Median (interquartile range) score values in patients with and without DAPT prolongation.

<p>The atherothrombotic score derived from the TRA 2°P population indicates the risk of major adverse cardiac events, the PRECISE-DAPT score the risk of bleeding. DAPT = Dual antiplatelet therapy.</p

Logistic regression analysis for independent predictors of DAPT prolongation beyond one year after ACS.

<p>DAPT = Dual antiplatelet therapy; Cr Cl = Creatinine clearance; DES = Drug-eluting stent; MACE = Major adverse cardiovascular events; PAD = Peripheral artery disease; PCI = Percutaneous coronary intervention; STEMI = ST-segment elevation myocardial infarction; TIA = Transient ischemic attack.</p

Cardiovascular drugs^† prescribed at the end of the visit or at hospital discharge in patients with and without angina.

<p>^†Drugs not reported have been used in less than 5% of cases. ACE-I: angiotensin converting enzyme inhibitors; ARB: angiotensin receptor blockers; ASA: acetylsalicylic acid; DAPT: dual antiplatelet therapy; MRA: mineralocorticoid receptor antagonist; OAT: oral anticoagulation therapy.</p

Baseline clinical, hemodynamic and laboratory variables of patients without and with angina.

<p>Baseline clinical, hemodynamic and laboratory variables of patients without and with angina.</p

Timing (days) from diagnostic procedures to enrollment, median (IQR).

<p>Timing (days) from diagnostic procedures to enrollment, median (IQR).</p

Characteristics, treatment and quality of life of stable coronary artery disease patients with or without angina: Insights from the START study - Fig 3

<p>Domain of movement ability (panel A), body care (panel B), daily activities (panel C), pain/worry (panel D), and anxiety/depression (panel E) of the EQ 5D-5L questionnaire in patients with and without angina.</p

Biomarkers of acute cardiovascular and pulmonary diseases

Acute cardiothoracic and respiratory diseases frequently remain a challenge to diagnose and differentiate in the emergency setting. The main diseases that manifest with chest pain include ischaemic heart disease, myocarditis, acute pericarditis, aortic dissection/rupture and pulmonary embolism (PE). Diseases that primarily present with dyspnoea include heart failure (HF), acute respiratory distress syndrome (ARDS), pneumonia, asthma exacerbations and chronic obstructive pulmonary disease. Pre-test probabilities of clinical findings play a vital part in diagnostic decisions, and the use of a Bayesian approach to these greatly improves the ability to stratify patients more accurately. However, blood tests (biomarkers) are increasingly used to assist in rapid decision-making in the emergency setting in combination with imaging methods such as chest radiograph, ultrasound and increasingly computed tomography, as well as physiological tests such as the electrocardiogram in addition to physical examination. Specific tests for ischaemic heart disease and myocarditis (cardiac troponins), HF (B-type natriuretic peptide (BNP) and N-terminal proBNP (NT-proBNP)), aortic dissection (smooth muscle markers) and PE (D-dimer) have been developed. Surfactant protein-D and interleukin-8 have been developed for ARDS. Additionally, circulating microRNAs have emerged as promising biomarker candidates in cardiovascular disease. With this increasing array of biochemical markers to aid in the diagnosis of chest diseases presenting with chest pain and dyspnoea, we herein review the clinical usefulness of these markers, in particular in differentiating cardiac from pulmonary diseases. A symptom-oriented assessment as necessary for use in the critical setting is described in addition to discussion of individual biomarkers

Data_Sheet_1_The impact of UEFA Euro 2020 football championship on Takotsubo Syndrome: Results of a multicenter national registry.PDF

ObjectivesThe UEFA 2020 European Football Championship held in multiple cities across Europe from June 11 to July 11, 2021, was won by Italy, providing an opportunity to examine the relationship between emotional stress and the incidence of acute cardiovascular events (ACE).Methods and resultsCardiovascular hospitalizations in the Cardiac Care Units of 49 hospital networks in Italy were assessed by emergency physicians during the UEFA Euro 2020 Football Championship. We compared the events that occurred during matches involving Italy with events that occurred during the remaining days of the championship as the control period. ACE was assessed in 1,235 patients. ACE during the UEFA Euro 2020 Football Championship semifinal and final, the most stressful matches ended with penalties and victory of the Italian team, were assessed. A significant increase in the incidence of Takotsubo Syndrome (TTS) by a factor of 11.41 (1.6–495.1, P ConclusionsThe data of this national registry demonstrated an association between the semifinal and final of UEFA Euro 2020 and TTS suggesting that it can be triggered by also positive emotions such as the victory in the European Football Championship finals.</p