vanishing mass and entropy, but finite Hawking temperature. To check if it really emits radiation, we analyse the Hawking radiation using the original method of quantization of scalar field in the black hole background and the quantum tunneling method, and confirm that it emits radiation at the Hawking temperature. A general formula is derived for the Hawking temperature and backreaction in the tunneling approach. Physical implications of these results are discussed.Comment: 12 pages, v2: Title slightly changed. Motivation and discussions are elaborated, v3: typos corrected to match the published versio

Analytical studies of Hawking radiation and quasinormal modes in rotating linear dilatonic black hole

The rotating linear dilatonic black hole is an asymptotically non-flat solution to Einstein-Maxwell-Dilaton-Axion gravity theory due to the existence of non-trivial matter fields. We have analytically studied the wave equation of scalar field in this background and shown that the radial wave equation can be solved in terms of hypergeometric function. By determining the ingoing and the outgoing fluxes at the asymptotic infinity, we have found the analytical expressions for reflection coefficient and greybody factor for certain scalar modes. In the high frequency regime, we obtain the Hawking temperature by comparing the blackbody spectrum with the radiation spectrum resulting from reflection coefficient. It is shown that the Hawking temperature, which depends only on the linear dilatonic background parameter, does not agree with the temperature calculated from surface gravity. At last, the quasinormal modes of scalar field perturbation are presented, which shows that the rotating linear dilationic black hole is unstable for certain modes apart from the superradiant modes.Comment: 7 pages, 2 figures Comments are welcom

Recent Randomized Trials of Antithrombotic Therapy for Patients With COVID-19: JACC State-of-the-Art Review

Endothelial injury and microvascular/macrovascular thrombosis are common pathophysiological features of coronavirus disease-2019 (COVID-19). However, the optimal thromboprophylactic regimens remain unknown across the spectrum of illness severity of COVID-19. A variety of antithrombotic agents, doses, and durations of therapy are being assessed in ongoing randomized controlled trials (RCTs) that focus on outpatients, hospitalized patients in medical wards, and patients critically ill with COVID-19. This paper provides a perspective of the ongoing or completed RCTs related to antithrombotic strategies used in COVID-19, the opportunities and challenges for the clinical trial enterprise, and areas of existing knowledge, as well as data gaps that may motivate the design of future RCTs. © 2021 American College of Cardiology Foundatio

Evaluation of sesamum gum as an excipient in matrix tablets

In developing countries modern medicines are often beyond the affordability of the majority of the population. This is due to the reliance on expensive imported raw materials despite the abundance of natural resources which could provide an equivalent or even an improved function. The aim of this study was to investigate the potential of sesamum gum (SG) extracted from the leaves of Sesamum radiatum (readily cultivated in sub-Saharan Africa) as a matrix former. Directly compressed matrix tablets were prepared from the extract and compared with similar matrices of HPMC (K4M) using theophylline as a model water soluble drug. The compaction, swelling, erosion and drug release from the matrices were studied in deionized water, 0.1 N HCl (pH 1.2) and phosphate buffer (pH 6.8) using USP apparatus II. The data from the swelling, erosion and drug release studies were also fitted into the respective mathematical models. Results showed that the matrices underwent a combination of swelling and erosion, with the swelling action being controlled by the rate of hydration in the medium. SG also controlled the release of theophylline similar to the HPMC and therefore may have use as an alternative excipient in regions where Sesamum radiatum can be easily cultivated