The Proportion of Women Who Have a Breast 4 Years after Breast Cancer Surgery: A Population-Based Cohort Study.

BACKGROUND: There are numerous pathways in breast cancer treatment, many of which enable women to retain a breast after treatment. We evaluated the proportion of women who have a breast, either through conserving surgery (BCS) or reconstruction, at 4-years after diagnosis, and how this varied by patient group. METHODS AND FINDINGS: We identified women with breast cancer who underwent initial BCS or mastectomy in English National Health Service (NHS) hospitals between January 2008 and December 2009 using the Hospital Episode Statistics (HES) database. Women were assigned into one of four patient groups depending on their age at diagnosis and presence of comorbidities. The series of breast cancer procedure (BCS, mastectomy, immediate, or delayed reconstruction) undergone by each women was identified over four years, and the proportion of women with a breast calculated. Variation was examined across patient groups, and English Cancer Networks. Between 2008 and 2009, 60,959 women underwent BCS or mastectomy. The proportion with a breast at 4 years was 79.3%, and 64.0%, in women less than 70 years without, and with comorbidities. Whilst in women aged 70 and over without, and with comorbidities, proportions were 52.6%, and 38.2%, respectively. Comorbidities were associated with lower proportions of BCS, but had little effect on reconstruction rates unlike age. Networks variation of 15% or more was found within each patient group, and Cancer Networks tended to have either a high or low proportion across all four patient groups. However, while 14% of women under 70 years had undergone reconstruction, less than 2% of women aged 70 or more had this treatment option. CONCLUSION: The proportion of women diagnosed with breast cancer who retain a breast at 4 years is strongly associated with age, and presence of comorbidities. There was significant variation between Cancer Networks indicating that women's experience in England was dependent on their geographical location of treatment

Effect of Gymnema montanum Leaves on Serum and Tissue Lipids in Alloxan Diabetic Rats

The effect of Gymnema montanum leaves on alloxaninduced hyperlipidemia was studied in male Wistar rats. Ethanolic extract of G. montanum leaves was administered orally and different doses of the extract on blood glucose, serum and tissue lipids, hexokinase, glucose-6-phosphatase, thiobarbituric acid–reactive substances (TBARS), hydroperoxides, and glutathione in alloxan-induced diabetic rats were studied. G. montanum leaf extract (GLEt) at doses of 50, 100, 200 mg/kg body weight for 3 weeks suppressed the elevated blood glucose and lipid levels in diabetic rats. GLEt at 200 mg/kg body weight was found to be comparable to glibenclamide, a reference drug. These data indicate that G. montanum represents an effective antihyperglycemic and antihyperlipidemic adjunct for the treatment of diabetes and a potential source of discovery of new orally active agent for future therapy

Mills hemiparetic or hemiplegic variant of amyotrophic lateral sclerosis

Mills hemiplegic variant of Amyotrophic lateral sclerosis (ALS) is a gradually progressive, spastic ascending or descending hemiparesis or hemiplegia without any sensory involvement. Authors presented a 47 years old female with history of gradually progressive left sided wasting of muscles including the tongue, left hemiparesis along with dysarthria and fasciculation’s of tongue and left sided muscles with left sided cortico-spinal tract signs of 2 years duration. There were no sensory as well as bowel bladder involvement. Her cognition was intact. Relevant blood and CSF examinations were within normal limit. MRI Brain and whole spine were unremarkable. Nerve conduction study was essentially normal. Electromyography(EMG) showed chronic denervation potentials which is in accordance to Revised El Escorial criteria, 2015 for the diagnosis of this extremely uncommon entity- Mills hemiplegic variant of ALS. The major challenge in diagnosis of this disease entity is to exclude other diseases/disorders that may mimic its symptomatology

Antihyperlipidemic and antiperoxidative effect of Diasulin, a polyherbal formulation in alloxan induced hyperglycemic rats

