Innocampus Explora: Nuevas formas de comunicar ciencia

[EN] Innocampus Explora aims to show the students of the Burjassot-Paterna campus of the Universitat de València how the different scientific degrees are interrelated. To do this we propose activities in which students and teachers work together to cover the interdisciplinary nature of science, both in everyday and professional issues. Throughout this course the activities developed relate to new ways to communicate science. With the development of this project we contribute to a transversal quality education for all the participating students.[ES] Innocampus Explora tiene por objetivo mostrar a los estudiantes del campus de Burjassot-Paterna de la Universitat de València cómo los diferentes grados científicos están interrelacionados. Para ello proponemos actividades en las que estudiantes y profesores trabajen conjuntamente para abarcar la interdisciplinariedad de la ciencia, tanto en temas cotidianos como profesionales. A lo largo de este curso las actividades desarrolladas se relacionan con las nuevas formas de comunicar ciencia. Con el desarrollo de este proyecto contribuimos a una formación transversal de calidad para todos los estudiantes participantes.Moros Gregorio, J.; Rodrigo Martínez, P.; Torres Piedras, C.; Montoya Martínez, L.; Peña Peña, J.; Pla Díaz, M.; Galarza Jiménez, P.... (2019). Innocampus Explora: Nuevas formas de comunicar ciencia. En IN-RED 2019. V Congreso de Innovación Educativa y Docencia en Red. Editorial Universitat Politècnica de València. 814-823. https://doi.org/10.4995/INRED2019.2019.10449OCS81482

Quorum sensing network in clinical strains of A. baumannii : AidA is a new quorum quenching enzyme

Acinetobacter baumannii is an important pathogen that causes nosocomial infections generally associated with high mortality and morbidity in Intensive Care Units (ICUs). Currently, little is known about the Quorum Sensing (QS)/Quorum Quenching (QQ) systems of this pathogen. We analyzed these mechanisms in seven clinical isolates of A. baumannii. Microarray analysis of one of these clinical isolates, Ab1 (A. baumannii ST-2-clon-2010), previously cultured in the presence of 3-oxo-C12-HSL (a QS signalling molecule) revealed a putative QQ enzyme (α/β hydrolase gene, AidA). This QQ enzyme was present in all nonmotile clinical isolates (67% of which were isolated from the respiratory tract) cultured in nutrient depleted LB medium. Interestingly, this gene was not located in the genome of the only motile clinical strain growing in this medium (A. baumannii strain Ab421-GEIH-2010 [Ab7], isolated from a blood sample). The AidA protein expressed in E. coli showed QQ activity. Finally, we observed downregulation of the AidA protein (QQ system attenuation) in the presence of HO (ROS stress). In conclusion, most of the A. baumannii clinical strains were not surface motile (84%) and were of respiratory origin (67%). Only the pilT gene was involved in surface motility and related to the QS system. Finally, a new QQ enzyme (α/β hydrolase gene, AidA protein) was detected in these strains