A wide field X-ray telescope for astronomical survey purposes: from theory to practice

X-ray mirrors are usually built in the Wolter I (paraboloid-hyperboloid) configuration. This design exhibits no spherical aberration on-axis but suffers from field curvature, coma and astigmatism, therefore the angular resolution degrades rapidly with increasing off-axis angles. Different mirror designs exist in which the primary and secondary mirror profiles are expanded as a power series in order to increase the angular resolution at large off-axis positions, at the expanses of the on-axis performances. Here we present the design and global trade off study of an X-ray mirror systems based on polynomial optics in view of the Wide Field X-ray Telescope (WFXT) mission. WFXT aims at performing an extended cosmological survey in the soft X-ray band with unprecedented flux sensitivity. To achieve these goals the angular resolution required for the mission is very demanding ~5 arcsec mean resolution across a 1-deg field of view. In addition an effective area of 5-9000 cm^2 at 1 keV is needed.Comment: Accepted for publication in the MNRAS (11pages, 3 table, 13 figures

Halpha rotation curves: the soft core question

We present high resolution Halpha rotation curves of 4 late-type dwarf galaxies and 2 low surface brightness galaxies (LSB) for which accurate HI rotation curves are available from the literature. Observations are carried out at Telescopio Nazionale Galileo (TNG). For LSB F583-1 an innovative dispersing element was used, the Volume Phase Holographic (VPH) with a dispersion of about 0.35 A/pxl. We find good agreement between the Halpha data and the HI observations and conclude that the HI data for these galaxies suffer very little from beam smearing. We show that the optical rotation curves of these dark matter dominated galaxies are best fitted by the Burkert profile. In the centers of galaxies, where the N-body simulations predict cuspy cores and fast rising rotation curves, our data seem to be in better agreement with the presence of soft cores.Comment: Accepted for Publication in ApJ with minor changes require

Ray-tracing of displaced SPO mirror modules

The report includes a description of the method used for simulating the effects of SPO MM rotations in the Athena geometry. The main results are also included

Nanopatterned acellular valve conduits drive the commitment of blood-derived multipotent cells

Considerable progress has been made in recent years toward elucidating the correlation among nanoscale topography, mechanical properties, and biological behavior of cardiac valve substitutes. Porcine TriCol scaffolds are promising valve tissue engineering matrices with demonstrated self-repopulation potentiality. In order to define an in vitro model for investigating the influence of extracellular matrix signaling on the growth pattern of colonizing blood-derived cells, we cultured circulating multipotent cells (CMC) on acellular aortic (AVL) and pulmonary (PVL) valve conduits prepared with TriCol method and under no-flow condition. Isolated by our group from Vietnamese pigs before heart valve prosthetic implantation, porcine CMC revealed high proliferative abilities, three-lineage differentiative potential, and distinct hematopoietic/endothelial and mesenchymal properties. Their interaction with valve extracellular matrix nanostructures boosted differential messenger RNA expression pattern and morphologic features on AVL compared to PVL, while promoting on both matrices the commitment to valvular and endothelial cell-like phenotypes. Based on their origin from peripheral blood, porcine CMC are hypothesized in vivo to exert a pivotal role to homeostatically replenish valve cells and contribute to hetero- or allograft colonization. Furthermore, due to their high responsivity to extracellular matrix nanostructure signaling, porcine CMC could be useful for a preliminary evaluation of heart valve prosthetic functionality

Design, Manufacturing, and Commissioning of BIRCAM (Bootes InfraRed CAMera)

This paper covers the various aspect of design, manufacturing and commissioning of the infrared camera BIRCAM, installed at BOOTES-IR, the 60 cm robotic infrared telescope at Sierra Nevada Observatory (OSN, Granada, Spain). We describe how we achieved a quality astronomical image, moving from the scientific requirements

Endothelial cells from human cerebral aneurysm and arteriovenous malformation release ET-1 in response to vessel rupture

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Design, Manufacturing, and Commissioning of BIRCAM (Bootes InfraRed CAMera)

This paper covers the various aspect of design, manufacturing and commissioning of the infrared camera BIRCAM, installed at BOOTES-IR, the 60 cm robotic infrared telescope at Sierra Nevada Observatory (OSN, Granada, Spain). We describe how we achieved a quality astronomical image, moving from the scientific requirements

Umbilical cord mesenchymal stem cells modulate dextran sulphate sodium induced acute colitis in immunodeficient mice.

Inflammatory bowel diseases (IBD) are complex multi-factorial diseases with increasing incidence worldwide but their treatment is far from satisfactory. Unconventional strategies have consequently been investigated, proposing the use of stem cells as an effective alternative approach to IBD. In the present study we examined the protective potential of exogenously administered human umbilical cord derived mesenchymal stem cells (UCMSCs) against Dextran Sulphate Sodium (DSS) induced acute colitis in immunodeficient NOD.CB17-Prkdc scid/J mice with particular attention to endoplasmic reticulum (ER) stress. METHODS: UCMSCs were injected in NOD.CB17-Prkdc scid/J via the tail vein at day 1 and 4 after DSS administration. To verify attenuation of DSS induced damage by UCMSCs, Disease Activity Index (DAI) and body weight changes was monitored daily. Moreover, colon length, histological changes, myeloperoxidase and catalase activities, metalloproteinase (MMP) 2 and 9 expression and endoplasmic reticulum (ER) stress related proteins were evaluated on day 7. RESULTS: UCMSCs administration to immunodeficient NOD.CB17-Prkdc scid/J mice after DSS damage significantly reduced DAI (1.45\u2009\ub1\u20090.16 vs 2.08\u2009\ub1\u20090.18, p\u20093-fold), which were significantly reduced in mice receiving UCMSCs. Moreover, positive modulation in ER stress related proteins was observed after UCMSC administration. CONCLUSIONS: Our results demonstrated that UCMSCs are able to prevent DSS-induced colitis in immunodeficient mice. Using these mice we demonstrated that our UCMSCs have a direct preventive effect other than the T-cell immunomodulatory properties which are already known. Moreover we demonstrated a key function of MMPs and ER stress in the establishment of colitis suggesting them to be potential therapeutic targets in IBD treatment