BACKGROUND: This study was undertaken to investigation the effect of Diasulin, a poly herbal drug composed of ethanolic extract of ten medicinal plants on blood glucose, plasma insulin, tissue lipid profile, and lipidperoxidation in alloxan induced diabetes. METHODS: Ethanolic extract of Diasulin a, poly herbal drug was administered orally (200 mg/kg body weight) for 30 days. The different doses of Diasulin on blood glucose and plasma insulin in diabetic rats were studied and the levels of lipid peroxides [TBARS, and Hydroperoxide] and tissue lipids [cholesterol, triglyceride, phospholipides and free fatty acids] were also estimated in alloxan induced diabetic rats. The effects were compared with glibenclamide. RESULT: Treatment with Diasulin and glibenclamide resulted in a significant reduction of blood glucose and increase in plasma insulin. Diasulin also resulted in a significant decrease in tissue lipids and lipid peroxide formation. The effect produced by Diasulin was comparable with that of glibenclamide. CONCLUSION: The decreased lipid peroxides and tissue lipids clearly showed the antihyperlipidemic and antiperoxidative effect of Diasulin apart from its antidiabetic effect

Feeding emitters for microirrigation with a digestate liquid fraction up to 25% dilution did not reduce their performance

Irrigation with wastewater can strongly contribute to the reduction of water abstraction in agriculture with an especial interest in arid and semiarid areas. However, its use can have drawbacks to both soil and micro-irrigation systems, especially when the total solids in the wastewater are high, such as in digestate liquid fractions (DLF) from plant material. The aim of this study was thus to evaluate the performances of a serpentine shaped micro-emitter injected with a hydrocyclone filtered DLF (HF-DLF) from corn + barley biomass and evaluate the traits of the liquid released within a 8-h irrigation cycle. HF-DLF was injected at 10%, 25%, and 50% dilution compared to tap water (at pH = 7.84) and the system performances were measured. No clogging was found, which likely depended on both the shape of the emitter and the high-pressure head (200 kPa). HF-DLF dilution at 10%, 25%, and 50% consisted in +1.9%, +3.5, and -4.9% amount of liquid released compared to the control. Fluid temperature during irrigation (from 9:00 to 17:00) did not explain the difference in the released amounts of liquid. In 10% HF-DLF % and 25% HF-DLF, a pH difference of + 0.321 ± 0.014 pH units compared to the control was found, and such difference was constant for both dilutions and at increasing the time. In contrast, 50% HF-DLF increased pH by around a half point and such difference increased with time. Similar differences among treatments were found for the total solids in the liquid. These results indicate that 50% HF-DLF was accumulating materials in the serpentine. These results suggest that a low diluted HF-DLF could directly be injected in irrigation systems with few drawbacks for the irrigation system and contribute to water conservation since such wastewater are available from the late spring to the early fall, when water requirements are high

Inundation mapping – a study based on December 2004 Tsunami Hazard along Chennai coast, Southeast India

Tsunami impact study has been undertaken along Chennai coast starting from Pulicat to Kovalam. The study area Chennai coast is mainly devoted to prepare large scale action plan maps on tsunami inundation incorporating land use details derived from satellite data along with cadastral data using a GIS tool. Under tsunami inundation mapping along Chennai coast an integrated approach was adopted to prepare thematic maps on land use/land cover and coastal geomorphology using multispectral remote sensing data. The RTK dGPS instruments are used to collect elevation contour data at 0.5 m intervals for the Chennai coast. The GIS tool has been used to incorporate the elevation data, tsunami inundation markings obtained immediately after tsunami and thematic maps derived from remote sensing data. The outcome of this study provides an important clue on variations in tsunami inundation along Chennai coast, which is mainly controlled by local geomorphologic set-up, coastal zone elevation including coastal erosion protection measures and near shore bathymetry. This study highlights the information regarding most vulnerable areas of tsunami and also provides indication to demarcate suitable sites for rehabilitation

A narrow band neutrino beam with high precision flux measurements

The ENUBET facility is a proposed narrow band neutrino beam where lepton production is monitored at single particle level in the instrumented decay tunnel. This facility addresses simultaneously the two most important challenges for the next generation of cross section experiments: a superior control of the flux and flavor composition at source and a high level of tunability and precision in the selection of the energy of the outcoming neutrinos. We report here the latest results in the development and test of the instrumentation for the decay tunnel. Special emphasis is given to irradiation tests of the photo-sensors performed at INFN-LNL and CERN in 2017 and to the first application of polysiloxane-based scintillators in high energy physics.Comment: Poster presented at NuPhys2017 (London, 20-22 December 2017). 5 pages, 2 figure

The Meteorite Fall in Carancas, Lake Titicaca Region, Southern Peru: First Results

The meteorite fall that occurred on September 15, 2007, in the Carancas community is a rare case where it is possible to study both impact phenomenology and meteorite characteristics, including accurate time framework