Spontaneous regression of metastatic renal cell carcinoma: case report

Spontaneous regression of metastatic renal cell carcinoma is rarely observed. A case of suspected spontaneous regression of pulmonary metastases following nephrectomy for histologically proven renal cell carcinoma without systemic treatment is presented along with a brief review of the literature

Does the Value-at-Risk legal framework lead to inaccurate and procyclical risk estimations? Empirical Evidence from the EU countries.

This analysis tests whether the quantitative requirements of the law (Basel and Committee of European Securities Regulators) regarding the Value at Risk (VaR) framework may lead to inaccurate and procyclical VaR estimations. We apply two of the most popular VaR models, the Historical (HVaR) and the Exponential Weighted Moving Average (EWMA VaR) models, to a wide sample of 13 European Indices during the period 2002-2019. The empirical evidence confirms our assumptions that the legal framework in many cases leads to inaccurate and procyclical VaR estimations. Moreover, we show that the limitation on the required data inputs does not really contribute to a more stable financial environment. Further, we show that the current framework does not examine the procyclicality issue. The evidence in this study shows that the current legal framework needs some reforms: (a) the guideline on the minimum number of data inputs for the VaR estimations should be removed, taking provided that the accuracy of the applied VaR model is often evaluated, and (b) the current backtesting procedure does not examine whether VaR estimations are representative of the financial conditions. An additional backtesting procedure at a lower that the 99% confidence level could resolve this issue

Small Bowel Obstruction Following Computed Tomography and Magnetic Resonance Enterography Using Psyllium Seed Husk As an Oral Contrast Agent

The authors report a case series describing four patients who developed small bowel obstruction following the use of psyllium seed husk as an oral contrast agent for computed tomography or magnetic resonance enterography. Radiologists who oversee computed tomography and magnetic resonance enterography should be aware of this potential complication when using psyllium seed husk and other bulking agents, particularly when imaging patients with known or suspected small bowel strictures or active inflammation

Improvement of ischemic cholangiopathy in three patients with hereditary hemorrhagic telangiectasia following treatment with bevacizumab

AbstractThe ischemic biliary phenotype of hereditary hemorrhagic telangiectasia (HHT) is rare but distinct, with progressive biliary tree ischemia usually resulting in an irreversible secondary sclerosing cholangiopathy. When clinically severe, liver transplant is often indicated. We report three patients with marked HHT associated biliary disease, in whom prolonged anti-vascular endothelial growth factor therapy (bevacizumab) notably reversed imaging evidence of biliary disease and clinically obviated need for liver transplantation during the first year of follow-up