Studies on Design, Synthesis and Biological Evaluation of Nitrogen Heterocycles

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A hot X-ray filament associated with A3017 galaxy cluster

Recent simulations and observations have shown large scale filaments in the cosmic web connecting nodes, with accreting materials (baryonic and dark matter) flowing through them. Current high sensitivity observations also show that the propagation of shocks through filaments can heat them up, and make filaments visible between two or more galaxy clusters or around massive clusters, based on optical and/or X-ray observations. We are reporting here the special case of the cluster A3017 associated with a hot filament. The temperature of the filament is 3.4$^{-0.77}_{+1.30}$ ~keV and its length is $\sim$ 1 Mpc. We have analysed its archival {\it Chandra} data and report various properties. We also analysed GMRT 235/610 MHz radio data. Radio observations have revealed symmetric two-sided lobes which fill cavities in the A3017 cluster core region, associated with central AGN. In the radio map, we also noticed a peculiar linear vertical radio structure in the X-ray filament region which might be associated with a cosmic filament shock. This radio structure could be a radio phoenix or old plasma where an old relativistic population is re-accelerated by shock propagation. Finally we put an upper limit on the radio luminosity of the filament region

MACS J0553.4−3342: a young merging galaxy cluster caught through the eyes of Chandra and HST

We present a detailed analysis of a young merging galaxy cluster \mac~(z=0.43), from {\it Chandra} X-ray and {\it Hubble Space Telescope} archival data. X-ray observations confirm that the X-ray emitting intra-cluster medium (ICM) in this system is among the hottest (average $T=12.1 \pm 0.6$ keV) and most luminous known. Comparison of X-ray and optical images confirm that this system hosts two merging subclusters SC1 and SC2, separated by a projected distance of about 650\,kpc. The subcluster SC2 is newly identified in this work, while another subcluster (SC0), previously thought to be part of this merging system, is shown to be possibly a foreground object. Apart from two subclusters, we find a tail-like structure in the X-ray image, extending to a projected distance of $\sim$1\,Mpc, along the north-east direction of the eastern subcluster (SC1). From a surface brightness analysis, we detect two sharp surface brightness edges at $\sim$40\arcsec ($\sim$320\,kpc) and $\sim$80\arcsec ($\sim$640\,kpc) to the east of SC1. The inner edge appears to be associated with a merger-driven cold front, while the outer one is likely to be due to a shock front, the presence of which, ahead of the cold front, makes this dynamically disturbed cluster interesting. Nearly all the early-type galaxies belonging to the two subclusters, including their BCGs, are part of a well-defined red sequence.Comment: 13 pages, 12 figures, 6 Tables, Accepted for publication in Monthly Notices of the Royal Astronomical Society Main Journa

The rationale and design of Insight into Nephrotic Syndrome: Investigating Genes, Health and Therapeutics (INSIGHT): a prospective cohort study of childhood nephrotic syndrome

Abstract Background Nephrotic syndrome is one of the most commonly diagnosed kidney diseases in childhood and its progressive forms can lead to chronic kidney disease (CKD) and/or end-stage renal disease (ESRD). There have been few longitudinal studies among a multi-ethnic cohort to determine potential risk factors influencing disease susceptibility, treatment response, and progression of nephrotic syndrome. Temporal relationships cannot be studied through cross-sectional study design. Understanding the interaction between various factors is critical to developing new strategies for treating children with kidney disease. We present the rationale and the study design of a longitudinal cohort study of children with nephrotic syndrome, the Insight into Nephrotic Syndrome: Investigating Genes, Health and Therapeutics (INSIGHT) study. The specific aims are to determine: 1) socio-demographic, environmental, and genetic factors that influence disease susceptibility; 2) rates of steroid treatment resistance and steroid treatment dependence, and identify factors that may modify treatment response; 3) clinical and genetic factors that influence disease susceptibility and progression to CKD and ESRD; and 4) the interaction between the course of illness and socio-demographic, environmental, and clinical risk factors. Methods/design INSIGHT is a disease-based observational longitudinal cohort study of children with nephrotic syndrome. At baseline, participants complete questionnaires and provide biological specimen samples (blood, urine, and toenail clippings). Follow-up questionnaires and repeat biological specimen collections are performed annually for up to five years. Discussion The proposed cohort will provide the structure to test various risk factors predicting or influencing disease susceptibility, treatment response, and progression to CKD among children with nephrotic syndrome. Trial registration ClinicalTrials.gov Identifier NCT01605266